Search Results - "Mussell, Ashley L."
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VGLL4 Selectively Represses YAP-Dependent Gene Induction and Tumorigenic Phenotypes in Breast Cancer
Published in Scientific reports (21-07-2017)“…Members of the mammalian Vestigial-like (VGLL) family of transcriptional cofactors activate genes in response to a wide variety of environmental cues…”
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NTRK1 is a positive regulator of YAP oncogenic function
Published in Oncogene (01-04-2019)“…Multiple cancer signalling networks take part in regulatory crosstalks with the Hippo tumour suppressor pathway through the transcriptional cofactor…”
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3
Regulation of local GTP availability controls RAC1 activity and cell invasion
Published in Nature communications (19-10-2021)“…Physiological changes in GTP levels in live cells have never been considered a regulatory step of RAC1 activation because intracellular GTP concentration…”
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Author Correction: Regulation of local GTP availability controls RAC1 activity and cell invasion
Published in Nature communications (05-11-2021)Get full text
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5
The Hippo Signaling Transducer TAZ Regulates Mammary Gland Morphogenesis and Carcinogen-induced Mammary Tumorigenesis
Published in Scientific reports (24-04-2018)“…Hippo signaling pathway is an evolutionarily conserved pathway that controls organ size by regulating cell proliferation, apoptosis and stem cell self-renewal…”
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Targeting TAZ-Driven Human Breast Cancer by Inhibiting a SKP2-p27 Signaling Axis
Published in Molecular cancer research (01-01-2019)“…Deregulated expression of the transcriptional coactivator with PDZ-binding motif (WWTR1/TAZ) is a common feature of basal-like breast cancer (BLBC). Yet, how…”
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Loss of KIBRA function activates EGFR signaling by inducing AREG
Published in Oncotarget (06-07-2018)“…The Hippo signaling pathway is a central regulator of organ size, tissue homeostasis, and tumorigenesis. KIBRA is a member of the WW domain-containing protein…”
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The Regulatory Role of KIBRA and PTPN14 in Hippo Signaling and Beyond
Published in Genes (27-05-2016)“…The Hippo signaling pathway regulates cellular proliferation and survival, thus exerting profound effects on normal cell fate and tumorigenesis. Pivotal…”
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Journal Article Book Review -
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Phosphorylation of Tyr188 in the WW domain of YAP1 plays an essential role in YAP1-induced cellular transformation
Published in Cell cycle (Georgetown, Tex.) (16-09-2016)“…The Hippo signaling pathway regulates cellular proliferation and survival, thus exerting profound effects on normal cell fate and tumorigenesis. The pivotal…”
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Phosphorylation of Tyr188 in the WW domain of YAP1 plays an essential role in YAP1-induced cellular transformation
Published in Cell Cycle (16-09-2016)“…The Hippo signaling pathway regulates cellular proliferation and survival, thus exerting profound effects on normal cell fate and tumorigenesis. The pivotal…”
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