Clustering of hepatitis C infection among family members in Aden, Yemen

Clustering of hepatitis C infection among family members in Aden, Yemen

BackgroundHepatitis C infection is a common cause of liver diseases such as cirrhosis and liver carcinoma. This study aims to determine the clustering of HCV infection among family members of HCV-positive patients (index cases) and the association between internal and external risk factors and HCV i...

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Bibliographic Details
Published in:Egyptian Liver Journal Vol. 14; no. 1; pp. 85 - 7
Main Authors: Gubran, Ali N.M, Al-Barq, Ali Mohsen Mohammed, Hashem, Mohammed Abdulbaset Mohammed, Saleh, Noura Ramzy Mohammed, Saleh, Abdulsalam Abdullah Mohammed, Mohammed, Shaima Rashad Saleh Ali, Bn Zead, Wala Salem Saleh Salem, Muswat, Fatima Luai Ali Saeed, Bahumaish, Arwa Khaled Ali Mohammed, Al-Saadi, Yousif Fahmi Qasim
Format: Journal Article
Language:English
Published: Menoufiya Springer Nature B.V 18-11-2024
SpringerOpen
Subjects:
Acupuncture
Aden
Age
Blood transfusions
Clustering
Families & family life
Family members
Females
Hepatitis C
Hepatitis C infection
Infections
Liver cirrhosis
Males
Marital status
Patients
Risk factors
Tattoos
Toothbrushes
Brazil
Italy
Pakistan
Iran
Egypt
Yemen
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Summary:BackgroundHepatitis C infection is a common cause of liver diseases such as cirrhosis and liver carcinoma. This study aims to determine the clustering of HCV infection among family members of HCV-positive patients (index cases) and the association between internal and external risk factors and HCV infection among these family members.MethodsThis cross-sectional study was conducted during a period from January to June 2024. One hundred and seventeen family members belonging to 26 index cases were enrolled in this study. Blood samples were collected from all family members, and then sera were separated and tested for anti-HCV antibodies by using a commercially available Cobas technique based on ECLIA.ResultsAmong 117 family members, the majority 55.6% were females. The clustering of HCV infection among family members was 7.7%. The highest rates were 9.6% among males and 11.8% among members who were in close contact with female-positive cases, 12.8% in the age group 20–29 years, and 27.3% among brothers, but there were no HCV-positive cases detected among fathers, daughters, and husbands. There was a significant association between HCV infection and some behaviors of family members such as sharing the same sleeping places, nail clippers, and towels with index cases and exposure to cupping (p = 0.0001, 0.002, 0.017, and 0.050), respectively.ConclusionThe HCV infection among family members in Aden, Yemen, was low in comparison with most studies globally. The highest rates were found among males, those in contact with female index cases, in the age group 20–29 years, and brothers as relatives, but there were no positive cases among fathers, husbands, daughters, and other relatives.
ISSN:2090-6218
2090-6226
DOI:10.1186/s43066-024-00390-z