Search Results - "Mussolin, Benedetta"

Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer by Barault, Ludovic, Amatu, Alessio, Siravegna, Giulia, Ponzetti, Agostino, Moran, Sebastian, Cassingena, Andrea, Mussolin, Benedetta, Falcomatà, Chiara, Binder, Alexandra M, Cristiano, Carmen, Oddo, Daniele, Guarrera, Simonetta, Cancelliere, Carlotta, Bustreo, Sara, Bencardino, Katia, Maden, Sean, Vanzati, Alice, Zavattari, Patrizia, Matullo, Giuseppe, Truini, Mauro, Grady, William M, Racca, Patrizia, Michels, Karin B, Siena, Salvatore, Esteller, Manel, Bardelli, Alberto, Sartore-Bianchi, Andrea, Di Nicolantonio, Federica

“…Mutations in cell-free circulating DNA (cfDNA) have been studied for tracking disease relapse in colorectal cancer (CRC). This approach requires personalised…”
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Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer by Van Emburgh, Beth O., Arena, Sabrina, Siravegna, Giulia, Lazzari, Luca, Crisafulli, Giovanni, Corti, Giorgio, Mussolin, Benedetta, Baldi, Federica, Buscarino, Michela, Bartolini, Alice, Valtorta, Emanuele, Vidal, Joana, Bellosillo, Beatriz, Germano, Giovanni, Pietrantonio, Filippo, Ponzetti, Agostino, Albanell, Joan, Siena, Salvatore, Sartore-Bianchi, Andrea, Di Nicolantonio, Federica, Montagut, Clara, Bardelli, Alberto

“…Blockade of the epidermal growth factor receptor (EGFR) with the monoclonal antibodies cetuximab or panitumumab is effective in a subset of colorectal cancers…”
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Acquired Resistance to the TRK Inhibitor Entrectinib in Colorectal Cancer by Russo, Mariangela, Misale, Sandra, Wei, Ge, Siravegna, Giulia, Crisafulli, Giovanni, Lazzari, Luca, Corti, Giorgio, Rospo, Giuseppe, Novara, Luca, Mussolin, Benedetta, Bartolini, Alice, Cam, Nicholas, Patel, Roopal, Yan, Shunqi, Shoemaker, Robert, Wild, Robert, Di Nicolantonio, Federica, Bianchi, Andrea Sartore, Li, Gang, Siena, Salvatore, Bardelli, Alberto

“…Entrectinib is a first-in-class pan-TRK kinase inhibitor currently undergoing clinical testing in colorectal cancer and other tumor types. A patient with…”
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Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer by Russo, Mariangela, Siravegna, Giulia, Blaszkowsky, Lawrence S, Corti, Giorgio, Crisafulli, Giovanni, Ahronian, Leanne G, Mussolin, Benedetta, Kwak, Eunice L, Buscarino, Michela, Lazzari, Luca, Valtorta, Emanuele, Truini, Mauro, Jessop, Nicholas A, Robinson, Hayley E, Hong, Theodore S, Mino-Kenudson, Mari, Di Nicolantonio, Federica, Thabet, Ashraf, Sartore-Bianchi, Andrea, Siena, Salvatore, Iafrate, A John, Bardelli, Alberto, Corcoran, Ryan B

“…How genomic heterogeneity associated with acquired resistance to targeted agents affects response to subsequent therapy is unknown. We studied EGFR blockade in…”
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MM-151 overcomes acquired resistance to cetuximab and panitumumab in colorectal cancers harboring EGFR extracellular domain mutations by Arena, Sabrina, Siravegna, Giulia, Mussolin, Benedetta, Kearns, Jeffrey D, Wolf, Beni B, Misale, Sandra, Lazzari, Luca, Bertotti, Andrea, Trusolino, Livio, Adjei, Alex A, Montagut, Clara, Di Nicolantonio, Federica, Nering, Rachel, Bardelli, Alberto

“…The anti-epidermal growth factor receptor (EGFR) antibodies cetuximab and panitumumab are used to treat RAS wild-type colorectal cancers (CRCs), but their…”
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Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies by Russo, Mariangela, Lamba, Simona, Lorenzato, Annalisa, Sogari, Alberto, Corti, Giorgio, Rospo, Giuseppe, Mussolin, Benedetta, Montone, Monica, Lazzari, Luca, Arena, Sabrina, Oddo, Daniele, Linnebacher, Michael, Sartore-Bianchi, Andrea, Pietrantonio, Filippo, Siena, Salvatore, Di Nicolantonio, Federica, Bardelli, Alberto

“…Attempts at eradicating metastatic cancers with targeted therapies are limited by the emergence of resistant subclones bearing heterogeneous (epi)genetic…”
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Emergence of MET hyper-amplification at progression to MET and BRAF inhibition in colorectal cancer by Oddo, Daniele, Siravegna, Giulia, Gloghini, Annunziata, Vernieri, Claudio, Mussolin, Benedetta, Morano, Federica, Crisafulli, Giovanni, Berenato, Rosa, Corti, Giorgio, Volpi, Chiara Costanza, Buscarino, Michela, Niger, Monica, Dunne, Philip D, Rospo, Giuseppe, Valtorta, Emanuele, Bartolini, Alice, Fucà, Giovanni, Lamba, Simona, Martinetti, Antonia, Di Bartolomeo, Maria, de Braud, Filippo, Bardelli, Alberto, Pietrantonio, Filippo, Di Nicolantonio, Federica

“…Background: Combined MET and BRAF inhibition showed clinical benefit in a patient with rectal cancer carrying BRAF V600E and MET amplification. However after 4…”
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Case Report: MAP2K1 K57N mutation is associated with primary resistance to anti-EGFR monoclonal antibodies in metastatic colorectal cancer by Mauri, Gianluca, Patelli, Giorgio, Gori, Viviana, Lauricella, Calogero, Mussolin, Benedetta, Amatu, Alessio, Bencardino, Katia, Tosi, Federica, Bonazzina, Erica, Bonoldi, Emanuela, Bardelli, Alberto, Siena, Salvatore, Sartore-Bianchi, Andrea

“…We aim to identify the prevalence and the role of the mutation in predicting resistance to anti-EGFR agents in metastatic colorectal cancer (mCRC) patients. We…”
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Corrigendum: Case report: MAP2K1 K57N mutation is associated with primary resistance to anti-EGFR monoclonal antibodies in metastatic colorectal cancer by Mauri, Gianluca, Patelli, Giorgio, Gori, Viviana, Lauricella, Calogero, Mussolin, Benedetta, Amatu, Alessio, Bencardino, Katia, Tosi, Federica, Bonazzina, Erica, Bonoldi, Emanuela, Bardelli, Alberto, Siena, Salvatore, Sartore-Bianchi, Andrea

“…[This corrects the article DOI: 10.3389/fonc.2022.1030232.]…”
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High Circulating Methylated DNA Is a Negative Predictive and Prognostic Marker in Metastatic Colorectal Cancer Patients Treated With Regorafenib by Amatu, Alessio, Schirripa, Marta, Tosi, Federica, Lonardi, Sara, Bencardino, Katia, Bonazzina, Erica, Palmeri, Laura, Patanè, Damiano Alfio, Pizzutilo, Elio Gregory, Mussolin, Benedetta, Bergamo, Francesca, Alberti, Giulia, Intini, Rossana, Procaccio, Letizia, Arese, Marco, Marsoni, Silvia, Nichelatti, Michele, Zagonel, Vittorina, Siena, Salvatore, Bardelli, Alberto, Loupakis, Fotios, Di Nicolantonio, Federica, Sartore-Bianchi, Andrea, Barault, Ludovic

“…Regorafenib improves progression free survival (PFS) in a subset of metastatic colorectal cancer (mCRC) patients, although no biomarkers of efficacy are…”
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Whole exome sequencing analysis of urine trans-renal tumour DNA in metastatic colorectal cancer patients by Crisafulli, Giovanni, Mussolin, Benedetta, Cassingena, Andrea, Montone, Monica, Bartolini, Alice, Barault, Ludovic, Martinetti, Antonia, Morano, Federica, Pietrantonio, Filippo, Sartore-Bianchi, Andrea, Siena, Salvatore, Di Nicolantonio, Federica, Marsoni, Silvia, Bardelli, Alberto, Siravegna, Giulia

“…BackgroundThe analysis of circulating free tumour DNA (ctDNA) in blood, commonly referred as liquid biopsy, is being used to characterise patients with solid…”
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Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth by Germano, Giovanni, Lamba, Simona, Rospo, Giuseppe, Barault, Ludovic, Magrì, Alessandro, Maione, Federica, Russo, Mariangela, Crisafulli, Giovanni, Bartolini, Alice, Lerda, Giulia, Siravegna, Giulia, Mussolin, Benedetta, Frapolli, Roberta, Montone, Monica, Morano, Federica, de Braud, Filippo, Amirouchene-Angelozzi, Nabil, Marsoni, Silvia, D’Incalci, Maurizio, Orlandi, Armando, Giraudo, Enrico, Sartore-Bianchi, Andrea, Siena, Salvatore, Pietrantonio, Filippo, Di Nicolantonio, Federica, Bardelli, Alberto

“…The inactivation of DNA mismatch repair in cancer cells produces dynamic mutational profiles and generates neoantigens, which result in improved immune…”
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Circulating tumor DNA to guide rechallenge with panitumumab in metastatic colorectal cancer: the phase 2 CHRONOS trial by Sartore-Bianchi, Andrea, Pietrantonio, Filippo, Lonardi, Sara, Mussolin, Benedetta, Rua, Francesco, Crisafulli, Giovanni, Bartolini, Alice, Fenocchio, Elisabetta, Amatu, Alessio, Manca, Paolo, Bergamo, Francesca, Tosi, Federica, Mauri, Gianluca, Ambrosini, Margherita, Daniel, Francesca, Torri, Valter, Vanzulli, Angelo, Regge, Daniele, Cappello, Giovanni, Marchiò, Caterina, Berrino, Enrico, Sapino, Anna, Marsoni, Silvia, Siena, Salvatore, Bardelli, Alberto

“…Anti-epidermal growth factor receptor (EGFR) monoclonal antibodies are approved for the treatment of RAS wild-type (WT) metastatic colorectal cancer (mCRC),…”
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Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients by Siravegna, Giulia, Mussolin, Benedetta, Buscarino, Michela, Corti, Giorgio, Cassingena, Andrea, Crisafulli, Giovanni, Ponzetti, Agostino, Cremolini, Chiara, Amatu, Alessio, Lauricella, Calogero, Lamba, Simona, Hobor, Sebastijan, Avallone, Antonio, Valtorta, Emanuele, Rospo, Giuseppe, Medico, Enzo, Motta, Valentina, Antoniotti, Carlotta, Tatangelo, Fabiana, Bellosillo, Beatriz, Veronese, Silvio, Budillon, Alfredo, Montagut, Clara, Racca, Patrizia, Marsoni, Silvia, Falcone, Alfredo, Corcoran, Ryan B, Di Nicolantonio, Federica, Loupakis, Fotios, Siena, Salvatore, Sartore-Bianchi, Andrea, Bardelli, Alberto

“…By monitoring ctDNA, the authors reveal the dynamic adaption of clonal populations in colorectal cancer patients treated with anti-EGFR therapy, suggesting…”
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Polyclonal Secondary FGFR2 Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion-Positive Cholangiocarcinoma by Goyal, Lipika, Saha, Supriya K, Liu, Leah Y, Siravegna, Giulia, Leshchiner, Ignaty, Ahronian, Leanne G, Lennerz, Jochen K, Vu, Phuong, Deshpande, Vikram, Kambadakone, Avinash, Mussolin, Benedetta, Reyes, Stephanie, Henderson, Laura, Sun, Jiaoyuan Elisabeth, Van Seventer, Emily E, Gurski, Jr, Joseph M, Baltschukat, Sabrina, Schacher-Engstler, Barbara, Barys, Louise, Stamm, Christelle, Furet, Pascal, Ryan, David P, Stone, James R, Iafrate, A John, Getz, Gad, Porta, Diana Graus, Tiedt, Ralph, Bardelli, Alberto, Juric, Dejan, Corcoran, Ryan B, Bardeesy, Nabeel, Zhu, Andrew X

“…Genetic alterations in the fibroblast growth factor receptor (FGFR) pathway are promising therapeutic targets in many cancers, including intrahepatic…”
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Multicenter Evaluation of Circulating Cell-Free DNA Extraction and Downstream Analyses for the Development of Standardized (Pre)analytical Work Flows by Lampignano, Rita, Neumann, Martin H.D, Weber, Sabrina, Kloten, Vera, Herdean, Andrei, Voss, Thorsten, Groelz, Daniel, Babayan, Anna, Tibbesma, Marco, Schlumpberger, Martin, Chemi, Francesca, Rothwell, Dominic G, Wikman, Harriet, Galizzi, Jean-Pierre, Riise Bergheim, Inger, Russnes, Hege, Mussolin, Benedetta, Bonin, Serena, Voigt, Christine, Musa, Hanny, Pinzani, Pamela, Lianidou, Evi, Brady, Ged, Speicher, Michael R, Pantel, Klaus, Betsou, Fay, Schuuring, Ed, Kubista, Mikael, Ammerlaan, Wim, Sprenger-Haussels, Markus, Schlange, Thomas, Heitzer, Ellen

“…Abstract BACKGROUND In cancer patients, circulating cell-free DNA (ccfDNA) can contain tumor-derived DNA (ctDNA), which enables noninvasive diagnosis,…”
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Genetic Evolution of Glioblastoma Stem‐Like Cells From Primary to Recurrent Tumor by Orzan, Francesca, De Bacco, Francesca, Crisafulli, Giovanni, Pellegatta, Serena, Mussolin, Benedetta, Siravegna, Giulia, D'Ambrosio, Antonio, Comoglio, Paolo M., Finocchiaro, Gaetano, Boccaccio, Carla

“…Glioblastoma (GBM) is a lethal tumor that displays remarkable genetic heterogeneity. It is also known that GBM contains a cell hierarchy driven by GBM…”
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Memory CD8+ T cell diversity and B cell responses correlate with protection against SARS-CoV-2 following mRNA vaccination by Brasu, Nadia, Elia, Ines, Russo, Valentina, Montacchiesi, Gaia, Stabile, Simona Aversano, De Intinis, Carlo, Fesi, Francesco, Gizzi, Katiuscia, Macagno, Marco, Montone, Monica, Mussolin, Benedetta, Grifoni, Alba, Faravelli, Silvia, Marchese, Silvia, Forneris, Federico, De Francesco, Raffaele, Sette, Alessandro, Barnaba, Vincenzo, Sottile, Antonino, Sapino, Anna, Pace, Luigia

“…Understanding immune responses to SARS-CoV-2 messenger RNA (mRNA) vaccines is of great interest, principally because of the poor knowledge about the mechanisms…”
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Improving individualized monitoring strategy for Rituximab treatment in patients with Neuromyelitis Optica Spectrum Disorders: development of a high sensitive ddPCR assay for CD19 mRNA quantification (4123) by Bertolotto, Antonio, Valentino, Paola, Mirabile, Luca, Bertolo, Jessica, Mussolin, Benedetta, Siravegna, Giulia, Martire, Serena, Marnetto, Fabiana

“…Abstract only…”
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Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer by Siravegna, Giulia, Lazzari, Luca, Crisafulli, Giovanni, Sartore-Bianchi, Andrea, Mussolin, Benedetta, Cassingena, Andrea, Martino, Cosimo, Lanman, Richard B., Nagy, Rebecca J., Fairclough, Stephen, Rospo, Giuseppe, Corti, Giorgio, Bartolini, Alice, Arcella, Pamela, Montone, Monica, Lodi, Francesca, Lorenzato, Annalisa, Vanzati, Alice, Valtorta, Emanuele, Cappello, Giovanni, Bertotti, Andrea, Lonardi, Sara, Zagonel, Vittorina, Leone, Francesco, Russo, Mariangela, Balsamo, Antonella, Truini, Mauro, Di Nicolantonio, Federica, Amatu, Alessio, Bonazzina, Erica, Ghezzi, Silvia, Regge, Daniele, Vanzulli, Angelo, Trusolino, Livio, Siena, Salvatore, Marsoni, Silvia, Bardelli, Alberto

“…Targeting HER2 is effective in 24% of ERBB2 amplified metastatic colorectal cancer; however, secondary resistance occurs in most of the cases. We studied the…”
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