Search Results - "Mutation research"

Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer by Caliri, Andrew W., Tommasi, Stella, Besaratinia, Ahmad

“…[Display omitted] •Oxidative stress is a key contributor to both cancer and inflammatory diseases.•Smoking-induced ROS can damage macromolecular…”
Get full text

Ionizing radiation biomarkers in epidemiological studies – An update by Hall, Janet, Jeggo, Penny A., West, Catharine, Gomolka, Maria, Quintens, Roel, Badie, Christophe, Laurent, Olivier, Aerts, An, Anastasov, Nataša, Azimzadeh, Omid, Azizova, Tamara, Baatout, Sarah, Baselet, Bjorn, Benotmane, Mohammed A., Blanchardon, Eric, Guéguen, Yann, Haghdoost, Siamak, Harms-Ringhdahl, Mats, Hess, Julia, Kreuzer, Michaela, Laurier, Dominique, Macaeva, Ellina, Manning, Grainne, Pernot, Eileen, Ravanat, Jean-Luc, Sabatier, Laure, Tack, Karine, Tapio, Soile, Zitzelsberger, Horst, Cardis, Elisabeth

“…Recent epidemiology studies highlighted the detrimental health effects of exposure to low dose and low dose rate ionizing radiation (IR): nuclear industry…”
Get full text

Exposure to glyphosate-based herbicides and risk for non-Hodgkin lymphoma: A meta-analysis and supporting evidence by Zhang, Luoping, Rana, Iemaan, Shaffer, Rachel M., Taioli, Emanuela, Sheppard, Lianne

“…Glyphosate is the most widely used broad-spectrum systemic herbicide in the world. Recent evaluations of the carcinogenic potential of glyphosate-based…”
Get full text

Histone methylation and the DNA damage response by Gong, Fade, Miller, Kyle M.

“…Preserving genome function and stability are paramount for ensuring cellular homeostasis, an imbalance in which can promote diseases including cancer. In the…”
Get full text

Application of the comet assay in human biomonitoring: An hCOMET perspective by Azqueta, Amaya, Ladeira, Carina, Giovannelli, Lisa, Boutet-Robinet, Elisa, Bonassi, Stefano, Neri, Monica, Gajski, Goran, Duthie, Susan, Del Bo’, Cristian, Riso, Patrizia, Koppen, Gudrun, Basaran, Nursen, Collins, Andrew, Møller, Peter

“…The comet assay is a well-accepted biomonitoring tool to examine the effect of dietary, lifestyle, environmental and occupational exposure on levels of DNA…”
Get full text

Micronuclei as biomarkers of DNA damage, aneuploidy, inducers of chromosomal hypermutation and as sources of pro-inflammatory DNA in humans by Fenech, Michael, Knasmueller, Siegfried, Bolognesi, Claudia, Holland, Nina, Bonassi, Stefano, Kirsch-Volders, Micheline

“…•Micronuclei (MNi) are a biomarker of chromosomal damage and instability in humans.•Causes and consequences of MNi formation can be elucidated using molecular…”
Get full text

Aflatoxin B1 metabolism: Regulation by phase I and II metabolizing enzymes and chemoprotective agents by Deng, Jiang, Zhao, Ling, Zhang, Ni-Ya, Karrow, Niel Alexander, Krumm, Christopher Steven, Qi, De-Sheng, Sun, Lv-Hui

“…Aflatoxin B1 (AFB1) widely contaminates staple food and feed crops and is well-known as the most potent natural hepatocarcinogen in humans and domesticated…”
Get full text

In vitro cell migration and invasion assays by Kramer, Nina, Walzl, Angelika, Unger, Christine, Rosner, Margit, Krupitza, Georg, Hengstschläger, Markus, Dolznig, Helmut

“…Determining the migratory and invasive capacity of tumor and stromal cells and clarifying the underlying mechanisms is most relevant for novel strategies in…”
Get full text

Mechanisms of oocyte aneuploidy associated with advanced maternal age by Mikwar, Myy, MacFarlane, Amanda J., Marchetti, Francesco

“…•Advanced maternal age increases chromosome segregation errors during meiosis.•Recombination failure and cohesin degradation promote chromosome…”
Get full text

Orofacial clefts embryology, classification, epidemiology, and genetics by Nasreddine, Ghenwa, El Hajj, Joelle, Ghassibe-Sabbagh, Michella

“…Orofacial clefts (OFCs) rank as the second most common congenital birth defect in the United States after Down syndrome and are the most common head and neck…”
Get full text

Initial steps of metastasis: Cell invasion and endothelial transmigration by van Zijl, Franziska, Krupitza, Georg, Mikulits, Wolfgang

“…Metastasis is the leading cause of cancer mortality. The metastatic cascade represents a multi-step process which includes local tumor cell invasion, entry…”
Get full text

DNA mismatch repair and its many roles in eukaryotic cells by Liu, Dekang, Keijzers, Guido, Rasmussen, Lene Juel

“…DNA mismatch repair (MMR) is an important DNA repair pathway that plays critical roles in DNA replication fidelity, mutation avoidance and genome stability,…”
Get full text

TERT promoter mutations in telomere biology by Heidenreich, Barbara, Kumar, Rajiv

“…Telomere repeats at chromosomal ends, critical to genome integrity, are maintained through an elaborate network of proteins and pathways. Shelterin complex…”
Get full text

Molecular mechanisms underlying human papillomavirus E6 and E7 oncoprotein-induced cell transformation by Mittal, Suruchi, Banks, Lawrence

“…Human papillomaviruses (HPVs) are the causative agents of 5% of all human cancers, with cervical cancer being the most important. Two viral oncoproteins, E6…”
Get full text

Human papillomavirus molecular biology by Harden, Mallory E., Munger, Karl

“…Human papillomaviruses are small DNA viruses with a tropism for squamous epithelia. A unique aspect of human papillomavirus molecular biology involves…”
Get full text

Oxidatively induced DNA damage and its repair in cancer by Dizdaroglu, Miral

“…Oxidatively induced DNA damage is caused in living organisms by endogenous and exogenous reactive species. DNA lesions resulting from this type of damage are…”
Get full text

The molecular origins and pathophysiological consequences of micronuclei: New insights into an age-old problem by Guo, Xihan, Ni, Juan, Liang, Ziqing, Xue, Jinglun, Fenech, Michael F., Wang, Xu

“…[Display omitted] Micronuclei (MN), the small nucleus-like bodies separated from the primary nucleus, can exist in cells with numerical and/or structural…”
Get full text

Fate of micronuclei and micronucleated cells by Hintzsche, Henning, Hemmann, Ulrike, Poth, Albrecht, Utesch, Dietmar, Lott, Jasmin, Stopper, Helga

“…The present review describes available evidence about the fate of micronuclei and micronucleated cells. Micronuclei are small, extranuclear chromatin bodies…”
Get full text

Potentiation of hydrogen peroxide toxicity: From catalase inhibition to stable DNA-iron complexes by Mahaseth, Tulip, Kuzminov, Andrei

“…Hydrogen peroxide (H2O2) is unique among general toxins, because it is stable in abiotic environments at ambient temperature and neutral pH, yet rapidly kills…”
Get full text

Biological activity of piceatannol: Leaving the shadow of resveratrol by Piotrowska, Hanna, Kucinska, Malgorzata, Murias, Marek

“…Resveratrol (3,4′,5- trans-trihydroxystilbene), a naturally occurring stilbene, is considered to have a number of beneficial effects, including anticancer,…”
Get full text