The prognostic role of the epithelial-mesenchymal transition markers E-cadherin and Slug in laryngeal squamous cell carcinoma

Aims Laryngeal squamous cell carcinoma (LSCC) prognosis is definitely related to lymph node metastasis. Epithelial–mesenchymal transition (EMT) allows neoplastic cells to gain the plasticity and motility required for tumour progression and metastasis. The aim of this study was to investigate the rol...

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Published in:	Histopathology Vol. 67; no. 4; pp. 491 - 500
Main Authors:	Cappellesso, Rocco, Marioni, Gino, Crescenzi, Marika, Giacomelli, Luciano, Guzzardo, Vincenza, Mussato, Alessio, Staffieri, Alberto, Martini, Alessandro, Blandamura, Stella, Fassina, Ambrogio
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01-10-2015 Wiley Subscription Services, Inc
Subjects:	Aged Biomarkers, Tumor - analysis Cadherins - analysis Cadherins - biosynthesis Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Disease-Free Survival Epithelial-Mesenchymal Transition Female Head and Neck Neoplasms - mortality Head and Neck Neoplasms - pathology Humans Immunohistochemistry laryngeal carcinoma Laryngeal Neoplasms - mortality Laryngeal Neoplasms - pathology Male Middle Aged neck lymph node metastasis Neoplasm Recurrence, Local - pathology Prognosis Proportional Hazards Models Reverse Transcriptase Polymerase Chain Reaction Snail Family Transcription Factors Squamous Cell Carcinoma of Head and Neck Transcription Factors - analysis Transcription Factors - biosynthesis epithelial-mesenchymal transition neck lymph node metastasis laryngeal carcinoma prognosis
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Summary:	Aims Laryngeal squamous cell carcinoma (LSCC) prognosis is definitely related to lymph node metastasis. Epithelial–mesenchymal transition (EMT) allows neoplastic cells to gain the plasticity and motility required for tumour progression and metastasis. The aim of this study was to investigate the role of EMT in the prognosis of LSCC. Methods and results Immunohistochemical analysis of E‐cadherin, N‐cadherin, Snail, Slug, ZEB1, and ZEB2 was performed in 37 consecutive LSCC cases. Low E‐cadherin levels and high Slug levels correlated with both disease recurrence (P = 0.02 and P =0.01, respectively) and shorter disease‐free survival (DFS) (P = 0.04 and P = 0.02, respectively). Relative expression levels of CDH1, SNAI2, miR‐1 and the miR‐200 family were also evaluated. CDH1, miR‐200a and miR‐200c down‐regulation and SNAI2 overexpression were significantly associated with disease recurrence (P = 0.03, P = 0.02, P = 0.04, and P = 0.04, respectively). Conclusions EMT increases tumour recurrence risk and shortens DFS in LSCC. E‐cadherin and Slug immunohistochemical analysis could be useful for identifying patients requiring more aggressive treatment after surgery.
Bibliography:	ArticleID:HIS12668 istex:B610CD74621D568EAC4C62FEC43D1B42C6140B9E ark:/67375/WNG-XSRZJSD1-M ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0309-0167 1365-2559
DOI:	10.1111/his.12668