Serum N-Terminal-pro-B-Type Natriuretic Peptide (NT-pro-BNP) Levels in Hyperthyroidism and Hypothyroidism

Serum N-Terminal-pro-B-Type Natriuretic Peptide (NT-pro-BNP) Levels in Hyperthyroidism and Hypothyroidism

Natriuretic peptides represent a novel diagnostic tool in the assessment of heart failure. N-terminal-pro-B-type natriuretic peptide (NT-proBNP), a member of the natriuretic peptid family, is produced and released from cardiac ventricles. Changes in cardiac functions are observed in thyroid dysfunct...

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Bibliographic Details
Published in:Endocrine research Vol. 32; no. 1-2; pp. 1 - 8
Main Authors: Özmen, Bilgin, Özmen, Dilek, Parildar, Zuhal, Mutaf, I l, Bayindir, Oya
Format: Journal Article
Language:English
Published: England Informa UK Ltd 01-01-2007
Taylor & Francis
Subjects:
Adult
Aged
Case-Control Studies
Female
Heart Rate - physiology
Humans
Hyperthyroidism - blood
Hyperthyroidism - physiopathology
Hypothyroidism - blood
Hypothyroidism - physiopathology
Male
Middle Aged
Natriuretic Peptide, Brain - blood
Peptide Fragments - blood
Thyroid Hormones - blood
Thyrotropin - blood
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Summary:Natriuretic peptides represent a novel diagnostic tool in the assessment of heart failure. N-terminal-pro-B-type natriuretic peptide (NT-proBNP), a member of the natriuretic peptid family, is produced and released from cardiac ventricles. Changes in cardiac functions are observed in thyroid dysfunctions. The aim of this study was to assess the changes in serum NT-proBNP levels and to evaluate impact of thyroid hormones on serum NT-proBNP in patients with hyperthyroidism and hypothyroidism. Serum NT-proBNP levels were measured in 21 patients with hyperthyroidism and in 24 patients with hypothyroidism and compared with 20 healthy control subjects. Patients without cardiac disease were included into the study as well. Serum NT-proBNP levels were measured by electrochemiluminescence immunoassay. Serum NT-proBNP levels were higher in hyperthyroid patients than in hypothyroid patients and in control subjects, with mean values of 239.03 ± 47.33, 45.97 ± 13.48, 55.57 ± 13.01 pg ml, respectively (p < 0.0001). Serum NT-proBNP and thyroid hormones were correlated in all patients. Moreover, there was a significant positive correlation between serum NT-proBNP and serum free T4 (FT4) levels (r = 0,549, p = 0.012) in hyperthyroidic patients. Multiple regression analyses demonstrated that increasing FT4 was independently associated with a high serum NT-proBNP levels, whereas heart rate was not in hyperthyroid patients. Serum NT-proBNP levels are higher in the hyperthyroid state as compared with the hypothyroid and euthyroid state. Thyroid dysfunction affects serum NT-proBNP levels, possibly influencing the secretion of the peptide. Therefore, thyroid function has to be considered when evaluating high serum NT-proBNP levels in patients without cardiac dysfunction.
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ISSN:0743-5800
1532-4206
DOI:10.1080/07435800701670047