Search Results - "Musselman, Catherine"

Histone Tail Conformations: A Fuzzy Affair with DNA by Ghoneim, Mohamed, Fuchs, Harrison A., Musselman, Catherine A.

“…The core histone tails are critical in chromatin structure and signaling. Studies over the past several decades have provided a wealth of information on the…”
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Perceiving the epigenetic landscape through histone readers by Musselman, Catherine A, Lalonde, Marie-Eve, Côté, Jacques, Kutateladze, Tatiana G

“…Histone post-translational modifications (PTMs) can directly influence histone-DNA and histone-histone interactions, or they can be targeted by protein…”
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Dynamic views of molecular recognition in protein-nucleic acid complexes by Musselman, Catherine A., Valkov, Eugene

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Reading More than Histones: The Prevalence of Nucleic Acid Binding among Reader Domains by Weaver, Tyler M, Morrison, Emma A, Musselman, Catherine A

“…The eukaryotic genome is packaged into the cell nucleus in the form of chromatin, a complex of genomic DNA and histone proteins. Chromatin structure regulation…”
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Single-Molecule Characterization of Cy3.5 -Cy5.5 Dye Pair for FRET Studies of Nucleic Acids and Nucleosomes by Ghoneim, Mohamed, Musselman, Catherine A.

“…Single molecule FRET (Forster resonance energy transfer) is very powerful method for studying biomolecular binding dynamics and conformational transitions…”
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Nucleosome composition regulates the histone H3 tail conformational ensemble and accessibility by Morrison, Emma A, Baweja, Lokesh, Poirier, Michael G, Wereszczynski, Jeff, Musselman, Catherine A

“…Abstract Hexasomes and tetrasomes are intermediates in nucleosome assembly and disassembly. Their formation is promoted by histone chaperones, ATP-dependent…”
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Visualizing Conformational Ensembles of the Nucleosome by NMR by Musselman, Catherine A, Kutateladze, Tatiana G

“…The formation of chromatin not only compacts the eukaryotic genome into the nucleus but also provides a mechanism for the regulation of all DNA templated…”
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The conformation of the histone H3 tail inhibits association of the BPTF PHD finger with the nucleosome by Morrison, Emma A, Bowerman, Samuel, Sylvers, Kelli L, Wereszczynski, Jeff, Musselman, Catherine A

“…Histone tails harbor a plethora of post-translational modifications that direct the function of chromatin regulators, which recognize them through effector…”
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Handpicking epigenetic marks with PHD fingers by Musselman, Catherine A., Kutateladze, Tatiana G.

“…Plant homeodomain (PHD) fingers have emerged as one of the largest families of epigenetic effectors capable of recognizing or 'reading' post-translational…”
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Tcf1 and Lef1 transcription factors establish CD8+ T cell identity through intrinsic HDAC activity by Xing, Shaojun, Li, Fengyin, Zeng, Zhouhao, Zhao, Yunjie, Yu, Shuyang, Shan, Qiang, Li, Yalan, Phillips, Farrah C, Maina, Peterson K, Qi, Hank H, Liu, Chengyu, Zhu, Jun, Pope, R Marshall, Musselman, Catherine A, Zeng, Chen, Peng, Weiqun, Xue, Hai-Hui

“…Xue and colleagues show that the transcription factors Tcf1 and Lef1 suppress CD4 + T lineage genes in CD8 + T cells through intrinsic histone deacetylase…”
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PBRM1 bromodomains associate with RNA to facilitate chromatin association by De Silva, Saumya M, Dhiman, Alisha, Sood, Surbhi, Mercedes, Kilsia F, Simmons, William J, Henen, Morkos A, Vögeli, Beat, Dykhuizen, Emily C, Musselman, Catherine A

“…Abstract PBRM1 is a subunit of the PBAF chromatin remodeling complex, which is mutated in 40–50% of clear cell renal cell carcinoma patients. It is thought to…”
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E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator by Guo, Ang, Wang, Yihui, Chen, Biyi, Wang, Yunhao, Yuan, Jinxiang, Zhang, Liyang, Hall, Duane, Wu, Jennifer, Shi, Yun, Zhu, Qi, Chen, Cheng, Thiel, William H, Zhan, Xin, Weiss, Robert M, Zhan, Fenghuang, Musselman, Catherine A, Pufall, Miles, Zhu, Weizhong, Au, Kin Fai, Hong, Jiang, Anderson, Mark E, Grueter, Chad E, Song, Long-Sheng

“…Junctophilin-2 (JP2) is a structural protein required for normal excitation-contraction (E-C) coupling. After cardiac stress, JP2 is cleaved by the calcium…”
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Towards understanding methyllysine readout by Musselman, Catherine A., Khorasanizadeh, Sepideh, Kutateladze, Tatiana G.

“…Lysine methylation is the most versatile covalent posttranslational modification (PTM) found in histones and non-histone proteins. Over the past decade a…”
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Characterization of functional disordered regions within chromatin-associated proteins by Musselman, Catherine A., Kutateladze, Tatiana G.

“…Intrinsically disordered regions (IDRs) are abundant and play important roles in the function of chromatin-associated proteins (CAPs). These regions are often…”
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DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes by Morrison, Emma A., Sanchez, Julio C., Ronan, Jehnna L., Farrell, Daniel P., Varzavand, Katayoun, Johnson, Jenna K., Gu, Brian X., Crabtree, Gerald R., Musselman, Catherine A.

“…BRG1 and BRM, central components of the BAF (mSWI/SNF) chromatin remodelling complex, are critical in chromatin structure regulation. Here, we show that the…”
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Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1 by Musselman, Catherine A, Avvakumov, Nikita, Watanabe, Reiko, Abraham, Christopher G, Lalonde, Marie-Eve, Hong, Zehui, Allen, Christopher, Roy, Siddhartha, Nuñez, James K, Nickoloff, Jac, Kulesza, Caroline A, Yasui, Akira, Côté, Jacques, Kutateladze, Tatiana G

“…The human Polycomb-like protein PHF1 has been implicated in transcription-regulatory and DNA damage repair pathways. A new study demonstrates that the Tudor…”
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Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor by Wang, Sijie, Denton, Kyle E, Hobbs, Kathryn F, Weaver, Tyler, McFarlane, James M. B, Connelly, Katelyn E, Gignac, Michael C, Milosevich, Natalia, Hof, Fraser, Paci, Irina, Musselman, Catherine A, Dykhuizen, Emily C, Krusemark, Casey J

“…Polycomb repressive complex 1 (PRC1) is critical for mediating gene expression during development. Five chromobox (CBX) homolog proteins, CBX2, CBX4, CBX6,…”
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The PHD finger of Spp1 mediates histone modification cross-talk by Musselman, Catherine A, Kutateladze, Tatiana G

“…Binding of the Spp1 PHD finger to histone H3K4me3 is sensitive to adjacent post-translational modifications in the histone tail. This commentary discusses the…”
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Accessibility of the histone H3 tail in the nucleosome for binding of paired readers by Gatchalian, Jovylyn, Wang, Xiaodong, Ikebe, Jinzen, Cox, Khan L., Tencer, Adam H., Zhang, Yi, Burge, Nathaniel L., Di, Luo, Gibson, Matthew D., Musselman, Catherine A., Poirier, Michael G., Kono, Hidetoshi, Hayes, Jeffrey J., Kutateladze, Tatiana G.

“…Combinatorial polyvalent contacts of histone-binding domains or readers commonly mediate localization and activities of chromatin-associated proteins. A pair…”
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Evolutionary Conservation of Structural and Functional Coupling between the BRM AT-Hook and Bromodomain by Lupo, Brianna E., Chu, Peirou, Harms, Michael J., Morrison, Emma A., Musselman, Catherine A.

“…[Display omitted] •The BAF complex contains multiple regulatory histone/DNA binding domains of unknown activity.•Several elements in the BRG1/BRM…”
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