Search Results - "Musich, Phillip R."

Chimeric antigen receptor T-cell therapy in glioblastoma: charging the T cells to fight by Land, Craig A, Musich, Phillip R, Haydar, Dalia, Krenciute, Giedre, Xie, Qian

“…Glioblastoma multiforme (GBM) is the most common malignant brain cancer that invades normal brain tissue and impedes surgical eradication, resulting in early…”
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ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1 by Hilton, Benjamin A., Li, Zhengke, Musich, Phillip R., Wang, Hui, Cartwright, Brian M., Serrano, Moises, Zhou, Xiao Zhen, Lu, Kun Ping, Zou, Yue

“…ATR, a PI3K-like protein kinase, plays a key role in regulating DNA damage responses. Its nuclear checkpoint kinase function is well documented, but little is…”
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DNA-damage accumulation and replicative arrest in Hutchinson-Gilford progeria syndrome by Musich, Phillip R, Zou, Yue

“…A common feature of progeria syndromes is a premature aging phenotype and an enhanced accumulation of DNA damage arising from a compromised repair system. HGPS…”
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Progerin sequestration of PCNA promotes replication fork collapse and mislocalization of XPA in laminopathy‐related progeroid syndromes by Hilton, Benjamin A., Liu, Ji, Cartwright, Brian M., Liu, Yiyong, Breitman, Maya, Wang, Youjie, Jones, Rowdy, Tang, Hui, Rusinol, Antonio, Musich, Phillip R., Zou, Yue

“…ABSTRACT Hutchinson‐Gilford progeria syndrome (HGPS) is a rare genetic disorder that is caused by a point mutation in the LMNA gene, resulting in production of…”
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Tyrosine kinase signaling-independent MET-targeting with CAR-T cells by Qin, Anna, Qin, Yuan, Lee, Joseph, Musket, Anna, Ying, Mingyao, Krenciute, Giedre, Marincola, Francesco M, Yao, Zhi Q, Musich, Phillip R, Xie, Qian

“…Recent progress in cancer immunotherapy encourages the expansion of chimeric antigen receptor (CAR) T cell therapy in solid tumors including hepatocellular…”
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Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A by Musich, Phillip R, Zou, Yue

“…Progeria syndromes have in common a premature aging phenotype and increased genome instability. The susceptibility to DNA damage arises from a compromised…”
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Phosphorylation-Dependent Pin1 Isomerization of ATR: Its Role in Regulating ATR's Anti-apoptotic Function at Mitochondria, and the Implications in Cancer by Makinwa, Yetunde, Musich, Phillip R, Zou, Yue

“…Peptidyl-prolyl isomerization is an important post-translational modification of protein because proline is the only amino acid that can stably exist as and ,…”
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Receptor tyrosine kinases as druggable targets in glioblastoma: Do signaling pathways matter? by Qin, Anna, Musket, Anna, Musich, Phillip R, Schweitzer, John B, Xie, Qian

“…Glioblastoma (GBM) is the most malignant primary brain tumor without effective therapies. Since bevacizumab was FDA approved for targeting vascular endothelial…”
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DSTYK Promotes Metastasis and Chemoresistance via EMT in Colorectal Cancer by Zhang, Jinyu, Miller, Zachary, Musich, Phillip R, Thomas, Ashlin E, Yao, Zhi Q, Xie, Qian, Howe, Philip H, Jiang, Yong

“…Tumor metastasis and resistance to chemotherapy are two critical factors that contribute to the high death rate of colorectal cancer (CRC) patients. Metastasis…”
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The application of exosomes in the treatment of triple-negative breast cancer by Weaver, John W., Zhang, Jinyu, Rojas, Juan, Musich, Phillip R., Yao, Zhiqiang, Jiang, Yong

“…Triple-negative breast cancer (TNBC) is a heterogeneous and invasive breast cancer (BC) subtype that is estrogen receptor-negative, progesterone…”
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A new structural insight into XPA-DNA interactions by Hilton, Benjamin, Shkriabai, Nick, Musich, Phillip R, Kvaratskhelia, Mamuka, Shell, Steven, Zou, Yue

“…XPA (xeroderma pigmentosum group A) protein is an essential factor for NER (nucleotide excision repair) which is believed to be involved in DNA damage…”
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Synthesis and Encapsulation of a New Zinc Phthalocyanine Photosensitizer into Polymeric Nanoparticles to Enhance Cell Uptake and Phototoxicity by Mehraban, Nahid, Musich, Phillip, Freeman, Harold

“…Efforts to enhance the utility of photodynamic therapy as a non-invasive method for treating certain cancers have often involved the design of dye sensitizers…”
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Differential responses of MET activations to MET kinase inhibitor and neutralizing antibody by Kou, Jianqun, Musich, Phillip R, Staal, Ben, Kang, Liang, Qin, Yuan, Yao, Zhi Q, Zhang, Boheng, Wu, Weizhong, Tam, Angela, Huang, Alan, Hao, Huai-Xiang, Vande Woude, George F, Xie, Qian

“…Aberrant MET tyrosine kinase signaling is known to cause cancer initiation and progression. While MET inhibitors are in clinical trials against several cancer…”
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UV-induced nuclear import of XPA is mediated by importin-α4 in an ATR-dependent manner by Li, Zhengke, Musich, Phillip R, Cartwright, Brian M, Wang, Hui, Zou, Yue

“…Xeroderma pigmentosum Group A (XPA) is a crucial factor in mammalian nucleotide excision repair (NER) and nuclear import of XPA from the cytoplasm for NER is…”
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Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure by Wang, Yan, Xu, Erin, Musich, Phillip R., Lin, Fang

“…Summary Mitochondria not only supply the energy for cell function, but also take part in cell signaling. This review describes the dysfunctions of mitochondria…”
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Wnt2 Contributes to the Development of Atherosclerosis by Zhang, Jinyu, Rojas, Samuel, Singh, Sanjay, Musich, Phillip R, Gutierrez, Matthew, Yao, Zhiqiang, Thewke, Douglas, Jiang, Yong

“…Atherosclerosis, is a chronic inflammatory disease, characterized by the narrowing of the arteries resulting from the formation of intimal plaques in the wall…”
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Dissociation Dynamics of XPC-RAD23B from Damaged DNA Is a Determining Factor of NER Efficiency by Hilton, Benjamin, Gopal, Sathyaraj, Xu, Lifang, Mazumder, Sharmistha, Musich, Phillip R, Cho, Bongsup P, Zou, Yue

“…XPC-RAD23B (XPC) plays a critical role in human nucleotide excision repair (hNER) as this complex recognizes DNA adducts to initiate NER. To determine the…”
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DSTYK Enhances Chemoresistance in Triple-Negative Breast Cancer Cells by Ogbu, Stella C, Rojas, Samuel, Weaver, John, Musich, Phillip R, Zhang, Jinyu, Yao, Zhi Q, Jiang, Yong

“…Breast cancer, as the most prevalent cancer in women, is responsible for more than 15% of new cancer cases and about 6.9% of all cancer-related death in the…”
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Prolyl Isomerization-Mediated Conformational Changes Define ATR Subcellular Compartment-Specific Functions by Biswas, Himadri, Zhao, Shu-Jun, Makinwa, Yetunde, Bassett, James S., Musich, Phillip R., Liu, Jing-Yuan, Zou, Yue

“…ATR is a PI3K-like kinase protein, regulating checkpoint responses to DNA damage and replication stress. Apart from its checkpoint function in the nucleus, ATR…”
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Checkpoint Kinase ATR Promotes Nucleotide Excision Repair of UV-induced DNA Damage via Physical Interaction with Xeroderma Pigmentosum Group A by Shell, Steven M., Li, Zhengke, Shkriabai, Nikolozi, Kvaratskhelia, Mamuka, Brosey, Chris, Serrano, Moises A., Chazin, Walter J., Musich, Phillip R., Zou, Yue

“…In response to DNA damage, eukaryotic cells activate a series of DNA damage-dependent pathways that serve to arrest cell cycle progression and remove DNA…”
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