Search Results - "Mutsuhiro Ikuma"

Conditional early approval for new drug applications in Japan: Current and emerging issues by Tanaka, Mototsugu, Miyazawa, Haruna, Terashima, Ryohei, Ikuma, Mutsuhiro

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Evolving Landscape of New Drug Approval in Japan and Lags from International Birth Dates: Retrospective Regulatory Analysis by Tanaka, Mototsugu, Idei, Mayumi, Sakaguchi, Hiroshi, Kato, Ryosuke, Sato, Daisuke, Sawanobori, Kenji, Kawarasaki, Shuichi, Hata, Toshiyuki, Yoshizaki, Asako, Nakamura, Miki, Ikuma, Mutsuhiro

“…The Pharmaceuticals and Medical Devices Agency (PMDA) has approved hundreds of new drugs in recent years. We retrospectively analyzed the new drugs approved in…”
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Achievements and challenges of the Sakigake designation system in Japan by Tanaka, Mototsugu, Idei, Mayumi, Sakaguchi, Hiroshi, Kato, Ryosuke, Sato, Daisuke, Sawanobori, Kenji, Kawarasaki, Shuichi, Hata, Toshiyuki, Yoshizaki, Asako, Nakamura, Miki, Ikuma, Mutsuhiro

“…The Sakigake designation system (Sakigake) has been launched to encourage the pioneered development of innovative new medical products for the effective…”
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Assessment of the impact of Japanese‐specific long‐term safety data on new drug approval by Uzu, Shinobu, Sekine, Shohko, Asano, Junichi, Ikuma, Mutsuhiro

“…Under the International Council for Harmonization (ICH)‐E1 guideline for drugs intended for chronic or repeated intermittent use in non‐life‐threatening…”
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Postmarket safety communications on drugs approved in Japan: A 25‐year analysis by Tanaka, Yusuke, Tanaka, Mototsugu, Miyazawa, Haruna, Terashima, Ryohei, Miyazawa, Makoto, Ikuma, Mutsuhiro, Tomita, Yoshihiko

“…Drug safety communications (DSCs) are essential tools for communicating important postmarket serious drug safety information to healthcare professionals and…”
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A deficiency of gastric interstitial cells of Cajal accompanied by decreased expression of neuronal nitric oxide synthase and substance P in patients with type 2 diabetes mellitus by Iwasaki, Hirohiko, Kajimura, Masayoshi, Osawa, Satoshi, Kanaoka, Shigeru, Furuta, Takahisa, Ikuma, Mutsuhiro, Hishida, Akira

“…Gastrointestinal motility is impaired in patients with diabetes mellitus (DM). Interstitial cells of Cajal (ICC) in the gastrointestinal tract play a central…”
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Fecal Cyclooxygenase 2 Plus Matrix Metalloproteinase 7 mRNA Assays as a Marker for Colorectal Cancer Screening by TAKAI, Tetsunari, KANAOKA, Shigeru, YOSHIDA, Ken-Ichi, HAMAYA, Yasushi, IKUMA, Mutsuhiro, MIURA, Naoyuki, SUGIMURA, Haruhiko, KAJIMURA, Masayoshi, HISHIDA, Akira

“…We previously reported that fecal cyclooxygenase 2 (COX-2) mRNA assay, detecting COX-2 mRNA in feces, is useful for identifying subjects with colorectal cancer…”
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Characteristics of non-erosive gastroesophageal reflux disease refractory to proton pump inhibitor therapy by Sugimoto, Mitsushige, Nishino, Masafumi, Kodaira, Chise, Yamade, Mihoko, Uotani, Takahiro, Ikuma, Mutsuhiro, Umemura, Kazuo, Furuta, Takahisa

“…AIM：To investigate whether potent acid inhibition is effective in non-erosive reflux disease （NERD） refractory to standard rabeprazole （RPZ） treatment…”
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Dual therapy with high doses of rabeprazole and amoxicillin versus triple therapy with rabeprazole, amoxicillin, and metronidazole as a rescue regimen for Helicobacter pylori infection after the standard triple therapy by SHIRAI, Naohito, SUGIMOTO, Mitsushige, KODAIRA, Chise, NISHINO, Masafumi, IKUMA, Mutsuhiro, KAJIMURA, Masayoshi, OHASHI, Kyoichi, ISHIZAKI, Takashi, HISHIDA, Akira, FURUTA, Takahisa

“…Development of safe and effective rescue regimens for eradication failure of Helicobacter pylori infection by standard regimens is an urgent task. We designed…”
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Relationship Between Low-Dose Aspirin-Induced Gastric Mucosal Injury and Intragastric pH in Healthy Volunteers by Nishino, Masafumi, Sugimoto, Mitsushige, Kodaira, Chise, Yamade, Mihoko, Shirai, Naohito, Ikuma, Mutsuhiro, Tanaka, Tatsuo, Sugimura, Haruhiko, Hishida, Akira, Furuta, Takahisa

“…Background and Aims Gastric acid plays an important role in the pathogenesis of gastric mucosal lesions. We investigated whether aspirin-induced gastric…”
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Impact of acid inhibition on esophageal mucosal injury induced by low-dose aspirin by Sugimoto, Mitsushige, Nishino, Masafumi, Kodaira, Chise, Yamade, Mihoko, Uotani, Takahiro, Ikuma, Mutsuhiro, Furuta, Takahisa

“…Aspirin enjoys widespread use as an antithrombotic drug, but such ubiquity also increases the risk of gastrointestinal mucosal injury. Recent studies have…”
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Statins directly suppress cytokine production in murine intraepithelial lymphocytes by Zhang, Jiong, Osawa, Satoshi, Takayanagi, Yasuhiro, Ikuma, Mutsuhiro, Yamada, Takanori, Sugimoto, Mitsushige, Furuta, Takahisa, Miyajima, Hiroaki, Sugimoto, Ken

“…► This study examined the direct effects of statins on cytokine production in IELs. ► Simvastatin and lovastatin suppressed Th1-cytokines and IL-4 produced by…”
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Normal Gating of CFTR Requires ATP Binding to Both Nucleotide-Binding Domains and Hydrolysis at the Second Nucleotide-Binding Domain by Berger, Allan L., Ikuma, Mutsuhiro, Welsh, Michael J.

“…ATP interacts with the two nucleotide-binding domains (NBDs) of CFTR to control gating. However, it is unclear whether gating involves ATP binding alone, or…”
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Influences of Chymase and Angiotensin I-Converting Enzyme Gene Polymorphisms on Gastric Cancer Risks in Japan by SUGIMOTO, Mitsushige, FURUTA, Takahisa, SHIRAI, Naohito, IKUMA, Mutsuhiro, SUGIMURA, Haruhiko, HISHIDA, Akira

“…Backgrounds and Aims: The renin-angiotensin system plays an important role in homeostasis. Angiotensin II, which is generated by chymase and angiotensin…”
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Influence of Different Proton Pump Inhibitors on Activity of Cytochrome P450 Assessed by [13C]-Aminopyrine Breath Test by Kodaira, Chise, Uchida, Shinya, Yamade, Mihoko, Nishino, Masafumi, Ikuma, Mutsuhiro, Namiki, Noriyuki, Sugimoto, Mitsushige, Watanabe, Hiroshi, Hishida, Akira, Furuta, Takahisa

“…Aminopyrine is metabolized by cytochrome P450 (CYP) in the liver. The investigators evaluated influences of different PPIs on CYP activity as assessed by the…”
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Cytokine responses of intraepithelial lymphocytes are regulated by histamine H₂ receptor by Takagaki, Kosuke, Osawa, Satoshi, Horio, Yoshiaki, Yamada, Takanori, Hamaya, Yasushi, Takayanagi, Yasuhiro, Furuta, Takahisa, Hishida, Akira, Ikuma, Mutsuhiro

“…Backgrounds Histamine participates in the immune regulation of several gastrointestinal diseases. However, the effect of histamine on intestinal…”
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Preventive Effects of Lansoprazole and Famotidine on Gastric Mucosal Injury Induced by Low-Dose Aspirin in Helicobacter pylori-Negative Healthy Volunteers by Nishino, Masafumi, Sugimoto, Mitsushige, Kodaira, Chise, Yamade, Mihoko, Uotani, Takahiro, Shirai, Naohito, Ikuma, Mutsuhiro, Tanaka, Tatsuo, Sugimura, Haruhiko, Hishida, Akira, Furuta, Takahisa

“…The preventive effects of lansoprazole and famotidine on low‐dose aspirin‐induced gastric mucosal injury in relation to gastric acidity were compared in…”
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Polymorphisms of matrix metalloproteinase-7 and chymase are associated with susceptibility to and progression of gastric cancer in Japan by Sugimoto, Mitsushige, Furuta, Takahisa, Kodaira, Chise, Nishino, Masafumi, Yamade, Mihoko, Ikuma, Mutsuhiro, Sugimura, Haruhiko, Hishida, Akira

“…Background Matrix metalloproteinases (MMPs) are a family of enzymes that degrade most macromolecules making up the extracellular matrix. MMPs are involved in…”
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Guggulsterone, a plant-derived inhibitor of NF-TB, suppresses CDX2 and COX-2 expression and reduces the viability of esophageal adenocarcinoma cells by Yamada, Takanori, Osawa, Satoshi, Ikuma, Mutsuhiro, Kajimura, Masayoshi, Sugimoto, Mitsushige, Furuta, Takahisa, Iwaizumi, Moriya, Sugimoto, Ken

“…Induction by bile acid of caudal type homeobox 2 (CDX2) and cyclooxygenase-2 (COX-2) expression via nuclear factor-κB (NF-κB) activation is a critical event in…”
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A case of small bowel adenocarcinoma in a patient with Crohn's disease detected by PET/CT and double-balloon enteroscopy by Kodaira, Chise, Osawa, Satoshi, Mochizuki, Chihiro, Sato, Yoshihiko, Nishino, Masafumi, Yamada, Takanori, Takayanagi, Yasuhiro, Takagaki, Kosuke, Sugimoto, Ken, Kanaoka, Shigeru, Furuta, Takahisa, Ikuma, Mutsuhiro

“…Small bowel adenocarcinoma (SBA) in patients with Crohn's disease (CD) is quite rare, difficult to diagnose without surgery, and has a poor prognosis. Here, we…”
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