Search Results - "Muthusamy, Ramesh"

Molecular Modeling Studies on Cytochrome P450-mediated Drug Metabolism by Muthusamy, Ramesh, Bharatam, Prasad V

“…Drug metabolism studies play a critical role in the optimization of the therapeutic efficacy of newer drug candidates. Many drug candidates and drugs were…”
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Ischemic-reperfusion of unilateral external iliac artery in rat: A new model for vasculitic femoral neuropathy by Muthuraman, Arunachalam, Ramesh, Muthusamy

“…•Rat model of vasculitic femoral neuropathy (VFN) was developed by I/R injury.•This model produces the similar kind of neuropathic pain symptoms in human.•VFN…”
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Therapeutic Investigation of Palm Oil Mill Effluent-Derived Beta-Carotene in Streptozotocin-Induced Diabetic Retinopathy via the Regulation of Blood-Retina Barrier Functions by Paramaswaran, Yamunna, Subramanian, Aswinprakash, Paramakrishnan, Nallupillai, Ramesh, Muthusamy, Muthuraman, Arunachalam

“…Diabetic retinopathy (DR) primarily progresses into retinal degeneration caused by microvascular dysfunction. The pathophysiology of DR progression is still…”
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In Silico and In Vitro Methods in the Characterization of Beta-Carotene as Pharmaceutical Material via Acetylcholine Esterase Inhibitory Actions by Muthuraman, Arunachalam, Ramesh, Muthusamy, Mustaffa, Fazlina, Nadeem, Ahmed, Nishat, Shamama, Paramakrishnan, Nallupillai, Lim, Khian Giap

“…Molecular docking is widely used in the assessment of the therapeutic potential of pharmaceutical agents. The binding properties of beta-carotene (BC) to…”
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Formation of a Toxic Quinoneimine Metabolite from Diclofenac: A Quantum Chemical Study by Ramesh, Muthusamy, Bharatam, Prasad V

“…Diclofenac is a non-steroidal antiinflammatory drug. It is predominantly metabolized by CYP2C9. 4'-hydroxydiclofenac and its quinoneimine are the metabolites…”
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Drug therapy of neuropathic pain: current developments and future perspectives by Muthuraman, Arunachalam, Singh, Nirmal, Jaggi, Amteshwar Singh, Ramesh, Muthusamy

“…Understanding mechanism of neuropathic pain is too complex and involves both peripheral and central pathophysiological phenomenon. Accordingly the treatment of…”
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Per-residue energy decomposition pharmacophore model to enhance virtual screening in drug discovery: a study for identification of reverse transcriptase inhibitors as potential anti-HIV agents by Cele, Favourite N, Ramesh, Muthusamy, Soliman, Mahmoud Es

“…A novel virtual screening approach is implemented herein, which is a further improvement of our previously published "target-bound pharmacophore modeling…”
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Therapeutic, Molecular and Computational Aspects of Novel Monoamine Oxidase (MAO) Inhibitors by Ramesh, Muthusamy, Dokurugu, Yussif M, Thompson, Michael D, Soliman, Mahmoud E

“…Background Due to the limited number of MAO inhibitors in the clinics, several research efforts are aimed at the discovery of novel MAO inhibitors. At present,…”
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Induction of Caspase-Mediated Apoptosis in HepG2 Liver Carcinoma Cells Using Mutagen-Antioxidant Conjugated Self-Assembled Novel Carbazole Nanoparticles and In Silico Modeling Studies by Anand, Krishnan, Abdul, Naeem Sheik, Ghazi, Terisha, Ramesh, Muthusamy, Gupta, Gaurav, Tambuwala, Murtaza M, Dureja, Harish, Singh, Sachin Kumar, Chellappan, Dinesh Kumar, Dua, Kamal, Pandi, Boomi, Saravanan, Muthupandian, Chuturgoon, Anil Amichund

“…In this study, novel self-assembled carbazole-thiooctanoic acid nanoparticles (CTNs) were synthesized from amino carbazole (a mutagen) and thiooctanoic acid…”
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Recent advancements in the development of anti-tuberculosis drugs by Chetty, Sarentha, Ramesh, Muthusamy, Singh-Pillay, Ashona, Soliman, Mahmoud E.S.

“…[Display omitted] •Tuberculosis is a highly infectious disease and is caused by the pathogen Mycobacterium tuberculosis.•The recent advancements in the…”
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Synthesis, molecular docking, antimicrobial, antioxidant and toxicity assessment of quinoline peptides by Thangaraj, Muthu, Gengan, Robert Moonsamy, Ranjan, Bibhuti, Muthusamy, Ramesh

“…A series of quinoline based peptides were synthesized by a one-pot reaction through Ugi-four component condensation of lipoic acid, cyclohexyl isocyanide,…”
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Convalescent serum-derived exosomes: Attractive niche as COVID-19 diagnostic tool and vehicle for mRNA delivery by Krishnan, Anand, Gangadaran, Prakash, Chavda, Vivek P, Jogalekar, Manasi P, Muthusamy, Ramesh, Valu, Disha, Vadivalagan, Chithravel, Ramani, Prasanna, Laishevtcev, Alexey, Katari, Naresh Kumar, Ahn, Byeong-Cheol

“…The spread of SARS-CoV-2 over the entire world is more commonly known as COVID-19. COVID-19 has impacted society in every aspect of routine life. SARS-CoV-2…”
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Ameliorative potential of montelukast on ischemia–reperfusion injury induced vasculitic neuropathic pain in rat by Muthuraman, Arunachalam, Ramesh, Muthusamy, Sood, Shailja

“…Ischemia -reperfusion (I/R) event in vascular and nervous system has been documented to rising ischemic and vasculitic neuropathic pain, clinically resembles…”
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Development of animal model for vasculatic neuropathy: Induction by ischemic-reperfusion in the rat femoral artery by Muthuraman, Arunachalam, Ramesh, Muthusamy, Sood, Shailja

“…Ischemic-reperfusion (I/R) is common in various pathological conditions like diabetic complication, complex regional pain syndrome type II (CRPS II),…”
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Sequence, Structural Analysis and Metrics to Define the Unique Dynamic Features of the Flap Regions Among Aspartic Proteases by McGillewie, Lara, Ramesh, Muthusamy, Soliman, Mahmoud E.

“…Aspartic proteases are a class of hydrolytic enzymes that have been implicated in a number of diseases such as HIV, malaria, cancer and Alzheimer’s. The flap…”
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One-step synthesis of picolinohydrazides from fusaric acid: DFT, structural characterization and molecular inhibitory studies on metastatic tumor-derived exosomal and non-exosomal proteins by Anand, Krishnan, Ramesh, Muthusamy, Singh, Thishana, Balakumar, Chandrasekaran, Chithravel, Vadivalagan, Prasher, Parteek, Katari, Naresh Kumar, Gupta, Gaurav, Singh, Sachin Kumar, Chellappan, Dinesh Kumar, Dua, Kamal, Chavda, Vivek, Laishevtcev, Alexey, Shahbaaz, Mohd, Abdellattif, Magda H., Saravanan, Muthupandian, Chuturgoon, Anil A.

“…•One-step synthesis of picolinohydrazides from mycotoxin fusaric acid.•Synthetic molecules experimental results compared with theoretical results by…”
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An efficient implementation of novel Paillier encryption with polar encoder for 5G systems in VLSI by Ganesan, Indumathi, Balasubramanian, Aarthi Alias Ananthakirupa, Muthusamy, Ramesh

“…•A novel design of Paillier encryption with polar encoding is proposed.•A new cross-partitioned add shift processing element is designed for the realization of…”
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Microwave Synthesis of Fused Pyrans by Humic Acid Supported Ionic Liquid Catalyst and Their Antimicrobial, Antioxidant, Toxicity Assessment, and Molecular Docking Studies by Thangaraj, Muthu, Ranjan, Bibhuti, Muthusamy, Ramesh, Murugesan, Arul, Gengan, Robert Moonsamy

“…A series of fused quinolinyl and quinolonyl pyrans were synthesized via a one‐pot reaction of quinolinyl and quinolonyl carbaldehydes, malononitrile, and a…”
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Mitochondrial Dependent Apoptosis: Ameliorative Effect of Flunarizine on Ischemia–Reperfusion of Celiac Artery-Induced Gastric Lesions in the Rat by Muthuraman, Arunachalam, Ramesh, Muthusamy, Chauhan, Ashish

“…Objectives Ischemia–reperfusion is a major event for induction of cellular apoptosis. Apoptosis is due to the activation of death receptor and/or mitochondrial…”
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Physiological and Pathophysiological Role of Cysteine Metabolism in Human Metabolic Syndrome by Muthuraman, Arunachalam, Ramesh, Muthusamy, Shaikh, Sohrab A, Aswinprakash, Subramanian, Jagadeesh, Dhamodharan

“…Cysteine is one of the major intermediate products of cellular amino-acid metabolism. It is a semi-essential amino acid for protein synthesis. Besides, it is…”
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