Search Results - "Mutlib, A"

Late sodium current block for drug-induced long QT syndrome: Results from a prospective clinical trial by Johannesen, L, Vicente, J, Mason, JW, Erato, C, Sanabria, C, Waite-Labott, K, Hong, M, Lin, J, Guo, P, Mutlib, A, Wang, J, Crumb, WJ, Blinova, K, Chan, D, Stohlman, J, Florian, J, Ugander, M, Stockbridge, N, Strauss, DG

“…Drug‐induced long QT syndrome has resulted in many drugs being withdrawn from the market. At the same time, the current regulatory paradigm for screening new…”
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Kinetics of Acetaminophen Glucuronidation by UDP-Glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential Implications in Acetaminophen−Induced Hepatotoxicity by Mutlib, Abdul E, Goosen, Theunis C, Bauman, Jonathan N, Williams, J. Andrew, Kulkarni, Shaila, Kostrubsky, Seva

“…The importance of uridine 5‘-diphosphate-glucuronosyltranferases (UGT) 2B15 and other UGT enzymes (1A1, 1A6, and 1A9) in glucuronidating acetaminophen (APAP)…”
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Identification and Characterization of Efavirenz Metabolites by Liquid Chromatography/Mass Spectrometry and High Field NMR: Species Differences in the Metabolism of Efavirenz by MUTLIB, A. E, CHEN, H, NEMETH, G. A, MARKWALDER, J. A, SEITZ, S. P, GAN, L. S, CHRIST, D. D

“…Efavirenz (Sustiva, Fig. 1 ) is a potent and specific inhibitor of HIV-1 reverse transcriptase approved for the treatment of HIV infection. To examine the…”
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Application of stable isotope labeled glutathione and rapid scanning mass spectrometers in detecting and characterizing reactive metabolites by Mutlib, Abdul, Lam, Wing, Atherton, Jim, Chen, Hao, Galatsis, Paul, Stolle, Wayne

“…The formation of reactive metabolites from a number of compounds was studied in vitro using a mixture of non‐labeled and stable isotope labeled glutathione…”
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Phenobarbital and Phenytoin Increased Acetaminophen Hepatotoxicity Due to Inhibition of UDP-Glucuronosyltransferases in Cultured Human Hepatocytes by Kostrubsky, Seva E., Sinclair, Jacqueline F., Strom, Stephen C., Wood, Sheryl, Urda, Ellen, Stolz, Donna Beer, Wen, Yuan H., Kulkarni, Shaila, Mutlib, Abdul

“…Here we present a preclinical model to assess drug–drug interactions due to inhibition of glucuronidation. Treatment with the antiepileptics phenobarbital (PB)…”
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Transport, Metabolism, and Hepatotoxicity of Flutamide, Drug–Drug Interaction with Acetaminophen Involving Phase I and Phase II Metabolites by Kostrubsky, Seva E, Strom, Stephen C, Ellis, Ewa, Nelson, Sidney D, Mutlib, Abdul E

“…Treatment with flutamide has been associated with clinical hepatotoxicty. The toxicity, metabolism,and transport of flutamide were investigated using cultured…”
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Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine by Bores, G M, Huger, F P, Petko, W, Mutlib, A E, Camacho, F, Rush, D K, Selk, D E, Wolf, V, Kosley, Jr, R W, Davis, L, Vargas, H M

“…Acetylcholinesterase (AChE) inhibitors from several chemical classes have been tested for the symptomatic treatment of Alzheimer's disease; however, the…”
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Application of hyphenated LC/NMR and LC/MS techniques in rapid identification of in vitro and in vivo metabolites of iloperidone by Mutlib, A E, Strupczewski, J T, Chesson, S M

“…Iloperidone, 1(-)[4(-)[3(-)[4-(6-fluro-1,2-benzisoxazol-3-yl)-1- piperidinyl]propoxy]-3-methoxyphenyl]ethanone, is currently undergoing clinical trials as a…”
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Delineating Novel Metabolic Pathways of DPC 963, a Non-Nucleoside Reverse Transcriptase Inhibitor, in Rats. Characterization of Glutathione Conjugates of Postulated Oxirene and Benzoquinone Imine Intermediates by LC/MS and LC/NMR by Chen, Hao, Shockcor, John, Chen, Weiqi, Espina, Robert, Gan, Liang-Shang, Mutlib, A. E

“…The metabolic activation of (S)-5,6-difluoro-4-cyclopropylethynyl-4-trifluoromethyl-3,4-dihydro-2(1H)-quinazolinone, DPC 963, in rats was investigated by…”
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Liquid Chromatography/Mass Spectrometry and High-Field Nuclear Magnetic Resonance Characterization of Novel Mixed Diconjugates of the Non-nucleoside Human Immunodeficiency Virus-1 Reverse Transcriptase Inhibitor, Efavirenz by MUTLIB, A. E, CHEN, H, NEMETH, G, GAN, L.-S, CHRIST, D. D

“…Efavirenz (Sustiva) is a potent and specific inhibitor of the HIV-1 reverse transcriptase and is approved for the treatment of HIV infection. The metabolism of…”
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A comprehensive listing of bioactivation pathways of organic functional groups by Kalgutkar, Amit S, Gardner, Iain, Obach, R Scott, Shaffer, Christopher L, Callegari, Ernesto, Henne, Kirk R, Mutlib, Abdul E, Dalvie, Deepak K, Lee, Jae S, Nakai, Yasuhiro, O'Donnell, John P, Boer, Jason, Harriman, Shawn P

“…The occurrence of idiosyncratic adverse drug reactions during late clinical trials or after a drug has been released can lead to a severe restriction in its…”
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Application of liquid chromatography/mass spectrometry in accelerating the identification of human liver cytochrome P450 isoforms involved in the metabolism of iloperidone by Mutlib, A E, Klein, J T

“…Iloperidone, [1-[4-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]eth anone, 1, is currently undergoing clinical trials as a…”
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Mass spectrometric and NMR characterization of metabolites of roxifiban, a potent and selective antagonist of the platelet glycoprotein IIb/IIIa receptor by Mutlib, A. E., Diamond, S., Shockcor, J., Way, R., Nemeth, G., Gan, L., Christ, D. D.

“…1. The methylester prodrug roxifiban is an orally active, potent and selective antagonist of the platelet glycoprotein GPIIb/IIIa receptor and is being…”
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The Species-Dependent Metabolism of Efavirenz Produces a Nephrotoxic Glutathione Conjugate in Rats by Mutlib, Abdul E., Gerson, Ronald J., Meunier, Paul C., Haley, Patrick J., Chen, Hao, Gan, Lawrence S., Davies, Marc H., Gemzik, Brian, Christ, David D., Krahn, David F., Markwalder, Jay A., Seitz, Steven P., Robertson, Richard T., Miwa, Gerald T.

“…Efavirenz, a potent nonnucleoside reverse transcriptase inhibitor widely prescribed for the treatment of HIV infection, produces renal tubular epithelial cell…”
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Simultaneous quantification of seven active metabolites of roxifiban in human plasma by LC/MS/MS in the presence of an interfering displacer at millimolar concentrations by Shi, G, Lloyd, T.L, Sy, S.K.B, Jiao, Q, Wernicki, A, Mutlib, A, Emm, T.A, Unger, S.E, Pieniaszek, H.J

“…Roxifiban (DMP 754) is a glycoprotein (GP) IIb/IIIa antagonist. Following oral administration to humans, roxifiban is metabolized to its primary active…”
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Metabolism of an atypical antipsychotic agent, 3-[4-[4-(6-fluorobenzo[b]thien-3-yl)-1-piperazinyl]butyl]-2, 5,5-trimethyl-4-thiazolidinone (HP236) by Mutlib, A E, Jurcak, J, Hrib, N

“…Metabolism of an atypical antipsychotic agent, 3-[4-[4-(6-fluorobenzo[b]thien-3-yl)-1-piperazinyl]butyl]-2, 5,5-trimethyl-4-thiazolidinone (HP236) by rats is…”
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Metabolism of Capsaicin by Cytochrome P450 Produces Novel Dehydrogenated Metabolites and Decreases Cytotoxicity to Lung and Liver Cells by Reilly, Christopher A, Ehlhardt, William J, Jackson, David A, Kulanthaivel, Palaniappan, Mutlib, Abdul E, Espina, Robert J, Moody, David E, Crouch, Dennis J, Yost, Garold S

“…Capsaicin is a common dietary constituent and a popular homeopathic treatment for chronic pain. Exposure to capsaicin has been shown to cause various…”
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P450-Mediated Metabolism of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole- 5-carboxamide (DPC 423) and Its Analogues to Aldoximes. Characterization of Glutathione Conjugates of Postulated Intermediates Derived from Aldoximes by Mutlib, Abdul E, Chen, Shiang-Yuan, Espina, Robert J, Shockcor, John, Prakash, Shimoga R, Gan, Liang-Shang

“…The in vivo and in vitro disposition of DPC 423, a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa, has recently…”
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Isolation and characterization of carbinolamide and phenolic glucuronide conjugates of (+-)-N-methyl-N-(1-methyl-3,3-diphenylpropyl) formamide and N-formylmethamphetamine by FAB/MS, LC/MS/MS, and NMR by Mutlib, A E, Abbott, F S

“…The metabolic disposition of (+-)-N-methyl-N-(1-methyl-3,3- diphenyl-propyl)formamide, especially with regard to the formation of water soluble glucuronides,…”
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Bioactivation of Benzylamine to Reactive Intermediates in Rodents:  Formation of Glutathione, Glutamate, and Peptide Conjugates by Mutlib, Abdul E, Dickenson, Patricia, Chen, Shiang-Yuan, Espina, Robert J, Daniels, J. Scott, Gan, Liang-Shang

“…The in vivo and in vitro disposition of benzylamine was investigated in rats. Benzylamine was metabolized to only a small extent by rat liver subcellular…”
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