Transcription factor 7-like 2 (TCF7L2) rs12255372 variant and the risk of type 2 diabetes mellitus among the Kurdish population in Erbil, Iraq

Transcription factor 7-like 2 (TCF7L2) rs12255372 variant and the risk of type 2 diabetes mellitus among the Kurdish population in Erbil, Iraq

Background The genetic predispositions related to type 2 diabetes (T 2 D) in the Middle East are poorly understood. One of the most common single-nucleotide polymorphisms (SNP) located in the transcription factor 7-like-2 ( TCF7L2 ) gene is rs12255372 variant which elucidated a significant role in d...

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Bibliographic Details
Published in:International journal of diabetes in developing countries Vol. 41; no. 3; pp. 441 - 446
Main Authors: Younus, Delan Ameen, Mustafa, Suhad Asaad, Abdullah, Lade Yasin, Mustafa, Muzheir Salem
Format: Journal Article
Language:English
Published: New Delhi Springer India 01-07-2021
Springer Nature B.V
Subjects:
Alleles
Diabetes
Diabetes mellitus (non-insulin dependent)
Family Medicine
General Practice
Genotyping
Health Administration
Medicine
Medicine & Public Health
Original Article
Population
Population studies
Risk factors
Single-nucleotide polymorphism
Transcription factors
Iraq
Tetra ARMS-PCR
Single-nucleotide polymorphism
Type 2 diabetes (T
D
rs12255372 G > T
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Summary:Background The genetic predispositions related to type 2 diabetes (T 2 D) in the Middle East are poorly understood. One of the most common single-nucleotide polymorphisms (SNP) located in the transcription factor 7-like-2 ( TCF7L2 ) gene is rs12255372 variant which elucidated a significant role in developing T 2 D, especially in the European population. The current study is the first to have examined the association between TCF7L2 rs12255372 variant and T 2 D among the Iraqi Kurdish population from Iraq. Methods Three hundred participants were enrolled in this study: 150 were type 2 diabetic patients and 150 were normoglycemic controls. For genotyping rs12255372 (G > T) variant, Tetra ARMS-PCR was used which is high-throughput, cost and time effective technique. Results The genotypic frequencies in the additive genetic model (co-dominant) for GG, GT, and TT were 62.7%, 24%, and 13.3% in the normoglycemic controls, respectively, and for the diabetic patients were 50.7%, 20%, and 29.3%, respectively. The TT genotype was found considerably higher in cases when matched to the normoglycemic controls in both co-dominant and recessive models with OR (95% CI) = 2.64 (1.29–5.41) ( p value  = 0.006) and OR (95% CI) = 1.531 (1.232–1.902) ( p value  = 0.001), respectively. These frequencies indicated that the carriers of the TT genotype were more susceptible to T 2 D compared to other genotypes. The T allele showed a high significant frequency in T 2 D patients compared to the normoglycemic controls with OR (95% CI) = 1.38 (1.16–1.59) ( p value  = 0.000). Conclusion Our results suggest rs12255372 T allele as a putative risk factor that increases the susceptibility of T 2 D among the Iraqi Kurdish population.
ISSN:0973-3930
1998-3832
DOI:10.1007/s13410-021-00921-z