Search Results - "Mutton, Laura N"

Combined MYC Activation and Pten Loss Are Sufficient to Create Genomic Instability and Lethal Metastatic Prostate Cancer by Hubbard, Gretchen K, Mutton, Laura N, Khalili, May, McMullin, Ryan P, Hicks, Jessica L, Bianchi-Frias, Daniella, Horn, Lucas A, Kulac, Ibrahim, Moubarek, Michael S, Nelson, Peter S, Yegnasubramanian, Srinivasan, De Marzo, Angelo M, Bieberich, Charles J

“…Genetic instability, a hallmark feature of human cancers including prostatic adenocarcinomas, is considered a driver of metastasis. Somatic copy number…”
Get full text

MYC overexpression induces prostatic intraepithelial neoplasia and loss of Nkx3.1 in mouse luminal epithelial cells by Iwata, Tsuyoshi, Schultz, Denise, Hicks, Jessica, Hubbard, Gretchen K, Mutton, Laura N, Lotan, Tamara L, Bethel, Carlise, Lotz, Matthew T, Yegnasubramanian, Srinivasan, Nelson, William G, Dang, Chi V, Xu, MengMeng, Anele, Uzoma, Koh, Cheryl M, Bieberich, Charles J, De Marzo, Angelo M

“…Lo-MYC and Hi-MYC mice develop prostatic intraepithelial neoplasia (PIN) and prostatic adenocarcinoma as a result of MYC overexpression in the mouse prostate…”
Get full text

Proline-mediated Proteasomal Degradation of the Prostate-specific Tumor Suppressor NKX3.1 by Rao, Varsha, Guan, Bin, Mutton, Laura N., Bieberich, Charles J.

“…Reduced expression of the homeodomain transcription factor NKX3.1 is associated with prostate cancer initiation and progression. NKX3.1 turnover requires…”
Get full text

Ubiquitination by TOPORS Regulates the Prostate Tumor Suppressor NKX3.1 by Guan, Bin, Pungaliya, Pooja, Li, Xiang, Uquillas, Carlos, Mutton, Laura N., Rubin, Eric H., Bieberich, Charles J.

“…The NKX3.1 gene located at 8p21.2 encodes a homeodomain-containing transcription factor that acts as a haploinsufficient tumor suppressor in prostate cancer…”
Get full text

FOXA1-binding enhancer regulates Hoxb13 expression in the prostate gland by McMullin, Ryan P, Dobi, Albert, Mutton, Laura N, Orosz, András, Maheshwari, Shilpi, Shashikant, Cooduvalli S, Bieberich, Charles J

“…Hoxb13 is robustly transcribed in derivatives of posterior endoderm including the colon, rectum, and the prostate gland. Transcriptional activity in the…”
Get full text

Distinct regulatory elements mediate the dynamic expression pattern of Nkx3.1 by Chen, Hui, Mutton, Laura N., Prins, Gail S., Bieberich, Charles J.

“…Loss of Nkx3.1 function in mice results in defects in prostate development and epithelial hyperplasia, indicating that this gene plays important roles in both…”
Get full text

Loss of Nkx3.1 Expression in Bacterial Prostatitis: A Potential Link Between Inflammation and Neoplasia by KHALILI, May, MUTTON, Laura N, GUREL, Bora, HICKS, Jessica L, DE MARZO, Angelo M, BIEBERICH, Charles J

“…NKX3.1 is a homeodomain protein that functions as a dosage sensitive prostate-specific transcription factor. Diminished NKX3.1 expression is associated with…”
Get full text

Hoxb13 regulatory elements mediate transgene expression during prostate organogenesis and carcinogenesis by McMullin, Ryan P., Mutton, Laura N., Bieberich, Charles J.

“…The prostate requires androgens for development and homeostasis. Prostate cancer shares this dependence, however progression to androgen‐independence is common…”
Get full text

A Hoxb13-driven reverse tetracycline transactivator system for conditional gene expression in the prostate by Rao, Varsha, Heard, Jamie C., Ghaffari, Helya, Wali, Aminah, Mutton, Laura N., Bieberich, Charles J.

“…BACKGROUND Genetically engineered mouse models play important roles in analyses of prostate development and pathobiology. While constitutive genetic gain‐ and…”
Get full text

Loss of Nkx3.1 Expression in Bacterial Prostatitis by Khalili, May, Mutton, Laura N, Gurel, Bora, Hicks, Jessica L, De Marzo, Angelo M, Bieberich, Charles J

“…NKX3.1 is a homeodomain protein that functions as a dosage sensitive prostate-specific transcription factor. Diminished NKX3.1 expression is associated with…”
Get full text

Abstract 1086: MYC overexpression combined with Pten loss generates genomic instability and rapid metastasis in a new mouse model of lethal prostate adenocarcinoma by Hubbard, Gretchen K., Mutton, Laura N., Khalili, May, McMullin, Ryan P., Hicks, Jessica, Bianchi-Frias, Daniella, Nelson, Peter S., Yegnasubramanian, Srinivasan, De Marzo, Angelo M., Bieberich, Charles J.

“…Abstract There is a pressing need for animal models that recapitulate key pathological features of lethal human prostate adenocarcinoma. The availability of…”
Get full text

A Hoxbl3-Driven ReverseTetracyclineTransactivator System for Conditional Gene Expression in the Prostate by RAO, Varsha, HEARD, Jamie C, GHAFFARI, Helya, WALI, Aminah, MUTTON, Laura N, BIEBERICH, Charles J

Get full text