Epitope-Based Peptide Vaccine against Glycoprotein G of Nipah Henipavirus Using Immunoinformatics Approaches

Epitope-Based Peptide Vaccine against Glycoprotein G of Nipah Henipavirus Using Immunoinformatics Approaches

Background. Nipah belongs to the genus Henipavirus and the Paramyxoviridae family. It is an endemic most commonly found at South Asia and has first emerged in Malaysia in 1998. Bats are found to be the main reservoir for this virus, causing disease in both humans and animals. The last outbreak has o...

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Bibliographic Details
Published in:Journal of immunology research Vol. 2020; no. 2020; pp. 1 - 12
Main Authors: Elnnewery, Mihad E., Yousif, Einas M., Elfadol, Nafisa M., Abdalla, Alaa I., Mahmoud, Eiman, Yagaub, Ahmed A., Ahmed, Yassir A., Hassan, Mohamed A., Abdelrhman, Fatima A., Mohammed, Rawan A., Osman, Isam-Aldin A., Elmansi, Hashim E., Osman, Hind K., Mustafa, Mujahed I., Wagiealla Shantier, Shaza, Mohammed, Arwa A., Mustafa, Marwa M.
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Publishing Corporation 2020
Hindawi
Hindawi Limited
Subjects:
Affinity
Amino acids
Antigens, Viral - genetics
Antigens, Viral - metabolism
Antiviral agents
Asia, Southeastern - epidemiology
Asymptomatic infection
Computational Biology
Encephalitis
Endemic Diseases
Epitope Mapping
Epitopes
Epitopes - genetics
Epitopes - immunology
Epitopes - metabolism
Glycoprotein G
Glycoproteins
Glycoside Hydrolases - genetics
Glycoside Hydrolases - metabolism
Henipavirus
Henipavirus Infections - epidemiology
Henipavirus Infections - immunology
HLA Antigens - metabolism
Humans
Illnesses
Immunology
Infections
Lymphocytes
Lymphocytes T
Major histocompatibility complex
Malaysia - epidemiology
Molecular Docking Simulation
Neural networks
Nipah Virus - physiology
Pathogenicity
Pathogens
Peptides
Population
Population genetics
Protein Binding
Proteins
Respiratory diseases
Respiratory Tract Infections
Vaccination
Vaccines
Vaccines, Subunit - immunology
Viral Vaccines - immunology
Viruses
Asia, Southeastern
Malaysia
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Summary:Background. Nipah belongs to the genus Henipavirus and the Paramyxoviridae family. It is an endemic most commonly found at South Asia and has first emerged in Malaysia in 1998. Bats are found to be the main reservoir for this virus, causing disease in both humans and animals. The last outbreak has occurred in May 2018 in Kerala. It is characterized by high pathogenicity and fatality rates which varies from 40% to 70% depending on the severity of the disease and on the availability of adequate healthcare facilities. Currently, there are no antiviral drugs available for NiV disease and the treatment is just supportive. Clinical presentations for this virus range from asymptomatic infection to fatal encephalitis. Objective. This study is aimed at predicting an effective epitope-based vaccine against glycoprotein G of Nipah henipavirus, using immunoinformatics approaches. Methods and Materials. Glycoprotein G of the Nipah virus sequence was retrieved from NCBI. Different prediction tools were used to analyze the epitopes, namely, BepiPred-2.0: Sequential B Cell Epitope Predictor for B cell and T cell MHC classes II and I. Then, the proposed peptides were docked using Autodock 4.0 software program. Results and Conclusions. The two peptides TVYHCSAVY and FLIDRINWI have showed a very strong binding affinity to MHC class I and MHC class II alleles. Furthermore, considering the conservancy, the affinity, and the population coverage, the peptide FLIDRINWIT is highly suitable to be utilized to formulate a new vaccine against glycoprotein G of Nipah henipavirus. An in vivo study for the proposed peptides is also highly recommended.
Bibliography:ObjectType-Article-1
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Academic Editor: Darren R. Flower
ISSN:2314-8861
2314-7156
DOI:10.1155/2020/2567957