Candida parapsilosis Fungemia Associated with Implantable and Semi-Implantable Central Venous Catheters and the Hands of Healthcare Workers

A cluster of six cases of fungemia among hematology, bone marrow transplant, and oncology patients was investigated in a case-control study (18 controls). The use of implantable and semi-implantable central venous catheters was significantly associated with cases ( p = 0.016). The hands of three hea...

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Bibliographic Details
Published in:	Diagnostic microbiology and infectious disease Vol. 30; no. 4; pp. 243 - 249
Main Authors:	Levin, A.S, Costa, S.F, Mussi, N.S, Basso, M, Sinto, S.I, Machado, C, Geiger, D.C, Villares, M.C.B, Schreiber, A.Z, Barone, A.A, Branchini, M.L.M
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-04-1998 Elsevier
Subjects:	Adolescent Adult Aged Biological and medical sciences Candidiasis - drug therapy Candidiasis - etiology Candidiasis - microbiology Case-Control Studies Catheterization, Central Venous - adverse effects Child Child, Preschool Cross Infection - drug therapy Cross Infection - epidemiology Cross Infection - microbiology Female Fungemia - drug therapy Fungemia - etiology Fungemia - microbiology Hand - microbiology Health Personnel Human mycoses Humans Infectious diseases Male Medical sciences Middle Aged Miscellaneous mycoses Mycoses Yeast Iatrogenic Intravenous administration Mycosis Catheter Hand Candida parapsilosis Fungi Infection Fungemia Complication Fungi Imperfecti Health worker Biological contamination Hygiene Thallophyta
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Summary:	A cluster of six cases of fungemia among hematology, bone marrow transplant, and oncology patients was investigated in a case-control study (18 controls). The use of implantable and semi-implantable central venous catheters was significantly associated with cases ( p = 0.016). The hands of three healthcare workers (HCWs) were positive for Candida parapsilosis. Electrophoretic karyotyping showed two profiles among patients and HCWs, and five among six unrelated strains. The profiles of two HCWs matched the ones of the patients they had handled. The patients’ strains were moderate or strong slime producers, whereas none of the HCWs’ were strong producers. In conclusion, our results indicated the occurrence of an outbreak C. parapsilosis fungemia related to long-term central venous catheters in which the hands of HCWs were implicated. The amount of slime production might be associated with the pathogenicity of the strains.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0732-8893 1879-0070
DOI:	10.1016/S0732-8893(98)00006-6