Search Results - "Muzi, Paola"

Tau oligomers accumulation sensitizes prostate cancer cells to docetaxel treatment by Martellucci, Stefano, Clementi, Letizia, Sabetta, Samantha, Muzi, Paola, Mattei, Vincenzo, Bologna, Mauro, Angelucci, Adriano

“…Purpose Human tau is a highly dynamic, multifunctional protein expressed in different isoforms and conformers, known to modulate microtubule turnover. Tau…”
Get full text

CXCR4 pharmacogical inhibition reduces bone and soft tissue metastatic burden by affecting tumor growth and tumorigenic potential in prostate cancer preclinical models by Gravina, Giovanni Luca, Mancini, Andrea, Muzi, Paola, Ventura, Luca, Biordi, Leda, Ricevuto, Enrico, Pompili, Simona, Mattei, Claudia, Di Cesare, Ernesto, Jannini, Emmanuele A., Festuccia, Claudio

“…BACKGROUND The majority of prostate cancer (Pca) patient morbidity can be attributed to bone metastatic events, which poses a significant clinical obstacle…”
Get full text

Azacitidine improves antitumor effects of docetaxel and cisplatin in aggressive prostate cancer models by Festuccia, Claudio, Gravina, Giovanni Luca, D'Alessandro, Anna Maria, Muzi, Paola, Millimaggi, Danilo, Dolo, Vincenza, Ricevuto, Enrico, Vicentini, Carlo, Bologna, Mauro

“…One of the major obstacles in the treatment of hormone-refractory prostate cancer (HRPC) is the development of chemoresistant tumors. The aim of this study is…”
Get full text

Trifluoroibuprofen inhibits α-methylacyl coenzyme A racemase (AMACR/P504S), reduces cancer cell proliferation and inhibits in vivo tumor growth in aggressive prostate cancer models by Festuccia, Claudio, Gravina, Giovanni Luca, Mancini, Andrea, Muzi, Paola, Cesare, Ernesto Di, Kirk, Ralph, Smith, Matthew, Hughes, Shaun, Gibson, Robert, Lian, Lu-Yun, Ricevuto, Enrico, Carnell, Andrew J

“…α-Methylacyl-CoA racemase (AMACR) participates in the oxidation of branched chain fatty acids and is highly expressed in prostate cancer (PCa). The aims of…”
Get more information

Suppression of EGF-R signaling reduces the incidence of prostate cancer metastasis in nude mice by Angelucci, Adriano, Gravina, Giovanni Luca, Rucci, Nadia, Millimaggi, Danilo, Festuccia, Claudio, Muzi, Paola, Teti, Anna, Vicentini, Carlo, Bologna, Mauro

“…The activation of epidermal growth factor receptor (EGF-R) plays a key role in the promotion of proliferation and invasion in prostatic carcinoma (PCa)…”
Get full text

Epidermal growth factor modulates prostate cancer cell invasiveness regulating urokinase-type plasminogen activator activity. EGF-receptor inhibition may prevent tumor cell dissemination by Festuccia, Claudio, Angelucci, Adriano, Gravina, Giovanni Luca, Biordi, Leda, Millimaggi, Danilo, Muzi, Paola, Vicentini, Carlo, Bologna, Mauro

“…Urokinase-type plasminogen activator receptor (uPAR) and Epidermal Growth Factor Receptor (EGFR) are ubiquitous receptors involved in the control of a variety…”
Get more information

Bicalutamide increases phospho-Akt levels through Her2 in patients with prostate cancer by Festuccia, Claudio, Gravina, Giovanni Luca, Muzi, Paola, Pomante, Roberto, Ventura, Luca, Vessella, Robert L, Vicentini, Carlo, Bologna, Mauro

“…Bicalutamide monotherapy is emerging as an alternative in the treatment of locally advanced prostate cancer. However, a significant number of these patients…”
Get full text

Arachidonic acid modulates the crosstalk between prostate carcinoma and bone stromal cells by Angelucci, Adriano, Garofalo, Stefania, Speca, Silvia, Bovadilla, Antonella, Gravina, Giovanni Luca, Muzi, Paola, Vicentini, Carlo, Bologna, Mauro

“…Diets high in n-6 fatty acids are associated with an increased risk of bone metastasis from prostate carces (PCa). The molecular mechanism underlying this…”
Get full text

Role of nitric oxide in the impairment of circular muscle contractility of distended, uninflamed mid-colon in TNBS-induced acute distal colitis in rats by Onori, Luciano

“…AIM： To evaluate the role of nitric oxide （NO） in the motor disorders of the dilated uninflamed mid-colon （DUMC） from trinitrobenzene sulfonic acid…”
Get full text

TLR4 and TLR9 Expression in Different Phenotypes of Rhinitis by Lauriello, Maria, Micera, Alessandra, Muzi, Paola, Di Rienzo Businco, Lino, Bonini, Sergio

“…Background. Toll-like receptors (TLRs) represent a family of evolutionarily conserved proteins, that represent a fundamental link between innate and adaptive…”
Get full text

Psychoneuroendocrinoimmunology-based meditation (PNEIMED) training reduces salivary cortisol under basal and stressful conditions in healthy university students: Results of a randomized controlled study by Bottaccioli, Anna Giulia, Bottaccioli, Francesco, Carosella, Antonia, Cofini, Vincenza, Muzi, Paola, Bologna, Mauro

“…Meditation represents an effective and safe practice to lower distress and promote well-being. PsychoNeuroEndocrinoImmunology-based Meditation (PNEIMED) is a…”
Get full text

Increased levels of DNA methyltransferases are associated with the tumorigenic capacity of prostate cancer cells by GRAVINA, GIOVANNI LUCA, RANIERI, GUIDO, MUZI, PAOLA, MARAMPON, FRANCESCO, MANCINI, ANDREA, DI PASQUALE, BORIS, DI CLEMENTE, LUIGI, DOLO, VINCENZA, D'ALESSANDRO, ANNA MARIA, FESTUCCIA, CLAUDIO

“…DNA methylation might be the earliest somatic genome changes in prostate cancer that also play an important role in the process of tumor invasion, growth and…”
Get full text

PXD101 potentiates hormonal therapy and prevents the onset of castration-resistant phenotype modulating androgen receptor, HSP90, and CRM1 in preclinical models of prostate cancer by Gravina, Giovanni Luca, Marampon, Francesco, Muzi, Paola, Mancini, Andrea, Piccolella, Margherita, Negri-Cesi, Paola, Motta, Marcella, Lenzi, Andrea, Di Cesare, Ernesto, Tombolini, Vincenzo, Jannini, Emmanuele A, Festuccia, Claudio

“…Aberrant activation or ‘reactivation’ of androgen receptor (AR) during androgen ablation therapy shows a potential cause for the development of…”
Get full text

Pyrazolo[3,4- d]pyrimidines c-Src inhibitors reduce epidermal growth factor-induced migration in prostate cancer cells by Angelucci, Adriano, Schenone, Silvia, Gravina, Giovanni Luca, Muzi, Paola, Festuccia, Claudio, Vicentini, Carlo, Botta, Maurizio, Bologna, Mauro

“…During its biological progression, prostate cancer frequently develops dependence on growth factor receptors and their downstream signalling messengers,…”
Get full text

CXCR4 pharmacogical inhibition reduces bone and soft tissue metastatic burden by affecting tumor growth and tumorigenic potential in prostate cancer preclinical models: CXCR4 Inhibition Has Anti-Tumor and Anti-Metastatic Effects in Prostate Cancer Models by Gravina, Giovanni Luca, Mancini, Andrea, Muzi, Paola, Ventura, Luca, Biordi, Leda, Ricevuto, Enrico, Pompili, Simona, Mattei, Claudia, Di Cesare, Ernesto, Jannini, Emmanuele A., Festuccia, Claudio

Get full text

Tyrosine kinase inhibitor CEP-701 blocks the NTRK1/NGF receptor and limits the invasive capability of prostate cancer cells in vitro by Festuccia, Claudio, Muzi, Paola, Gravina, Giovanni Luca, Millimaggi, Danilo, Speca, Silvia, Dolo, Vincenza, Ricevuto, Enrico, Vicentini, Carlo, Bologna, Mauro

“…In the prostate, cellular growth and differentiation are finely regulated by a complex interaction between stromal and epithelial cells under the control of…”
Get full text

Akt down-modulation induces apoptosis of human prostate cancer cells and synergizes with EGFR tyrosine kinase inhibitors by Festuccia, Claudio, Gravina, Giovanni Luca, Muzi, Paola, Millimaggi, Danilo, Dolo, Vincenza, Vicentini, Carlo, Bologna, Mauro

“…BACKGROUND PTEN is a well‐characterized tumor suppressor that negatively regulates cell growth and survival through the modulation of PI3K/Akt pathway. METHODS…”
Get full text

Abstract 3440: CRM1-Selective Inhibitors of Nuclear Export (SINE) reduce the incidence of tumor spreading and improve overall survival in preclinical models of prostate cancer by Gravina, Giovanni Luca, Tortoreto, Monica, Mancini, Andrea, Muzi, Paola, Ventura, Luca, D'ascenzo, Sandra, Addis, Alessandro, Landesman, Yosef, McCauley, Dilara, Dolo, Vincenza, Kauffman, Michael, Shacham, Sharon, Zaffaroni, Nadia, Festuccia, Claudio

“…Abstract Background: CRM1 (XPO1) is the exclusive exportin mediating transport of most tumor suppressor proteins (TSPs) including p53, pRb, FOXO, APC and p21…”
Get full text

Effects of dutasteride on prostate carcinoma primary cultures: a comparative study with finasteride and MK386 by Festuccia, Claudio, Gravina, Giovanni Luca, Muzi, Paola, Pomante, Roberto, Angelucci, Adriano, Vicentini, Carlo, Bologna, Mauro

“…The profound decrease in serum dihydrotestosterone observed with the dual 5alpha-reductase inhibitor dutasteride makes it an attractive agent for prostate…”
Get more information

Her2 crosstalks with TrkA in a subset of prostate cancer cells: Rationale for a guided dual treatment by Festuccia, Claudio, Gravina, Giovanni Luca, Muzi, Paola, Millimaggi, Danilo, Dolo, Vincenza, Vicentini, Carlo, Ficorella, Corrado, Ricevuto, Enrico, Bologna, Mauro

“…BACKGROUND To date, no effective therapeutic treatment prevents prostate cancer (PCa) progression to more advanced and invasive disease forms. It has been…”
Get full text