Search Results - "Mutter, G. L."

Diagnosis of premalignant endometrial disease by MUTTER, G. L

“…Modern molecular methods for precancer diagnosis have expanded the range of detectable disease to a preclinical level and provided material for…”
Get full text

Endometrial intraepithelial neoplasia is associated with polyps and frequently has metaplastic change by Carlson, J W, Mutter, G L

“…Aims:  Endometrial intraepithelial neoplasia (EIN) is a monoclonal precursor to endometrioid endometrial adenocarcinoma characterized by a geographic cluster…”
Get full text

Altered PTEN Expression as a Diagnostic Marker for the Earliest Endometrial Precancers by Mutter, George L., Lin, Ming-Chieh, Fitzgerald, Jeffrey T., Kum, Jennifer B., Baak, Jan P. A., Lees, Jacqueline A., Weng, Liang-Ping, Eng, Charis

“…Background: PTEN tumor suppressor gene mutations are the most frequent genetic lesions in endometrial adenocarcinomas of the endometrioid subtype. Testing the…”
Get full text

EIN and WHO94 by Baak, J P A, Mutter, G L

Get full text

Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors by WEBER, F, FUKINO, K, ENG, C, SAWADA, T, WILLIAMS, N, SWEET, K, BRENA, R. M, PLASS, C, CALDES, T, MUTTER, G. L, VILLALONA-CALERO, M. A

“…Organ-specific differences in epidermal growth factor receptor (EGFR) mutational spectra and frequencies were found in lung cancer and sporadic and…”
Get full text

Changes in endometrial PTEN expression throughout the human menstrual cycle by MUTTER, G. L, LIN, M.-C, FITZGERALD, J. T, KUM, J. B, ENG, C

“…Frequent mutation of the PTEN tumor suppressor gene in endometrial adenocarcinoma has led to the prediction that its product, a phosphatase that regulates the…”
Get full text

Immunohistochemical Evidence of Loss of PTEN Expression in Primary Ductal Adenocarcinomas of the Breast by Perren, Aurel, Weng, Liang-Ping, Boag, Alexander H., Ziebold, Ulricke, Thakore, Kosha, Dahia, Patricia L.M., Komminoth, Paul, Lees, Jacqueline A., Mulligan, Lois M., Mutter, George L., Eng, Charis

“…Germline mutations in PTEN, encoding a dual-specificity phosphatase on 10q23.3, cause Cowden syndrome (CS), which is characterized by a high risk of breast and…”
Get full text

hMLH1 Promoter Hypermethylation Is an Early Event in Human Endometrial Tumorigenesis by Esteller, Manel, Catasus, Lluis, Matias-Guiu, Xavier, Mutter, George L., Prat, Jaime, Baylin, Steve B., Herman, James G.

“…It has recently been suggested that silencing of the hMLH1 gene by promoter hypermethylation is the mechanism underlying the presence of the microsatellite…”
Get full text

Differential Nuclear and Cytoplasmic Expression of PTEN in Normal Thyroid Tissue, and Benign and Malignant Epithelial Thyroid Tumors by Gimm, Oliver, Perren, Aurel, Weng, Liang-Ping, Marsh, Debbie J., Yeh, Jen Jen, Ziebold, Ulrike, Gil, Elad, Hinze, Raoul, Delbridge, Leigh, Lees, Jacqueline A., Mutter, George L., Robinson, Bruce G., Komminoth, Paul, Dralle, Henning, Eng, Charis

“…Germline mutations in PTEN ( MMAC1/ TEP1) are found in patients with Cowden syndrome, a familial cancer syndrome which is characterized by a high risk of…”
Get full text

Endometrial precancer diagnosis by histopathology, clonal analysis, and computerized morphometry by Mutter, George L., Baak, Jan P. A., Crum, Christopher P., Richart, Ralph M., Ferenczy, Alex, Faquin, William C.

“…Management of endometrial precancers is compromised by longstanding debate over the natural history of endometrial hyperplasias and inconsistencies in their…”
Get full text

Somatic mitochondrial DNA (mtDNA) mutations in papillary thyroid carcinomas and differential mtDNA sequence variants in cases with thyroid tumours by JEN JEN YEH, LUNETTA, K. L, VAN ORSOUW, N. J, MOORE, F. D, MUTTER, G. L, VIJG, J, DAHIA, P. L. M, ENG, C

“…Somatic mutations in mtDNA have recently been identified in colorectal tumours. Studies of oncocytic tumours have led to hypotheses which propose that defects…”
Get full text

Linking gene expression patterns to therapeutic groups in breast cancer by MARTIN, K. J, KRITZMAN, B. M, PARDEE, A. B, SAGER, R, PRICE, L. M, KOH, B, KWAN, C.-P, XIAOHONG ZHANG, MACKAY, A, O'HARE, M. J, KAELIN, C. M, MUTTER, G. L

“…A major objective of current cancer research is to develop a detailed molecular characterization of tumor cells and tissues that is linked to clinical…”
Get full text

Disseminated peritoneal leiomyomatosis. Clonality analysis by X chromosome inactivation and cytogenetics of a clinically benign smooth muscle proliferation by Quade, BJ, McLachlin, CM, Soto-Wright, V, Zuckerman, J, Mutter, GL, Morton, CC

“…Disseminated peritoneal leiomyomatosis (DPL, leiomyomatosis peritonealis disseminata) is a rare condition in which multiple histologically benign smooth muscle…”
Get full text

A polymerase chain reaction assay for non-random X chromosome inactivation identifies monoclonal endometrial cancers and precancers by Mutter, GL, Chaponot, ML, Fletcher, JA

“…We hypothesize that endometrial carcinoma and their precursors share a monoclonal growth pattern and tested this thesis with archival paraffin-embedded tissues…”
Get full text

Expression of DAZ, an azoospermia factor candidate, in human spermatogonia by Menke, D B, Mutter, G L, Page, D C

Get full text

Allelotype mapping of unstable microsatellites establishes direct lineage continuity between endometrial precancers and cancer by MUTTER, G. L, BOYNTON, K. A, FAQUIN, W. C, RUIZ, R. E, JOVANOVIC, A. S

“…Progressive microsatellite changes in replication error positive (RER+) endometrium were used to reconstruct evolutionary stages of nonfamilial adenocarcinoma…”
Get full text

Monoclonal origin of vulvar intraepithelial neoplasia and some vulvar hyperplasias by Tate, JE, Mutter, GL, Boynton, KA, Crum, CP

“…Squamous neoplasms of the female genital tract, including vulvar intraepithelial neoplasia, presumably are derived from a single cell. This study addressed…”
Get full text

Patterns of allelic loss (LOH) in vulvar squamous carcinomas and adjacent noninvasive epithelia by Lin, MC, Mutter, GL, Trivijisilp, P, Boynton, KA, Sun, D, Crum, CP

“…The pathogenesis of carcinoma of the vulva is diverse and includes both human papilloma virus (HPV)-positive and HPV-negative pathways. The objective of this…”
Get full text

Distinct developmental patterns of c-mos protooncogene expression in female and male mouse germ cells by Mutter, G.L, Wolgemuth, D.J

“…The protooncogene c-mos is expressed in murine reproductive tissues, producing transcripts of 1.7 and 1.4 kilobases in testis and ovary, respectively. In situ…”
Get full text

Uteri of women with endometrial carcinoma contain a histopathological spectrum of monoclonal putative precancers, some with microsatellite instability by JOVANOVIC, A. S, BOYNTON, K. A, MUTTER, G. L

“…We have tested the hypothesis that endometrial precancers persist in uteri of patients with endometrial carcinoma and are monoclonal. Twenty-two hysterectomies…”
Get full text