Search Results - "Mutsuddi, Mousumi"

Regulation of Notch signaling by E3 ubiquitin ligases by Dutta, Debdeep, Sharma, Vartika, Mutsuddi, Mousumi, Mukherjee, Ashim

“…Notch signaling is an evolutionarily conserved pathway that is widely used for multiple cellular events during development. Activation of the Notch pathway…”
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E3 ubiquitin ligase Deltex facilitates the expansion of Wingless gradient and antagonizes Wingless signaling through a conserved mechanism of transcriptional effector Armadillo/β-catenin degradation by Sharma, Vartika, Sachan, Nalani, Sarkar, Bappi, Mutsuddi, Mousumi, Mukherjee, Ashim

“…The Wnt/Wg pathway controls myriads of biological phenomena throughout the development and adult life of all organisms across the phyla. Thus, an aberrant Wnt…”
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Spoonbill positively regulates JNK signalling mediated apoptosis in Drosophila melanogaster by Das, Rituparna, Pandey, Pranjali, Maurya, Bhawana, Pradhan, Priyadarshika, Sinha, Devanjan, Mukherjee, Ashim, Mutsuddi, Mousumi

“…A-kinase anchoring protein (AKAP) comprises a family of scaffold proteins, which decides the subcellular localisation of a combination of signalling molecules…”
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Maheshvara regulates JAK/STAT signaling by interacting and stabilizing hopscotch transcripts which leads to apoptosis in Drosophila melanogaster by Maurya, Bhawana, Surabhi, Satya, Das, Rituparna, Pandey, Pranjali, Mukherjee, Ashim, Mutsuddi, Mousumi

“…Maheshvara ( mahe ), an RNA helicase that is widely conserved across taxa, regulates Notch signaling and neuronal development in Drosophila . In order to…”
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The Drosophila importin-α3 is required for nuclear import of notch in vivo and it displays synergistic effects with notch receptor on cell proliferation by Sachan, Nalani, Mishra, Abhinava K, Mutsuddi, Mousumi, Mukherjee, Ashim

“…The Notch signaling pathway controls diverse cell-fate specification events throughout development. The versatility of this pathway to influence different…”
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In vivo effects of traditional Ayurvedic formulations in Drosophila melanogaster model relate with therapeutic applications by Dwivedi, Vibha, Anandan, E M, Mony, Rajesh S, Muraleedharan, T S, Valiathan, M S, Mutsuddi, Mousumi, Lakhotia, Subhash C

“…Ayurveda represents the traditional medicine system of India. Since mechanistic details of therapy in terms of current biology are not available in Ayurvedic…”
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Notch signals modulate lgl mediated tumorigenesis by the activation of JNK signaling by Paul, Maimuna Sali, Singh, Ankita, Dutta, Debdeep, Mutsuddi, Mousumi, Mukherjee, Ashim

“…Oncogenic potential of Notch signaling and its cooperation with other factors to affect proliferation are widely established. Notch exhibits a cooperative…”
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The RNA binding KH domain of Spoonbill depletes pathogenic non-coding spinocerebellar ataxia 8 transcripts and suppresses neurodegeneration in Drosophila by Tripathi, Bipin K., Surabhi, Satya, Bhaskar, Pradeep K., Mukherjee, Ashim, Mutsuddi, Mousumi

“…Spinocerebellar ataxia 8 (SCA8) pathogenesis is a resultant of gain-of-function machinery that primarily results at the RNA level. It has been reported that…”
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Pleiotropic Functions of the Chromodomain-Containing Protein Hat-trick During Oogenesis in Drosophila melanogaster by Singh, Ankita, Dutta, Debdeep, Paul, Maimuna Sali, Verma, Dipti, Mutsuddi, Mousumi, Mukherjee, Ashim

“…Chromatin-remodeling proteins have a profound role in the transcriptional regulation of gene expression during development. Here, we have shown that the…”
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MTHFR C677T predisposes to POAG but not to PACG in a North Indian population: a case control study by Gupta, Shashank, Bhaskar, Pradeep Kumar, Bhardwaj, Ritu, Chandra, Abhishek, Chaudhry, Vidya Nair, Chaudhry, Prashaant, Ali, Akhtar, Mukherjee, Ashim, Mutsuddi, Mousumi

“…Hyperhomocysteinemia induced by the C677T genetic variant in MTHFR (methylenetetrahydrofolate reductase) has been implicated in neuronal cell death of retinal…”
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Recent Updates on the Genetics of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia by Kirola, Laxmi, Mukherjee, Ashim, Mutsuddi, Mousumi

“…Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) primarily affect the motor and frontotemporal areas of the brain, respectively. These…”
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Molecular Genetics of Spinocerebellar Ataxia Type 8 (SCA8) by Mutsuddi, Mousumi, Rebay, Ilaria

“…Spinocerebellar Ataxias (SCAs) belong to a group of autosomal dominant, late-onset neurodegenerative disorders characterized by slowly progressive ataxia that…”
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Notch signalling: multifaceted role in development and disease by Sachan, Nalani, Sharma, Vartika, Mutsuddi, Mousumi, Mukherjee, Ashim

“…Notch pathway is an evolutionarily conserved signalling system that operates to influence an astonishing array of cell fate decisions in different…”
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Regulation of Notch signaling by non-muscle myosin II Zipper in Drosophila by Verma, Dipti, Singh, Ankita, Singh, Jyoti, Mutsuddi, Mousumi, Mukherjee, Ashim

“…The Notch pathway is an evolutionarily conserved signaling system that is intricately regulated at multiple levels and it influences different aspects of…”
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Deltex positively regulates Toll signaling in a JNK independent manner in Drosophila by Sharma, Vartika, Mutsuddi, Mousumi, Mukherjee, Ashim

“…Toll pathway is the center for the function of immune system in both Drosophila and mammals. Toll pathway in Drosophila gets activated upon binding of the…”
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Deltex cooperates with TRAF6 to promote apoptosis and cell migration through Eiger‐independent JNK activation in Drosophila by Sharma, Vartika, Mutsuddi, Mousumi, Mukherjee, Ashim

“…JNK signaling is a highly conserved signaling pathway that regulates a broad spectrum of cellular processes including cell proliferation, migration, and…”
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Deltex modulates Dpp morphogen gradient formation and affects Dpp signaling in Drosophila by Sharma, Vartika, Sarkar, Bappi, Mutsuddi, Mousumi, Mukherjee, Ashim

“…ABSTRACT Deltex (Dx) is a context-dependent regulator of Notch signaling that can act in a non-canonical fashion by facilitating the endocytosis of the Notch…”
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E3 ubiquitin ligase Deltex facilitates the expansion of Wingless gradient and antagonizes Wingless signaling through a conserved mechanism of transcriptional effector Armadillo/β-catenin degradation by Sharma, Vartika, Sachan, Nalani, Sarkar, Bappi, Mutsuddi, Mousumi, Mukherjee, Ashim

“…The Wnt/Wg pathway controls myriads of biological phenomena throughout the development and adult life of all organisms across the phyla. Thus, an aberrant Wnt…”
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Synergistic interaction of Deltex and Hrp48 leads to JNK activation by Dutta, Debdeep, Mutsuddi, Mousumi, Mukherjee, Ashim

“…The communication among the cells plays a seminal role in metazoan development by coordinating multiple cellular processes that, in turn, helps in the…”
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Whole exome sequencing identifies a novel splice-site mutation in IMPG2 gene causing Stargardt-like juvenile macular dystrophy in a north Indian family by Chatterjee, Souradip, Gupta, Shashank, Chaudhry, Vidya Nair, Chaudhry, Prashaant, Mukherjee, Ashim, Mutsuddi, Mousumi

“…•Stargardt disease is a frequent form of juvenile or early-onset macular dystrophy.•We present genetic dissection of Stargardt-like dystrophy in an Indian…”
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