Search Results - "Muthukumarasamy, Kalai Mangai"
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Deciphering the role of hydrophobic and hydrophilic bile acids in angiogenesis using in vitro and in vivo model systems
Published in MedChemComm (01-12-2017)“…Bile acids have emerged as strong signaling molecules capable of influencing various biological processes like inflammation, apoptosis, cancer progression and…”
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Mechanisms of Action of the KCa2-Negative Modulator AP30663, a Novel Compound in Development for Treatment of Atrial Fibrillation in Man
Published in Frontiers in pharmacology (06-05-2020)“…Small conductance Ca -activated K channels (SK channels, K 2) are a new target for treatment of atrial fibrillation (AF). AP30663 is a small molecule inhibitor…”
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Impact of arrhythmogenic calmodulin variants on small conductance Ca2+‐activated K+ (SK3) channels
Published in Physiological reports (01-10-2019)“…Calmodulin (CaM) is a ubiquitous Ca2+‐sensing protein regulating many important cellular processes. Several CaM‐associated variants have been identified in a…”
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The KCa2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts
Published in Frontiers in pharmacology (19-06-2019)“…Background and Purpose: Prolongation of cardiac action potentials is considered antiarrhythmic in the atria but can be proarrhythmic in ventricles if the…”
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Impact of arrhythmogenic calmodulin variants on small conductance Ca 2+ -activated K + (SK3) channels
Published in Physiological reports (01-10-2019)“…Calmodulin (CaM) is a ubiquitous Ca -sensing protein regulating many important cellular processes. Several CaM-associated variants have been identified in a…”
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Daily exposure to chlordecone, an organochlorine pesticide, increases cardiac fibrosis and atrial fibrillation vulnerability
Published in Journal of hazardous materials (05-10-2024)“…Chlordecone (CLD) is a carcinogenic organochlorine pesticide. CLD was shown to disturb the activity of cardiac Na+-K+-ATPase and Ca2+-Mg2+-ATPase. Conditions…”
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Identification of noreremophilane-based inhibitors of angiogenesis using zebrafish assays
Published in Organic & biomolecular chemistry (07-02-2016)“…Noreremophilanes are a rare class of cis-hydrindanes produced by genus Ligularia herbaceous plants which are known to exhibit interesting biological…”
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The K Ca 2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts
Published in Frontiers in pharmacology (2019)“…Prolongation of cardiac action potentials is considered antiarrhythmic in the atria but can be proarrhythmic in ventricles if the current carried by…”
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