Search Results - "Muthas, Daniel"

Activation of group 2 innate lymphoid cells after allergen challenge in asthmatic patients by Winkler, Carla, Hochdörfer, Thomas, Israelsson, Elisabeth, Hasselberg, Annemarie, Cavallin, Anders, Thörn, Kristofer, Muthas, Daniel, Shojaee, Shervin, Lüer, Katrin, Müller, Meike, Mjösberg, Jenny, Vaarala, Outi, Hohlfeld, Jens, Pardali, Katerina

“…Group 2 innate lymphoid cells (ILC2s) are effective producers of IL-5 and IL-13 during allergic inflammation and bridge the innate and adaptive immune…”
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Proteomic profiling of serum identifies a molecular signature that correlates with clinical outcomes in COPD by Rania Dagher, Paul Fogel, Jingya Wang, David Soussan, Chia-Chien Chiang, Jennifer Kearley, Daniel Muthas, Camille Taillé, Patrick Berger, Arnaud Bourdin, Cécile Chenivesse, Sylvie Leroy, Gary Anderson, Alison A Humbles, Michel Aubier, Roland Kolbeck, Marina Pretolani, COBRA Consortium

“…ObjectiveNovel biomarkers related to main clinical hallmarks of Chronic obstructive pulmonary disease (COPD), a heterogeneous disorder with pulmonary and…”
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Bleomycin hydrolase regulates the release of chemokines important for inflammation and wound healing by keratinocytes by Riise, Rebecca, Odqvist, Lina, Mattsson, Johan, Monkley, Susan, Abdillahi, Suado M., Tyrchan, Christian, Muthas, Daniel, Yrlid, Linda Fahlén

“…Bleomycin hydrolase (BLMH) is a well-conserved cysteine protease widely expressed in several mammalian tissues. In skin, which contains high levels of BLMH,…”
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Dysregulation of COVID-19 related gene expression in the COPD lung by Watson, Alastair, Öberg, Lisa, Angermann, Bastian, Spalluto, C Mirella, Hühn, Michael, Burke, Hannah, Cellura, Doriana, Freeman, Anna, Muthas, Daniel, Etal, Damla, Belfield, Graham, Karlsson, Fredrik, Nordström, Karl, Ostridge, Kris, Staples, Karl J, Wilkinson, Tom

“…Chronic obstructive pulmonary disease (COPD) patients are at increased risk of poor outcome from Coronavirus disease (COVID-19). Early data suggest elevated…”
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Fungal Dysbiosis and Intestinal Inflammation in Children With Beta-Cell Autoimmunity by Honkanen, Jarno, Vuorela, Arja, Muthas, Daniel, Orivuori, Laura, Luopajärvi, Kristiina, Tejesvi, Mysore Vishakante Gowda, Lavrinienko, Anton, Pirttilä, Anna Maria, Fogarty, Christopher L, Härkönen, Taina, Ilonen, Jorma, Ruohtula, Terhi, Knip, Mikael, Koskimäki, Janne J, Vaarala, Outi

“…Although gut bacterial dysbiosis is recognized as a regulator of beta-cell autoimmunity, no data is available on fungal dysbiosis in the children at the risk…”
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Evaluation of the use of imaging parameters for the detection of compound-induced hepatotoxicity in 384-well cultures of HepG2 cells and cryopreserved primary human hepatocytes by Garside, Helen, Marcoe, Karen F., Chesnut-Speelman, Jessica, Foster, Alison J., Muthas, Daniel, Gerry Kenna, J., Warrior, Usha, Bowes, Joanne, Baumgartner, James

“…•Assessment of 108 DILI and 26 non-DILI drugs in 384-well plate assays.•Key parameters were measured in HepG2 cells ± rat S9 and primary human…”
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Proteomic profiling of serum identifies a molecular signature that correlates with clinical outcomes in COPD by Dagher, Rania, Fogel, Paul, Wang, Jingya, Soussan, David, Chiang, Chia-Chien, Kearley, Jennifer, Muthas, Daniel, Taillé, Camille, Berger, Patrick, Bourdin, Arnaud, Chenivesse, Cécile, Leroy, Sylvie, Anderson, Gary, Humbles, Alison A, Aubier, Michel, Kolbeck, Roland, Pretolani, Marina

“…Novel biomarkers related to main clinical hallmarks of Chronic obstructive pulmonary disease (COPD), a heterogeneous disorder with pulmonary and…”
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Identification of a missense variant in SPDL1 associated with idiopathic pulmonary fibrosis by Dhindsa, Ryan S., Mattsson, Johan, Nag, Abhishek, Wang, Quanli, Wain, Louise V., Allen, Richard, Wigmore, Eleanor M., Ibanez, Kristina, Vitsios, Dimitrios, Deevi, Sri V. V., Wasilewski, Sebastian, Karlsson, Maria, Lassi, Glenda, Olsson, Henric, Muthas, Daniel, Monkley, Susan, Mackay, Alex, Murray, Lynne, Young, Simon, Haefliger, Carolina, Maher, Toby M., Belvisi, Maria G., Jenkins, Gisli, Molyneaux, Philip L., Platt, Adam, Petrovski, Slavé

“…Idiopathic pulmonary fibrosis (IPF) is a fatal disorder characterised by progressive, destructive lung scarring. Despite substantial progress, the genetic…”
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Multiomics links global surfactant dysregulation with airflow obstruction and emphysema in COPD by Hristova, Ventzislava A, Watson, Alastair, Chaerkady, Raghothama, Glover, Matthew S, Ackland, Jodie, Angerman, Bastian, Belfield, Graham, Belvisi, Maria G, Burke, Hannah, Cellura, Doriana, Clark, Howard W, Etal, Damla, Freeman, Anna, Heinson, Ashley I, Hess, Sonja, Hühn, Michael, Hall, Emily, Mackay, Alex, Madsen, Jens, McCrae, Christopher, Muthas, Daniel, Novick, Steven, Ostridge, Kristoffer, Öberg, Lisa, Platt, Adam, Postle, Anthony D, Spalluto, C Mirella, Vaarala, Outi, Wang, Junmin, Staples, Karl J, Wilkinson, Tom M A

“…Pulmonary surfactant is vital for lung homeostasis as it reduces surface tension to prevent alveolar collapse and provides essential immune-regulatory and…”
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Scope and Limitations of Baird's Theory on Triplet State Aromaticity: Application to the Tuning of Singlet-Triplet Energy Gaps in Fulvenes by Ottosson, Henrik, Kilså, Kristine, Chajara, Khalil, Piqueras, Mari Carmen, Crespo, Raül, Kato, Haruhisa, Muthas, Daniel

“…Utilizing Baird's theory on triplet state aromaticity, we show that the singlet–triplet energy gaps (ΔEST) of pentafulvenes are easily varied through…”
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Synthesis, biological evaluation, and modeling studies of inhibitors aimed at the malarial proteases plasmepsins I and II by Muthas, Daniel, Nöteberg, Daniel, Sabnis, Yogesh A., Hamelink, Elizabeth, Vrang, Lotta, Samuelsson, Bertil, Karlén, Anders, Hallberg, Anders

“…The increasing resistance of the malarial parasite to antimalarial drugs is a major contributor to the reemergence of the disease and increases the need for…”
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Rare variant contribution to human disease in 281,104 UK Biobank exomes by Wang, Quanli, Dhindsa, Ryan S., Carss, Keren, Harper, Andrew R., Nag, Abhishek, Tachmazidou, Ioanna, Vitsios, Dimitrios, Deevi, Sri V. V., Mackay, Alex, Muthas, Daniel, Hühn, Michael, Monkley, Susan, Olsson, Henric, Wasilewski, Sebastian, Smith, Katherine R., March, Ruth, Platt, Adam, Haefliger, Carolina, Petrovski, Slavé

“…Genome-wide association studies have uncovered thousands of common variants associated with human disease, but the contribution of rare variants to common…”
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Neutrophils in ulcerative colitis: a review of selected biomarkers and their potential therapeutic implications by Muthas, Daniel, Reznichenko, Anna, Balendran, Clare A., Böttcher, Gerhard, Clausen, Ib Groth, Kärrman Mårdh, Carina, Ottosson, Tomas, Uddin, Mohib, MacDonald, Thomas T., Danese, Silvio, Berner Hansen, Mark

“…Objectives: This review article describes the role of neutrophils in mucosal injury and the resulting crypt abscesses characteristic of ulcerative colitis. We…”
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Unexplored therapeutic opportunities in the human genome by Oprea, Tudor I., Bologa, Cristian G., Brunak, Søren, Campbell, Allen, Gan, Gregory N., Gaulton, Anna, Gomez, Shawn M., Guha, Rajarshi, Hersey, Anne, Holmes, Jayme, Jadhav, Ajit, Jensen, Lars Juhl, Johnson, Gary L., Karlson, Anneli, Leach, Andrew R., Ma'ayan, Avi, Malovannaya, Anna, Mani, Subramani, Mathias, Stephen L., McManus, Michael T., Meehan, Terrence F., von Mering, Christian, Muthas, Daniel, Nguyen, Dac-Trung, Overington, John P., Papadatos, George, Qin, Jun, Reich, Christian, Roth, Bryan L., Schürer, Stephan C., Simeonov, Anton, Sklar, Larry A., Southall, Noel, Tomita, Susumu, Tudose, Ilinca, Ursu, Oleg, Vidović, Dušica, Waller, Anna, Westergaard, David, Yang, Jeremy J., Zahoránszky-Köhalmi, Gergely

“…In 2014, the Illuminating the Druggable Genome programme was launched to promote the exploration of currently understudied but potentially druggable proteins…”
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Exploiting Pharmacological Similarity to Identify Safety Concerns - Listen to What the Data Tells You by Muthas, Daniel, Boyer, Scott

“…Whilst most new drugs are designed to act on a single target or a small number of targets, many do show broad pharmacological activity. In some cases this can…”
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Evaluation of FOXO1 Target Engagement Using a Single-Cell Microfluidic Platform by Osman, Suhuur, Bendtsen, Claus, Peel, Samantha, Yrlid, Linda, Muthas, Daniel, Simpson, John, Willison, Keith R, Klug, David R

“…The cellular thermal shift assay (CETSA) has been used extensively since its introduction to study drug–target engagement within both live cells and cellular…”
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DrugPred: A Structure-Based Approach To Predict Protein Druggability Developed Using an Extensive Nonredundant Data Set by Krasowski, Agata, Muthas, Daniel, Sarkar, Aurijit, Schmitt, Stefan, Brenk, Ruth

“…Judging if a protein is able to bind orally available molecules with high affinity, i.e. if a protein is druggable, is an important step in target assessment…”
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BioSim—Exploiting pharmacological similarity in the context of drug safety by Muthas, Daniel, Boyer, Scott

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Type I interferon blockade with anifrolumab in patients with systemic lupus erythematosus modulates key immunopathological pathways in a gene expression and proteomic analysis of two phase 3 trials by Baker, Tina, Sharifian, Hoda, Newcombe, Paul J, Gavin, Patrick G, Lazarus, Mark N, Ramaswamy, Madhu, White, Wendy I, Ferrari, Nicola, Muthas, Daniel, Tummala, Raj, Morand, Eric F, Furie, Richard A, Vital, Edward M, Chamberlain, Chris, Platt, Adam, Al-Mossawi, Hussein, Brohawn, Philip Z, Csomor, Eszter

“…Anifrolumab is a type I interferon (IFN) receptor 1 (IFNAR1) blocking antibody approved for treating patients with systemic lupus erythematosus (SLE). Here, we…”
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Rare variant associations with plasma protein levels in the UK Biobank by Dhindsa, Ryan S., Burren, Oliver S., Sun, Benjamin B., Prins, Bram P., Matelska, Dorota, Wheeler, Eleanor, Mitchell, Jonathan, Oerton, Erin, Hristova, Ventzislava A., Smith, Katherine R., Carss, Keren, Wasilewski, Sebastian, Harper, Andrew R., Paul, Dirk S., Fabre, Margarete A., Runz, Heiko, Viollet, Coralie, Challis, Benjamin, Platt, Adam, Vitsios, Dimitrios, Ashley, Euan A., Whelan, Christopher D., Pangalos, Menelas N., Wang, Quanli, Petrovski, Slavé

“…Integrating human genomics and proteomics can help elucidate disease mechanisms, identify clinical biomarkers and discover drug targets 1 – 4 . Because…”
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