Search Results - "Mutisya, Daniel"

Therapeutic potential of chemically modified siRNA: Recent trends by Selvam, Chelliah, Mutisya, Daniel, Prakash, Sandhya, Ranganna, Kasturi, Thilagavathi, Ramasamy

“…Small interfering RNAs (siRNAs) are one of the valuable tools to investigate the functions of genes and are also used for gene silencing. It has a wide scope…”
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Amides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAs by Mutisya, Daniel, Selvam, Chelliah, Lunstad, Benjamin D, Pallan, Pradeep S, Haas, Amanda, Leake, Devin, Egli, Martin, Rozners, Eriks

“…RNA interference (RNAi) has become an important tool in functional genomics and has an intriguing therapeutic potential. However, the current design of short…”
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Economic advantage of sorghum harvest at soft dough grain stage to prevent bird damage by Mutisya, Daniel L., Karanja, David R., Kisilu, Rachael K.

“…Sorghum grain yield is highly reduced by birds in most areas in Africa where these avian pests are abundant. After much consideration on the physiological…”
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Quality of field collected and laboratory reared Chilo partellus (Swinhoe) (Lepidoptera: Crambidae) for screening maize genotypes by Daniel, L Mutisya, Tadele, Tefera, Stephen, Mugo

“…The quality of laboratory reared stem borer species for screening of maize varieties is usually questioned by end user cereal breeders. A quality check study…”
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Pterocarpan scaffold: A natural lead molecule with diverse pharmacological properties by Selvam, Chelliah, Jordan, Brian C., Prakash, Sandhya, Mutisya, Daniel, Thilagavathi, Ramasamy

“…Phytoalexins are substances produced by plants that act as potent inhibitors of pathogens. Pterocarpans are biologically active isoflavonoids most commonly…”
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Optimizing the timing of management interventions against fall armyworm in African smallholder maize: Modelling the pattern of larval population emergence and development by Lowry, Alyssa, Durocher-Granger, Léna, Oronje, MaryLucy, Mutisya, Daniel, Mfune, Tibonge, Gitonga, Christine, Musesha, Monde, Taylor, Bryony, Wood, Suzy, Chacha, Duncan, Beale, Tim, Finch, Elizabeth A., Murphy, Sean T.

“…Since its invasion in late 2016, the fall armyworm has a widespread year-round distribution within Africa where it continues to threaten cereal production,…”
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Therapeutic potential of chemically modified si RNA : Recent trends by Selvam, Chelliah, Mutisya, Daniel, Prakash, Sandhya, Ranganna, Kasturi, Thilagavathi, Ramasamy

“…Small interfering RNA s (si RNA s) are one of the valuable tools to investigate the functions of genes and are also used for gene silencing. It has a wide…”
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Amide linkages mimic phosphates in RNA interactions with proteins and are well tolerated in the guide strand of short interfering RNAs by Mutisya, Daniel, Hardcastle, Travis, Cheruiyot, Samwel K, Pallan, Pradeep S, Kennedy, Scott D, Egli, Martin, Kelley, Melissa L, Smith, Anja van Brabant, Rozners, Eriks

“…While the use of RNA interference (RNAi) in molecular biology and functional genomics is a well-established technology, in vivo applications of synthetic short…”
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A Single Amide Linkage in the Passenger Strand Suppresses Its Activity and Enhances Guide Strand Targeting of siRNAs by Hardcastle, Travis, Novosjolova, Irina, Kotikam, Venubabu, Cheruiyot, Samwel K, Mutisya, Daniel, Kennedy, Scott D, Egli, Martin, Kelley, Melissa L, Smith, Anja van Brabant, Rozners, Eriks

“…Potential in vivo applications of RNA interference (RNAi) require suppression of various off-target activities. Herein, we report that replacement of a single…”
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Synthesis and properties of triazole-linked RNA by Mutisya, Daniel, Selvam, Chelliah, Kennedy, Scott D., Rozners, Eriks

“…RNA oligonucleotides having triazole linkages between uridine and adenosine nucleosides have been prepared and studied using spectroscopic techniques. UV…”
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Forecasting the population development of within-season insect crop pests in sub-Saharan Africa: the Pest Risk Information Service by Day, Charlotte, Murphy, Sean T, Styles, Jon, Taylor, Bryony, Beale, Tim, Holland, William, Williams, Frances, Shaw, Andy, Finegold, Cambria, Oronje, MaryLucy, Oppong-Mensah, Birgitta, Phiri, Noah, Lowry, Alyssa, Finch, Elizabeth A, Mahony, Josephine, Wood, Suzy, Durocher-Granger, Léna, Chacha, Duncan, Maczey, Norbert, Gonzalez-Moreno, Pablo, Thomas, Sarah E, Beeken, Joe, Lewis, Jane, Saldana, Gerado Lopez, Duah, Solomon, Bundi, Mary, Wasilwa, Lusike, Amata, Ruth, Musila, Ruth, Mutisya, Daniel, Gitonga, Christine K, Kalama, Patrick, Nyasani, Johnson O, Matimelo, Matthews, Mgomba, Henry, Gaitu, Christopher, Ocloo, Christopher, Adjei-Mensah, Isaac, Ohene-Mensah, Godfried, Nboyine, Jerry Asalma, Susuwele, Blessings

“…Smallholder farmers are the mainstay of the agricultural economies of sub-Saharan Africa (SSA), where they produce several crops, predominantly centered on…”
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A novel siRNA–gemcitabine construct as a potential therapeutic for treatment of pancreatic cancer by Simonenko, Vera, Lu, Xiaoyong, Roesch, Eric, Mutisya, Daniel, Shao, Chunbo, Sun, Qian, Patterson-Orazem, Athéna, McNair, Marcus, Shanmuganathan, Aranganathan, Lu, Patrick, Evans, David M

“…The non-nucleoside analog gemcitabine has been the standard of care for treating pancreatic cancer. The drug shows good potency in pancreatic cancer cells in…”
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Predatory phytoseiid mites associated with cassava in Kenya, identification key and molecular diagnosis (Acari: Phytoseiidae by Mutisya, Daniel L., El-Banhawy El Sayed, M., Vicente dos Santos, Victor, Kariuki, Charles W., Khamala, Cannute P.M.., Tixier, Marie-Stéphane

“…The objective of this study was to carry out a large survey in order to characterize Phytoseiidae species diversity on cassava in Kenya. A total of 29 species…”
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Predatory phytoseiid mites associated with cassava in Kenya, identification key and molecular diagnosis (Acari: Phytoseiidae) by Mutisya, Daniel L., El-Banhawy, El Sayed M., Vicente dos Santos, Victor, Kariuki, Charles W., Khamala, Cannute P.M.., Tixier, Marie-Stéphane

“…The objective of this study was to carry out a large survey in order to characterize Phytoseiidae species diversity on cassava in Kenya. A total of 29 species…”
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Synthesis, biophysical properties and biological activities of non-ionic RNA analogues having triazole and amide internucleoside linkages by Mutisya, Daniel Mwambia

“…The potential of RNA interference to become a new therapeutic approach has prompted interest in chemical modifications of RNA. Nonionic backbone modifications…”
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Typhlodromalus aripo De Leon (Acari: Phytoseiidae) development and reproduction on major cassava pests at different temperatures and humidities: an indication of enhanced mite resilience by Mutisya, D.L., El-Banhawy, E.M., Kariuki, C.W., Khamala, C.P.M.

“…Both prey type and abiotic conditions limit performance of phytoseiid predators. The exotic predatory mite, Typhlodromalus aripo developed and reproduced when…”
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Synthesis, biophysical properties and biological activities of non-ionic RNA analogues having triazole and amide internucleoside linkages by Mutisya, Daniel Mwambia

“…The potential of RNA interference to become a new therapeutic approach has prompted interest in chemical modifications of RNA. Nonionic backbone modifications…”
Get full text