Expression pattern of p63 in oral epithelial lesions and submucous fibrosis associated with betel-quid chewing in Sri Lanka

Betel-quid chewing, which is closely related to the high incidence of oral cancer, is prevalent in Sri Lanka. p63 has a remarkable structural similarity to p53, suggesting an aberrant expression in oral cancer. Using anti-p63 antibody and immunohistochemistry, the present study investigated the expr...

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Published in:	Medical molecular morphology Vol. 40; no. 4; pp. 203 - 207
Main Authors:	Haniffa, Abusayeed M, Saitoh, Masato, Abiko, Yoshihiro, Takeshima, Maiko, Nishimura, Michiko, Yamazaki, Mami, Nagayasu, Hiroki, Sugiura, Chihiro, Muthumala, Malantha, Kaku, Tohru, Chiba, Itsuo, Shibata, Toshiyuki
Format:	Journal Article
Language:	English
Published:	Japan Springer Nature B.V 01-12-2007
Subjects:	Adult Areca - metabolism Cellular biology DNA-Binding Proteins - metabolism Epithelium - metabolism Epithelium - pathology Gene expression Head & neck cancer Humans Immunohistochemistry Immunology Ki-67 Antigen - metabolism Mastication - physiology Middle Aged Molecular biology Mouth Mucosa - pathology Mouth Neoplasms - metabolism Mutation Oral Submucous Fibrosis - metabolism Sri Lanka Trans-Activators - metabolism Transcription Factors Tumor Suppressor Proteins - metabolism Sri Lanka
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Summary:	Betel-quid chewing, which is closely related to the high incidence of oral cancer, is prevalent in Sri Lanka. p63 has a remarkable structural similarity to p53, suggesting an aberrant expression in oral cancer. Using anti-p63 antibody and immunohistochemistry, the present study investigated the expression pattern of p63 in oral epithelial lesions, including different types of squamous cell carcinoma (SCC), different grades of epithelial dysplasia, and submucosal fibrosis associated with betel-quid chewing. Nuclear immunoreactivity for p63 was detected in all the cases, including normal oral epithelium and epithelial lesions. In normal oral epithelium, nuclear positivity for p63 was observed in some of the basal cell layers and focally in the parabasal layer. Nuclear positivity increased in the epithelial lesions. The percentage of positive nuclei in the epithelial lesions was significantly higher than in normal epithelium (P < 0.01) and was also significantly higher in oral submucosal fibrosis than in epithelial dysplasia (P < 0.05). The results indicate that the overexpression of p63 in oral precancerous lesions and SCC in betel-quid chewers in Sri Lanka may be a useful marker for oral precancerous lesions.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1860-1480 1860-1499
DOI:	10.1007/s00795-007-0383-6