Lipoic acid prevents hepatic and intestinal damage induced by obstruction of the common bile duct in rats

Cholestatic liver diseases are characterized by impaired hepatocellular secretion of bile, resulting in intracellular accumulation of bile acids which result in a shift in the oxidant/prooxidant balance in favor of increased free radical activity and injury of different tissues including liver and i...

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Bibliographic Details
Published in:	European review for medical and pharmacological sciences Vol. 17; no. 10; p. 1305
Main Authors:	Somi, M H, Kalageychi, H, Hajipour, B, Musavi, G, Khodadadi, A, Shokri, N, Hashemi, R, Bagheri, I, Mutab Laleh, F
Format:	Journal Article
Language:	English
Published:	Italy 01-05-2013
Subjects:	Animals Antioxidants - therapeutic use Cholestasis - drug therapy Cholestasis - pathology Common Bile Duct Diseases - drug therapy Common Bile Duct Diseases - pathology Glutathione Peroxidase - metabolism Intestines - pathology Lipid Peroxidation - drug effects Liver - pathology Male Rats Rats, Wistar Superoxide Dismutase - metabolism Thioctic Acid - therapeutic use
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Summary:	Cholestatic liver diseases are characterized by impaired hepatocellular secretion of bile, resulting in intracellular accumulation of bile acids which result in a shift in the oxidant/prooxidant balance in favor of increased free radical activity and injury of different tissues including liver and intestine. The aim of this research was to study protective effect of lipoic acid (LA) as a potent antioxidant in cholestsis induced hepatic and intestinal injury in rats. Forty five adult male Wistar rats were randomly assigned to four groups each containing fifteen rats as follows: sham operation (SO) (control), bile duct ligating (BDL), and BDL+LA (25 mg/kg). After fourteen days hepatic and intestinal tissue sampled and blood serum sampled for pathologic and biochemical studies. Levels of SOD and GPx antioxidant enzymes were higher in BDL+LA group comparing to BDL group, levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and γ-glutamyltranspeptidase (GGT), and pathologic scores in liver and intestine were lower in BDL+LA group comparing to BDL group significantly, but there is no significant difference in concentrations of total bilirubin between groups. Our results showed the protective potential of LA with liver and intestine damage. Despite improvements in operative technique and the development of potent, broad-spectrum antibiotics, biliary tract surgery in patients with obstructive jaundice is still associated with high morbidity and mortality rates In summary, our results show that BDL induced hepatic and intestinal injury were significantly attenuated by LA administration and the administration of LA could effectively diminish this damage.
ISSN:	1128-3602