Search Results - "Mutwiri, George"

TLR9 agonists: Immune mechanisms and therapeutic potential in domestic animals by Mutwiri, George

“…Toll like receptors (TLRs) are transmembrane glycoproteins that recognize conserved microbial molecules. Engagement of TLRs activates innate and adaptive…”
Get full text

Chicken TLR21 acts as a functional homologue to mammalian TLR9 in the recognition of CpG oligodeoxynucleotides by Brownlie, Robert, Zhu, Jianzhong, Allan, Brenda, Mutwiri, George K., Babiuk, Lorne A., Potter, Andrew, Griebel, Philip

“…Similar to mammalian species, chickens show marked immunological responses to CpG oligodeoxynucleotides (ODNs) both in vivo and in vitro. In mammals, the…”
Get full text

Factors Associated with COVID-19 Vaccine Hesitancy among Visible Minority Groups from a Global Context: A Scoping Review by Ochieng, Candy, Anand, Sabrita, Mutwiri, George, Szafron, Michael, Alphonsus, Khrisha

“…Vaccine hesitancy is one of the top ten greatest threats to global health. During the COVID-19 era, vaccine hesitancy poses substantial risks, especially in…”
Get full text

Identification of RNA Sequence Motifs Stimulating Sequence-Specific TLR8-Dependent Immune Responses by Forsbach, Alexandra, Nemorin, Jean-Guy, Montino, Carmen, Muller, Christian, Samulowitz, Ulrike, Vicari, Alain P, Jurk, Marion, Mutwiri, George K, Krieg, Arthur M, Lipford, Grayson B, Vollmer, Jorg

“…The TLRs 7, 8, and 9 stimulate innate immune responses upon recognizing pathogen nucleic acids. U-rich RNA sequences were recently discovered that stimulate…”
Get full text

Kinome Analysis to Define Mechanisms of Adjuvant Action: PCEP Induces Unique Signaling at the Injection Site and Lymph Nodes by Awate, Sunita, Scruten, Erin, Mutwiri, George, Napper, Scott

“…Understanding the mechanism of action of adjuvants through systems biology enables rationale criteria for their selection, optimization, and application. As…”
Get full text

Polyphosphazenes as Adjuvants for Animal Vaccines and Other Medical Applications by Chand, Dylan J, Magiri, Royford B, Wilson, Heather L, Mutwiri, George K

“…Polyphosphazenes are a class of experimental adjuvants that have shown great versatility as vaccine adjuvants in many animal species ranging from laboratory…”
Get full text

Poly[di(carboxylatophenoxy)phosphazene] Is a Potent Adjuvant for Intradermal Immunization by Andrianov, Alexander K., DeCollibus, Daniel P., Gillis, Helice A., Kha, Henry H., Marin, Alexander, Prausnitz, Mark R., Babiuk, Lorne A., Townsend, Hugh, Mutwiri, George

“…Intradermal immunization using microfabricated needles represents a potentially powerful technology, which can enhance immune responses and provide antigen…”
Get full text

Metabolic Activation of CsgD in the Regulation of Salmonella Biofilms by Sokaribo, Akosiererem S, Hansen, Elizabeth G, McCarthy, Madeline, Desin, Taseen S, Waldner, Landon L, MacKenzie, Keith D, Mutwiri, Jr, George, Herman, Nancy J, Herman, Dakoda J, Wang, Yejun, White, Aaron P

“…Among human food-borne pathogens, gastroenteritis-causing strains have the most real-world impact. Like all pathogens, their success relies on efficient…”
Get full text

Vaccine Formulation for Infectious Diseases and Adjuvant Mechanisms of Action by Wilson, Heather L., Haddadi, Azita, Mutwiri, George K.

“…The ultimate goal for vaccination is the generation of a safe and effective immune response that protects against diseases [...]…”
Get full text

Elastase-Dependent Live Attenuated Swine Influenza A Viruses Are Immunogenic and Confer Protection against Swine Influenza A Virus Infection in Pigs by Masic, Aleksandar, Booth, Jayaum S, Mutwiri, George K, Babiuk, Lorne A, Zhou, Yan

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

The Adjuvants Polyphosphazene (PCEP) and a Combination of Curdlan Plus Leptin Promote a Th17-Type Immune Response to an Intramuscular Vaccine in Mice by Chaffey, Alyssa, Hamonic, Glenn, Chand, Dylan, Mutwiri, George K., Wilson, Heather L.

“…Our aim was to determine whether polyphosphazene (PCEP), Curdlan (β-glucan, a dectin-1 agonist), and Leptin could act as adjuvants to promote a Th17-type…”
Get full text

Gender Differences Among Academic Radiation Oncology National Institutes of Health (NIH) Funding Recipients by Mutwiri, George, Kulanthaivelu, Roshini, Yuen, Joanna, Hussain, Mehwish, Jutras, Marc, Deville, Curtiland, Jagsi, Reshma, Khosa, Faisal

“…PurposeThe purpose of our study was to evaluate National Institutes of Health (NIH) funding recipients between 2016 and 2019 to determine if there was an…”
Get full text

Immunization with PCEP microparticles containing pertussis toxoid, CpG ODN and a synthetic innate defense regulator peptide induces protective immunity against pertussis by Garlapati, Srinivas, Eng, Nelson F, Kiros, Tadele G, Kindrachuk, Jason, Mutwiri, George K, Hancock, Robert E.W, Halperin, Scott A, Potter, Andrew A, Babiuk, Lorne A, Gerdts, Volker

“…Abstract We investigated the efficacy of a novel microparticle (MP) based vaccine formulation consisting of pertussis toxoid (PTd), polyphosphazene (PCEP), CpG…”
Get full text

Activation of adjuvant core response genes by the novel adjuvant PCEP by Awate, Sunita, Wilson, Heather L., Lai, Ken, Babiuk, Lorne A., Mutwiri, George

“…► PCEP is a strong modulator of “adjuvant core response genes” at the site of injection. ► PCEP activates early innate immune responses at the site of…”
Get full text

Strategies for enhancing the immunostimulatory effects of CpG oligodeoxynucleotides by Mutwiri, George K, Nichani, Anil K, Babiuk, Shawn, Babiuk, Lorne A

“…Synthetic oligodeoxynucleotides (ODN) containing CpG sequences are recognized as a “danger” signal by the immune system of mammals. As a consequence, CpG ODN…”
Get full text

Combination adjuvants: the next generation of adjuvants? by Mutwiri, George, Gerdts, Volker, van Drunen Littel-van den Hurk, Sylvia, Auray, Gael, Eng, Nelson, Garlapati, Srinivas, Babiuk, Lorne A, Potter, Andrew

“…Adjuvants are critical components of many vaccines. The majority of existing vaccines contain a single adjuvant. Owing to their inherent limitations, no single…”
Get more information

Zika Virus Causes Persistent Infection in Porcine Conceptuses and may Impair Health in Offspring by Darbellay, Joseph, Cox, Brian, Lai, Kenneth, Delgado-Ortega, Mario, Wheler, Colette, Wilson, Donald, Walker, Stewart, Starrak, Gregory, Hockley, Duncan, Huang, Yanyun, Mutwiri, George, Potter, Andrew, Gilmour, Matthew, Safronetz, David, Gerdts, Volker, Karniychuk, Uladzimir

“…Outcomes of Zika virus (ZIKV) infection in pregnant women vary from the birth of asymptomatic offspring to abnormal development and severe brain lesions in…”
Get full text

Immunogenicity and protective efficacy of an elastase-dependent live attenuated swine influenza virus vaccine administered intranasally in pigs by Masic, Aleksandar, Lu, Xinya, Li, Junwei, Mutwiri, George K, Babiuk, Lorne A, Brown, Earl G, Zhou, Yan

“…Abstract Influenza A virus is an important respiratory pathogen of swine that causes significant morbidity and economic impact on the swine industry…”
Get full text

Characterization of bovine Toll-like receptor 8: Ligand specificity, signaling essential sites and dimerization by Zhu, Jianzhong, Brownlie, Robert, Liu, Qiang, Babiuk, Lorne A., Potter, Andrew, Mutwiri, George K.

“…Toll-like receptors (TLRs) are a family of highly conserved germline-encoded pattern-recognition receptors (PRRs) and are essential for host immune response…”
Get full text

Porcine TLR8 and TLR7 are both activated by a selective TLR7 ligand, imiquimod by Zhu, Jianzhong, Lai, Ken, Brownile, Robert, Babiuk, Lorne A., Mutwiri, George K.

“…Toll-like receptors (TLRs) are a family of highly conserved germline-encoded pattern-recognition receptors (PRR), which are utilized by the innate immune…”
Get full text