Search Results - "Muthalagu, Vetrichelvan"

Synthesis of Cyclobutane-Fused Tetracyclic Scaffolds via Visible-Light Photocatalysis for Building Molecular Complexity by Oderinde, Martins S, Mao, Edna, Ramirez, Antonio, Pawluczyk, Joseph, Jorge, Christine, Cornelius, Lyndon A. M, Kempson, James, Vetrichelvan, Muthalagu, Pitchai, Manivel, Gupta, Anuradha, Gupta, Arun Kumar, Meanwell, Nicholas A, Mathur, Arvind, Dhar, T. G. Murali

“…We describe the synthesis through visible-light photocatalysis of novel functionalized tetracyclic scaffolds that incorporate a fused…”
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Carbazole-Containing Conjugated Copolymers as Colorimetric/Fluorimetric Sensor for Iodide Anion by Vetrichelvan, Muthalagu, Nagarajan, Rajagopal, Valiyaveettil, Suresh

“…A series of conjugated poly(p-phenylene carbazole) copolymers, poly(N-hexyl-3,6-carbazole-alt-2,5-bisdodecyloxyphenylene) [P1],…”
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Cost-Effective and Scalable Synthesis of 4-Bromo-1,2-dimethyl-1H-imidazole: A Key Building Block for Bioactive Molecules by Vetrichelvan, Muthalagu, Lanke, Veeranjaneyulu, Chandu, Bellam, Mathur, Arvind, Gupta, Anuradha

“…Abstract A cost-effective, scalable, high-yielding, and commercially viable synthesis of 4-bromo-1,2-dimethyl-1H-imidazole (1), an important building block to…”
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Regioselective C3-Formylation of 2H-Indazoles Using Selectfluor under Microwave-Assisted Conditions by Pitchai, Manivel, Kaspady, Mahammed, Indasi, Gopikumar, Krishnan, Rajesh, Maheswarappa, Gururaju Sannakki, Vetrichelvan, Muthalagu, Mathur, Arvind, Gupta, Anuradha

“…Abstract An efficient microwave-assisted Selectfluor-mediated regioselective C3-formylation of 2H-indazoles bearing a variety of alkyl and aryl substituents…”
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Copper(II) Complexes of Schiff-Base and Reduced Schiff-Base Ligands: Influence of Weakly Coordinating Sulfonate Groups on the Structure and Oxidation of 3,5-DTBC by Sreenivasulu, Bellam, Vetrichelvan, Muthalagu, Zhao, Fei, Gao, Song, Vittal, Jagadese J.

“…The copper(II) complexes of the Schiff‐base ligands H2Sams and H2Saes and the reduced Schiff‐base ligands H2Sam and H2Sae formed between salicylaldehyde and…”
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Intramolecular Hydrogen-Bond-Assisted Planarization of Asymmetrically Functionalized Alternating Phenylene-Pyridinylene Copolymers by Vetrichelvan, Muthalagu, Valiyaveettil, Suresh

“…We report on the synthesis and characterization of a series of asymmetrically functionalized amphiphilic polymers with alternating π‐donor units (e.g.,…”
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3,11,19-Trithia[3.3.3]pyridinophane: Structural Diversity in Its Transition Metal Complexes by Vetrichelvan, Muthalagu, Lai, Yee-Hing, Mok, Kum Fun

“…The pyridine‐containing aza‐thia macrocycle 3,11,19‐trithia[3.3.3]pyridinophane (10) and its complexes with NiII, PdII, CuI, AgI and HgII were synthesised and…”
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Infinite Three-Dimensional Polymeric Metalloporphyrin Network via Six-Coordinate Zn(II) and Two Axial Oxygen Donors by Teo, Tang-Lin, Vetrichelvan, Muthalagu, Lai, Yee-Hing

“…An X-ray crystallographic study of zinc(II) 5,15-di-(2-methoxymethylphenyl)-porphyrin indicates that it forms a coordination polymer through ligation of the…”
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Synthesis, characterization and crystal structures of Cu(II) and Pd(II) complexes of the pentadentate mixed donor macrocycle, [17]aneNO2S2 by Vetrichelvan, Muthalagu, Lai, Yee-Hing, Mok, Kum Fun

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Identification of Monosaccharide Derivatives as Potent, Selective, and Orally Bioavailable Inhibitors of Human and Mouse Galectin‑3 by Liu, Chunjian, Jalagam, Prasada Rao, Feng, Jianxin, Wang, Wei, Raja, Thiruvenkadam, Sura, Mallikarjuna Reddy, Manepalli, Raju K. V. L. P., Aliphedi, Bheema Reddy, Medavarapu, Santosh, Nair, Satheesh K., Muthalagu, Vetrichelvan, Natesan, Ramesh, Gupta, Anuradha, Beno, Brett, Panda, Manoranjan, Ghosh, Kaushik, Shukla, Jinal Kaushikkumar, Sale, Harinath, Haldar, Priyanka, Kalidindi, Narasimharaju, Shah, Devang, Patel, Dipal, Mathur, Arvind, Ellsworth, Bruce A., Cheng, Dong, Regueiro-Ren, Alicia

“…Galectin-3 (Gal-3), a member of the β-galactoside-binding protein family, is implicated in a wide variety of human diseases. Identification of Gal-3 inhibitors…”
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Molecular mechanism of interspecies differences in the binding affinity of TD139 to Galectin-3 by Kumar, Amit, Paul, Marilyn, Panda, Manoranjan, Jayaram, Shruthi, Kalidindi, Narasimharaju, Sale, Harinath, Vetrichelvan, Muthalagu, Gupta, Anuradha, Mathur, Arvind, Beno, Brett, Regueiro-Ren, Alicia, Cheng, Dong, Ramarao, Manjunath, Ghosh, Kaushik

“…Abstract Galectin-3 (Gal-3), a β-galactoside-binding lectin, has been implicated in a plethora of pathological disorders including fibrosis, inflammation,…”
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Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4 by Priestley, E. Scott, Banville, Jacques, Deon, Daniel, Dubé, Laurence, Gagnon, Marc, Guy, Julia, Lapointe, Philippe, Lavallée, Jean-François, Martel, Alain, Plamondon, Serge, Rémillard, Roger, Ruediger, Edward, Tremblay, François, Posy, Shana L., Guarino, Victor R., Richter, Jeremy M., Li, Jianqing, Gupta, Anuradha, Vetrichelvan, Muthalagu, Balapragalathan, T. J., Mathur, Arvind, Hua, Ji, Callejo, Mario, Guay, Jocelyne, Sum, Chi Shing, Cvijic, Mary Ellen, Watson, Carol, Wong, Pancras, Yang, Jing, Bouvier, Michel, Gordon, David A., Wexler, Ruth R., Marinier, Anne

“…Protease-activated receptor 4 (PAR4) is a G-protein coupled receptor that is expressed on human platelets and activated by the coagulation enzyme thrombin…”
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Identification of benzothiazole derived monosaccharides as potent, selective, and orally bioavailable inhibitors of human and mouse galectin-3; a rare example of using a S···O binding interaction for drug design by Liu, Chunjian, Wang, Wei, Feng, Jianxin, Beno, Brett, Raja, Thiruvenkadam, Swidorski, Jacob, Manepalli, Raju K.V.L.P., Vetrichelvan, Muthalagu, Rao Jalagam, Prasada, Nair, Satheesh K., Gupta, Anuradha, Panda, Manoranjan, Ghosh, Kaushik, Kaushikkumar Shukla, Jinal, Sale, Harinath, Shah, Devang, Singh Gautam, Shashyendra, Patel, Dipal, Mathur, Arvind, Ellsworth, Bruce A., Cheng, Dong, Regueiro-Ren, Alicia

“…[Display omitted] As a result of our continued efforts to pursue Gal-3 inhibitors that could be used to fully evaluate the potential of Gal-3 as a therapeutic…”
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Intramolecular [2+2] Cycloaddition of N‐Allylcinnamamines and N‐Allylcinnamamides by Visible‐Light Photocatalysis by Oderinde, Martins S., Kempson, James, Smith, Daniel, Meanwell, Nicholas A., Mao, Edna, Pawluczyk, Joseph, Vetrichelvan, Muthalagu, Pitchai, Manivel, Karmakar, Ananta, Rampulla, Richard, Li, Jianqing, Murali Dhar, T. G., Mathur, Arvind

“…The visible light‐promoted intramolecular [2+2] cycloaddition of N‐allylcinnamamines and N‐allylcinnamamides in the presence of catalytic amounts of…”
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Chlorotrimethylsilane and Sodium Iodide: An Expedient Combination for the Chemo/Regioselective Dehalogenation of Benzothiazole and Thiazole Derivatives by Vetrichelvan, Muthalagu, Sankar, Ulaganathan, Bokkala, Vijayabhaskar, Akunuri, Arun, Ramesh, Natesan, Pitchai, Manivel, Mathur, Arvind, Gupta, Anuradha

“…The combination of chlorotrimethylsilane and NaI is disclosed as a reducing system for protodehalogenation of benzothiazole and thiazole derivatives;…”
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Development of a Rapid Scale-Up Synthesis of ( S )- N -(8-((2-Amino-2,4-dimethylpentyl)oxy)-5 H -chromeno[3,4- c ]pyridin-2-yl)acetamide, a Potent Adaptor-Associated Kinase 1 Inhibitor by Li, Jianqing, Smith, Daniel, Pawluczyk, Joseph, Krishnananthan, Subramaniam, Wang, Bei, Hou, Xiaoping, Zhao, Rulin, Kempson, James, Sun, Dawn, Yip, Shiuhang, Wu, Dauh-Rurng, Maddala, Nageswararao, Vetrichelvan, Muthalagu, Gupta, Anuradha, Macor, John E., Dzierba, Carolyn D., Mathur, Arvind

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Rationally Designed, Conformationally Constrained Inverse Agonists of RORγtIdentification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy by Marcoux, David, Duan, James J.-W, Shi, Qing, Cherney, Robert J, Srivastava, Anurag S, Cornelius, Lyndon, Batt, Douglas G, Liu, Qingjie, Beaudoin-Bertrand, Myra, Weigelt, Carolyn A, Khandelwal, Purnima, Vishwakrishnan, Sureshbabu, Selvakumar, Kumaravel, Karmakar, Ananta, Gupta, Arun Kumar, Basha, Mushkin, Ramlingam, Sridharan, Manjunath, Naveen, Vanteru, Sridhar, Karmakar, Sukhen, Maddala, Nageswara, Vetrichelvan, Muthalagu, Gupta, Anuradha, Rampulla, Richard A, Mathur, Arvind, Yip, Shiuhang, Li, Peng, Wu, Dauh-Rurng, Khan, Javed, Ruzanov, Max, Sack, John S, Wang, Jinhong, Yarde, Melissa, Cvijic, Mary Ellen, Li, Sha, Shuster, David J, Borowski, Virna, Xie, Jenny H, McIntyre, Kim W, Obermeier, Mary T, Fura, Aberra, Stefanski, Kevin, Cornelius, Georgia, Hynes, John, Tino, Joseph A, Macor, John E, Salter-Cid, Luisa, Denton, Rex, Zhao, Qihong, Carter, Percy H, Dhar, T. G. Murali

“…RORγt is an important nuclear receptor that regulates the production of several pro-inflammatory cytokines such as IL-17 and IL-22. As a result, RORγt has been…”
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Discovery of (S)‑1-((2′,6-Bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein‑2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain by Luo, Guanglin, Chen, Ling, Kostich, Walter A., Hamman, Brian, Allen, Jason, Easton, Amy, Bourin, Clotilde, Gulianello, Michael, Lippy, Jonathan, Nara, Susheel, Maishal, Tarun Kumar, Thiyagarajan, Kamalraj, Jalagam, Prasadrao, Pattipati, Sreenivasulu Naidu, Dandapani, Kumaran, Dokania, Manoj, Vattikundala, Pradeep, Sharma, Vivek, Elavazhagan, Saravanan, Verma, Manoj Kumar, Das, Manish Lal, Wagh, Santosh, Balakrishnan, Anand, Johnson, Benjamin M., Santone, Kenneth S., Thalody, George, Denton, Rex, Saminathan, Hariharan, Holenarsipur, Vinay K., Kumar, Anoop, Rao, Abhijith, Putlur, Siva Prasad, Sarvasiddhi, Sarat Kumar, Shankar, Ganesh, Louis, Justin V., Ramarao, Manjunath, Conway, Charles M., Li, Yu-Wen, Pieschl, Rick, Tian, Yuan, Hong, Yang, Ditta, Jonathan, Mathur, Arvind, Li, Jianqing, Smith, Daniel, Pawluczyk, Joseph, Sun, Dawn, Yip, Shiuhang, Wu, Dauh-Rurng, Vetrichelvan, Muthalagu, Gupta, Anuradha, Wilson, Alan, Gopinathan, Suma, Wason, Suman, Bristow, Linda, Albright, Charles F., Bronson, Joanne J., Macor, John E., Dzierba, Carolyn D.

“…Recent mouse knockout studies identified adapter protein-2 associated kinase 1 (AAK1) as a viable target for treating neuropathic pain. Potent small-molecule…”
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Synthesis of Functionalized 3‐Azabicyclo[3.2.0]Heptanes via Visible‐Light Energy‐Transfer Catalysis by Pitchai, Manivel, Kaspady, Mahammed, Kannan, Madhavan, Akunuri, Arunkumar, Indasi, Gopikumar, Pavan, Mysore S., Vetrichelvan, Muthalagu, Oderinde, Martins S., Kempson, James, Mathur, Arvind, Gupta, Anuradha

“…Functionalized cyclobutanes are three‐dimensional scaffolds widely found in natural products and bioactive molecules. Herein, we report a visible‐light‐induced…”
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Development of a Rapid Scale-Up Synthesis of (S)‑N‑(8-((2-Amino-2,4-dimethylpentyl)oxy)‑5H‑chromeno[3,4‑c]pyridin-2-yl)acetamide, a Potent Adaptor-Associated Kinase 1 Inhibitor by Li, Jianqing, Smith, Daniel, Pawluczyk, Joseph, Krishnananthan, Subramaniam, Wang, Bei, Hou, Xiaoping, Zhao, Rulin, Kempson, James, Sun, Dawn, Yip, Shiuhang, Wu, Dauh-Rurng, Maddala, Nageswararao, Vetrichelvan, Muthalagu, Gupta, Anuradha, Macor, John E, Dzierba, Carolyn D, Mathur, Arvind

“…(S)-N-(8-((2-Amino-2,4-dimethylpentyl)­oxy)-5H-chromeno­[3,4-c]­pyridin-2-yl)­acetamide (1) is a potent adaptor-associated kinase 1 inhibitor, which may have…”
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