Search Results - "Muthukumar, Yazh"

Copy-choice recombination during mitochondrial L-strand synthesis causes DNA deletions by Persson, Örjan, Muthukumar, Yazh, Basu, Swaraj, Jenninger, Louise, Uhler, Jay P., Berglund, Anna-Karin, McFarland, Robert, Taylor, Robert W., Gustafsson, Claes M., Larsson, Erik, Falkenberg, Maria

“…Mitochondrial DNA (mtDNA) deletions are associated with mitochondrial disease, and also accumulate during normal human ageing. The mechanisms underlying mtDNA…”
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Investigations on the mode of action of gephyronic acid, an inhibitor of eukaryotic protein translation from myxobacteria by Muthukumar, Yazh, Münkemer, Johanna, Mathieu, Daniel, Richter, Christian, Schwalbe, Harald, Steinmetz, Heinrich, Kessler, Wolfgang, Reichelt, Joachim, Beutling, Ulrike, Frank, Ronald, Büssow, Konrad, van den Heuvel, Joop, Brönstrup, Mark, Taylor, Richard E, Laschat, Sabine, Sasse, Florenz

“…The identification of inhibitors of eukaryotic protein biosynthesis, which are targeting single translation factors, is highly demanded. Here we report on a…”
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Novel peptidomimetic compounds containing redox active chalcogens and quinones as potential anticancer agents by Shaaban, Saad, Diestel, Randi, Hinkelmann, Bettina, Muthukumar, Yazh, Verma, Rajeshwar P., Sasse, Florenz, Jacob, Claus

“…Many types of cancer cells are associated with a disturbed intracellular redox balance and oxidative stress (OS). Among the various agents employed to modulate…”
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Cytotoxic and antivascular 1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(halophenyl)-imidazoles by Biersack, Bernhard, Muthukumar, Yazh, Schobert, Rainer, Sasse, Florenz

“…A series of 1-methyl-4,5-diphenylimidazoles 6 with various patterns of m-halogen substitution at the 5-phenyl ring were tested for cytotoxicity in cancer and…”
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An Improved Route to (+)-Tedanolide and Analysis of Its Subtle Effects Controlling Conformation and Biological Behaviour by Diaz, Nina, Zhu, Mingzhao, Ehrlich, Gunnar, Eggert, Ulrike, Muthukumar, Yazh, Sasse, Florenz, Kalesse, Markus

“…The improved synthesis of the antitumor compound (+)‐tedanolide is described through an aldol coupling of bis‐ketone 7. This modification shortens the…”
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The Marine Polyketide Myriaporone 3/4 Stalls Translation by Targeting the Elongation Phase by Muthukumar, Yazh, Roy, Myriam, Raja, Aruna, Taylor, Richard E., Sasse, Florenz

“…Myriaporone 3/4, a cytotoxic polyketide, has been reported as an inhibitor of eukaryotic protein synthesis. However, the mechanism by which it inhibits…”
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The Synthesis and Biological Evaluation of Desepoxyisotedanolide and a Comparison with Desepoxytedanolide by Naini, Arun, Muthukumar, Yazh, Raja, Aruna, Franke, Raimo, Harrier, Ian, Smith III, Amos B., Lee, Dongjoo, Taylor, Richard E., Sasse, Florenz, Kalesse, Markus

“…The tedanolides are biologically active polyketides that exhibit a macrolactone constructed from a primary alcohol. Since polyketidal transformations only…”
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Synthesis of Simplified Tedanolide Analogues-Connecting Tedanolide to Myriaporone and Gephyronic Acid by Diaz, Nina, Naini, Arun, Muthukumar, Yazh, Sasse, Florenz, Kalesse, Markus

“…Southern belles! Simplified analogues of tedanolide, a natural product with picomolar activity against a range of tumor cell lines, were synthesized and…”
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Synthesis and Biological Evaluation of Gephyronic Acid Derivatives: Initial Steps towards the Identification of the Biological Target of Polyketide Inhibitors of Eukaryotic Protein Synthesis by Anderl, Timo, Nicolas, Lionel, Münkemer, Johanna, Muthukumar, Yazh, Baro, Angelika, Frey, Wolfgang, Sasse, Florenz, Taylor, Richard E., Laschat, Sabine

“…Coupled to the development of a total synthesis of gephyronic acid, a series of diastereomeric analogues and their precursors have been prepared by employing…”
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Screening of small molecules affecting mammalian P-body assembly uncovers links with diverse intracellular processes and organelle physiology by Martínez, Javier P, Pérez-Vilaró, Gemma, Muthukumar, Yazh, Scheller, Nicoletta, Hirsch, Tatjana, Diestel, Randi, Steinmetz, Heinrich, Jansen, Rolf, Frank, Ronald, Sasse, Florenz, Meyerhans, Andreas, Díez, Juana

“…Processing bodies (P-bodies) are cytoplasmatic mRNP granules containing non-translating mRNAs and proteins from the mRNA decay and silencing machineries. The…”
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Die Synthese und biologische Validierung von Desepoxyisotedanolid und dessen Vergleich mit Desepoxytedanolid by Naini, Arun, Muthukumar, Yazh, Raja, Aruna, Franke, Raimo, Harrier, Ian, Smith, Amos B., Lee, Dongjoo, Taylor, Richard E., Sasse, Florenz, Kalesse, Markus

“…Die Tedanolide sind biologisch aktive Polyketide, deren Makrolaktonring aus einem primären Alkohol aufgebaut ist. Da Polyketidumwandlungen nur sekundäre…”
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Die Synthese und biologische Validierung von Desepoxyisotedanolid und dessen Vergleich mit Desepoxytedanolid by Naini, Arun, Muthukumar, Yazh, Raja, Aruna, Franke, Raimo, Harrier, Ian, Smith III, Amos B., Lee, Dongjoo, Taylor, Richard E., Sasse, Florenz, Kalesse, Markus

“…Abstract Die Tedanolide sind biologisch aktive Polyketide, deren Makrolaktonring aus einem primären Alkohol aufgebaut ist. Da Polyketidumwandlungen nur…”
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Screening of small molecules affecting mammalian P-body assembly uncovers links with diverse intracellular processes and organelle physiology by Martínez, Javier P, Pérez-Vilaró, Gemma, Muthukumar, Yazh, Scheller, Nicoletta, Hirsch, Tatjana, Diestel, Randi, Steinmetz, Heinrich, Jansen, Rolf, Frank, Ronald, Sasse, Florenz, Meyerhans, Andreas, Díez, Juana

“…Processing bodies (P-bodies) are cytoplasmatic mRNP granules containing non-translating mRNAs and proteins from the mRNA decay and silencing machineries. The…”
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