Search Results - "Mutch, Nicola"

Fibrinolytic pathophysiologies: still the poor cousin of hemostasis? by Mutch, Nicola J.

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Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID‐19 by Whyte, Claire S., Morrow, Gael B., Mitchell, Joanne L., Chowdary, Pratima, Mutch, Nicola J.

“…The global pandemic of coronavirus disease 2019 (COVID‐19) is associated with the development of acute respiratory distress syndrome (ARDS), which requires…”
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Past, Present, and Future Perspectives of Plasminogen Activator Inhibitor 1 (PAI-1) by Morrow, Gael B, Mutch, Nicola J

“…Plasminogen activator inhibitor 1 (PAI-1), a SERPIN inhibitor, is primarily known for its regulation of fibrinolysis. However, it is now known that this…”
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uPA-mediated plasminogen activation is enhanced by polyphosphate by Whyte, Claire S, Mutch, Nicola J

“…Tissue plasminogen activator (tPA) and urokinase (uPA) differ in their modes of action. Efficient tPA-mediated plasminogen activation requires binding to…”
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Activation mechanism dependent surface exposure of cellular factor XIII on activated platelets and platelet microparticles by Somodi, Laura, Beke Debreceni, Ildikó, Kis, Gréta, Cozzolino, Marco, Kappelmayer, János, Antal, Miklós, Panyi, György, Bárdos, Helga, Mutch, Nicola J., Muszbek, László

“…Background Platelets contain a high amount of potentially active A subunit dimer of coagulation factor XIII (cellular FXIII; cFXIII). It is of cytoplasmic…”
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The fibrinolysis renaissance by Mutch, Nicola J, Medcalf, Robert L

“…Fibrinolysis is the system primarily responsible for removal of fibrin deposits and blood clots in the vasculature. The terminal enzyme in the pathway,…”
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Platelet-Mediated Modulation of Fibrinolysis by Whyte, Claire S, Mitchell, Joanne L, Mutch, Nicola J

“…Platelets are crucial to the hemostatic response. Their role in coagulation is well documented and they have been considered for some time to promote…”
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Functional plasminogen activator inhibitor 1 is retained on the activated platelet membrane following platelet activation by Morrow, Gael B, Whyte, Claire S, Mutch, Nicola J

“…Platelets harbor the primary reservoir of circulating plasminogen activator inhibitor 1 (PAI-1), but the reportedly low functional activity of this pool of…”
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Factor XIII-A: An Indispensable "Factor" in Haemostasis and Wound Healing by Alshehri, Fahad S M, Whyte, Claire S, Mutch, Nicola J

“…Factor XIII (FXIII) is a transglutaminase enzyme that catalyses the formation of ε-(γ-glutamyl)lysyl isopeptide bonds into protein substrates. The plasma form,…”
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Polyphosphate as a haemostatic modulator by Mutch, Nicola J

“…Platelets are small anuclear cells that play a central role in haemostasis. Platelets become activated in response to various stimuli triggering release of…”
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Trauma-induced coagulopathy by Moore, Ernest E., Moore, Hunter B., Kornblith, Lucy Z., Neal, Matthew D., Hoffman, Maureane, Mutch, Nicola J., Schöchl, Herbert, Hunt, Beverley J., Sauaia, Angela

“…Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic injury. Trauma-induced coagulopathy (TIC) describes abnormal…”
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The antifibrinolytic function of factor XIII is exclusively expressed through α2-antiplasmin cross-linking by Fraser, Steven R., Booth, Nuala A., Mutch, Nicola J.

“…Factor XIII (FXIII) generates fibrin-fibrin and fibrin-inhibitor cross-links. Our flow model, which is sensitive to cross-linking, was used to assess the…”
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A Serpin With a Finger in Many PAIs: PAI-1's Central Function in Thromboinflammation and Cardiovascular Disease by Morrow, Gael B, Whyte, Claire S, Mutch, Nicola J

“…Plasminogen activator inhibitor 1 (PAI-1) is a member of the serine protease inhibitor (serpin) superfamily. PAI-1 is the principal inhibitor of the…”
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Removing plasmin from the equation – Something to chew on by Morrow, Gael B., Mutch, Nicola J.

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Functional factor XIII-A is exposed on the stimulated platelet surface by Mitchell, Joanne L., Lionikiene, Ausra S., Fraser, Steven R., Whyte, Claire S., Booth, Nuala A., Mutch, Nicola J.

“…Factor XIII (FXIII) stabilizes thrombi against fibrinolysis by cross-linking α2-antiplasmin (α2AP) to fibrin. Cellular FXIII (FXIII-A) is abundant in…”
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The suboptimal fibrinolytic response in COVID‐19 is dictated by high PAI‐1 by Whyte, Claire S., Simpson, Megan, Morrow, Gael B., Wallace, Carol A., Mentzer, Alexander J., Knight, Julian C., Shapiro, Susan, Curry, Nicola, Bagot, Catherine N., Watson, Henry, Cooper, Jamie G., Mutch, Nicola J.

“…Severe COVID‐19 disease is associated with thrombotic complications and extensive fibrin deposition. This study investigates whether the hemostatic…”
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The Efficacy of Fibrinogen Concentrates in Relation to Cryoprecipitate in Restoring Clot Integrity and Stability against Lysis by Whyte, Claire S, Rastogi, Akriti, Ferguson, Ellis, Donnarumma, Michela, Mutch, Nicola J

“…Loss of fibrinogen is a feature of trauma-induced coagulopathy (TIC), and restoring this clotting factor is protective against hemorrhages. We compared the…”
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Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery by Kaira, Bubacarr G., Slater, Alexandre, McCrae, Keith R., Dreveny, Ingrid, Sumya, Ummay, Mutch, Nicola J., Searle, Mark, Emsley, Jonas

“…The contact system is composed of factor XII (FXII), prekallikrein (PK), and cofactor high-molecular-weight kininogen (HK). The globular C1q receptor (gC1qR)…”
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Atorvastatin-mediated inhibition of prenylation of Rab27b and Rap1a in platelets attenuates their prothrombotic capacity and modulates clot structure by Jalal, Mohammed M, Whyte, Claire S, Coxon, Fraser P, Mutch, Nicola J

“…Statins inhibit the mevalonate pathway by impairing protein prenylation via depletion of lipid geranylgeranyl diphosphate (GGPP). Rab27b and Rap1a are small…”
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Acute obstetric coagulopathy during postpartum hemorrhage is caused by hyperfibrinolysis and dysfibrinogenemia: an observational cohort study by de Lloyd, Lucy, Jenkins, Peter V., Bell, Sarah F., Mutch, Nicola J., Martins Pereira, Julia Freyer, Badenes, Pilar M., James, Donna, Ridgeway, Anouk, Cohen, Leon, Roberts, Thomas, Field, Victoria, Collis, Rachel E., Collins, Peter W.

“…Postpartum hemorrhage (PPH) may be exacerbated by hemostatic impairment. Information about PPH-associated coagulopathy is limited, often resulting in treatment…”
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