Search Results - "Muta, Kyotaka"

Deep learning-based image-analysis algorithm for classification and quantification of multiple histopathological lesions in rat liver by Shimazaki, Taishi, Deshpande, Ameya, Hajra, Anindya, Thomas, Tijo, Muta, Kyotaka, Yamada, Naohito, Yasui, Yuzo, Shoda, Toshiyuki

“…Artificial intelligence (AI)-based image analysis is increasingly being used for preclinical safety-assessment studies in the pharmaceutical industry. In this…”
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A proposed mechanism for the adverse effects of acebutolol: CES2 and CYP2C19-mediated metabolism and antinuclear antibody production by Muta, Kyotaka, Fukami, Tatsuki, Nakajima, Miki

“…[Display omitted] Acebutolol, a β-adrenergic receptor-blocker, occasionally causes drug-induced lupus erythematosus (DILE). Acebutolol is mainly metabolized to…”
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Lack of toxicological influences by microsampling (50 µL) from jugular vein of rats in a collaborative 28-day study by Yokoyama, Hideaki, Hattori, Norimichi, Ohtsuka, Hirohiko, Murata, Eiji, Kobayashi, Akio, Muta, Kyotaka, Takumi, Asuka, Kitaura, Harumi, Jinno, Fumihiro, Iwai, Atsushi, Nakai, Keiko, Mori, Kanae, Saito, Kosuke, Saito, Yoshiro

“…Due to finalization of the ICH S3A Q&A focusing on microsampling, application of microsampling technique to regular non-clinical animal studies is expected for…”
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Ether-phosphatidylcholine characterized by consolidated plasma and liver lipidomics is a predictive biomarker for valproic acid-induced hepatic steatosis by Goda, Keisuke, Saito, Kosuke, Muta, Kyotaka, Kobayashi, Akio, Saito, Yoshiro, Sugai, Shoichiro

“…Valproic acid (VPA) is known to induce hepatic steatosis due to mitochondrial toxicity in rodents and humans. In the present study, we administered VPA to SD…”
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Selenium and Glutathione-Depleted Rats as a Sensitive Animal Model to Predict Drug-Induced Liver Injury in Humans by Goda, Keisuke, Muta, Kyotaka, Yasui, Yuzo, Oshida, Shin-Ichi, Kitatani, Kanae, Takekoshi, Susumu

“…Drug-induced liver injury (DILI) is one of the most serious and frequent drug-related adverse events in humans. Selenium (Se) and glutathione (GSH) have a…”
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High fructose diet feeding accelerates diabetic nephropathy in Spontaneously Diabetic Torii (SDT) rats by Toyoda, Kaoru, Suzuki, Yusuke, Muta, Kyotaka, Masuyama, Taku, Kakimoto, Kochi, Kobayashi, Akio, Shoda, Toshiyuki, Sugai, Shoichiro

“…Diabetic nephropathy (DN) is one of the complications of diabetes and is now the most common cause of end-stage renal disease. Fructose is a simple…”
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N-Glycosylation during translation is essential for human arylacetamide deacetylase enzyme activity by Muta, Kyotaka, Fukami, Tatsuki, Nakajima, Miki, Yokoi, Tsuyoshi

“…Human arylacetamide deacetylase (AADAC) can hydrolyze clinical drugs such as flutamide, phenacetin, and rifamycins. AADAC is a glycoprotein, but the role of…”
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Phosphatidylcholine (18:0/20:4), a potential biomarker to predict ethionamide‐induced hepatic steatosis in rats by Muta, Kyotaka, Saito, Kosuke, Kemmochi, Yusuke, Masuyama, Taku, Kobayashi, Akio, Saito, Yoshiro, Sugai, Shoichiro

“…Ethionamide (ETH), a second‐line drug for multidrug‐resistant tuberculosis, is known to cause hepatic steatosis in rats and humans. To investigate predictive…”
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Deep learning-based image-analysis algorithm for classification and quantification of multiple histopathological lesions in rat liver by SHIMAZAKI, Taishi, DESHPANDE, Ameya, HAJRA, Anindya, THOMAS, Tijo, MUTA, Kyotaka, YAMADA, Naohito, YASUI, Yuzo, SHODA, Toshiyuki

“…Artificial intelligence (AI)-based image analysis is increasingly being used for preclinical safety-assessment studies in the pharmaceutical industry. In this…”
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