Search Results - "Musiani, Piero"

Constitutively Active Stat3 Enhances Neu-Mediated Migration and Metastasis in Mammary Tumors via Upregulation of Cten by BARBIERI, Isaia, PENSA, Sara, PROVERO, Paolo, MUSIANI, Piero, POLI, Valeria, PANNELLINI, Tania, QUAGLINO, Elena, MARITANO, Diego, DEMARIA, Marco, VOSTER, Alessandra, TURKSON, James, CAVALLO, Federica, WATSON, Christine J

“…The transcription factor signal transducer and activator of transcription 3 (STAT3) is constitutively activated in tumors of different origin, but the…”
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MicroRNA gene expression deregulation in human breast cancer by IORIO, Marilena V, FERRACIN, Manuela, MENARD, Sylvie, PALAZZO, Juan P, ROSENBERG, Anne, MUSIANI, Piero, VOLINIA, Stefano, NENCI, Italo, COLIN, George A, QUERZOLI, Patrizia, NEGRINI, Massimo, CROCE, Carlo M, LIU, Chang-Gong, VERONESE, Angelo, SPIZZO, Riccardo, SABBIONI, Silvia, MAGRI, Eros, PEDRIALI, Massimo, FABBRI, Muller, CAMPIGLIO, Manuela

“…MicroRNAs (miRNAs) are a class of small noncoding RNAs that control gene expression by targeting mRNAs and triggering either translation repression or RNA…”
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Oxidative Stress, Mutations and Chromosomal Aberrations Induced by In Vitro and In Vivo Exposure to Furan by Russo, Maria Teresa, De Luca, Gabriele, Palma, Nieves, Leopardi, Paola, Degan, Paolo, Cinelli, Serena, Pepe, Gaetano, Mosesso, Pasquale, Di Carlo, Emma, Sorrentino, Carlo, Musiani, Piero, Crebelli, Riccardo, Bignami, Margherita, Dogliotti, Eugenia

“…Furan is a volatile compound that is formed in foods during thermal processing. It is classified as a possible human carcinogen by international authorities…”
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Nitroaspirin Corrects Immune Dysfunction in Tumor-Bearing Hosts and Promotes Tumor Eradication by Cancer Vaccination by De Santo, Carmela, Serafini, Paolo, Marigo, Ilaria, Dolcetti, Luigi, Bolla, Manlio, Del Soldato, Piero, Melani, Cecilia, Guiducci, Cristiana, Colombo, Mario P., Iezzi, Manuela, Musiani, Piero, Zanovello, Paola, Bronte, Vincenzo, Ignarro, Louis J.

“…Active suppression of tumor-specific T lymphocytes can limit the immune-mediated destruction of cancer cells. Of the various strategies used by tumors to…”
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The human splice variant Δ16HER2 induces rapid tumor onset in a reporter transgenic mouse by Marchini, Cristina, Gabrielli, Federico, Iezzi, Manuela, Zenobi, Santa, Montani, Maura, Pietrella, Lucia, Kalogris, Cristina, Rossini, Anna, Ciravolo, Valentina, Castagnoli, Lorenzo, Tagliabue, Elda, Pupa, Serenella M, Musiani, Piero, Monaci, Paolo, Menard, Sylvie, Amici, Augusto

“…Several transgenic mice models solidly support the hypothesis that HER2 (ERBB2) overexpression or mutation promotes tumorigenesis. Recently, a HER2 splice…”
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The intriguing role of polymorphonuclear neutrophils in antitumor reactions by Di Carlo, Emma, Forni, Guido, Lollini, PierLuigi, Colombo, Mario P., Modesti, Andrea, Musiani, Piero

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Role of MUTYH and MSH2 in the Control of Oxidative DNA Damage, Genetic Instability, and Tumorigenesis by RUSSO, Maria Teresa, DE LUCA, Gabriele, CASORELLI, Ida, DEGAN, Paolo, MOLATORE, Sara, BARONE, Flavia, MAZZEI, Filomena, PANNELLINI, Tania, MUSIANI, Piero, BIGNAMI, Margherita

“…Mismatch repair is the major pathway controlling genetic stability by removing mispairs caused by faulty replication and/or mismatches containing oxidized…”
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The Lack of Epithelial Interleukin-7 and BAFF/BLyS Gene Expression in Prostate Cancer as a Possible Mechanism of Tumor Escape from Immunosurveillance by DI CARLO, Emma, D'ANTUONO, Tommaso, POMPA, Paolo, GIULIANI, Rossella, ROSINI, Sandra, STUPPIA, Liborio, MUSIANI, Piero, SORRENTINO, Carlo

“…Purpose: The human prostate is endowed with intraepithelial and stromal lymphocytes, which may develop lymphoid follicles (LF) and allow a local immune…”
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Triggering CD40 on endothelial cells contributes to tumor growth by Chiodoni, Claudia, Iezzi, Manuela, Guiducci, Cristiana, Sangaletti, Sabina, Alessandrini, Isabella, Ratti, Chiara, Tiboni, Francesca, Musiani, Piero, Granger, D Neil, Colombo, Mario P

“…Inflammatory cells can either promote or inhibit tumor growth. Here we studied whether CD40, a key molecule for adaptive immune response, has any role in…”
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The Mutyh base excision repair gene influences the inflammatory response in a mouse model of ulcerative colitis by Casorelli, Ida, Pannellini, Tania, De Luca, Gabriele, Degan, Paolo, Chiera, Federica, Iavarone, Ivano, Giuliani, Alessandro, Butera, Alessia, Boirivant, Monica, Musiani, Piero, Bignami, Margherita

“…The Mutyh DNA glycosylase is involved in the repair of oxidized DNA bases. Mutations in the human MUTYH gene are responsible for colorectal cancer in familial…”
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A DNA Vaccine Targeting Angiomotin Inhibits Angiogenesis and Suppresses Tumor Growth by Holmgren, Lars, Ambrosino, Elena, Birot, Olivier, Tullus, Carl, Veitonmäki, Niina, Levchenko, Tetyana, Carlson, Lena-Maria, Musiani, Piero, Iezzi, Manuela, Curcio, Claudia, Forni, Guido, Cavallo, Federica, Kiessling, Rolf

“…Endogenous angiogenesis inhibitors have shown promise in preclinical trials, but clinical use has been hindered by low half-life in circulation and high…”
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IL-18 cDNA Vaccination Protects Mice from Spontaneous Lupus-like Autoimmune Disease by Bossù, Paola, Neumann, Detlef, Del Giudice, Elda, Ciaramella, Antonio, Gloaguen, Isabelle, Fantuzzi, Giamila, Dinarello, Charles A., Di Carlo, Emma, Musiani, Piero, Meroni, Pier Luigi, Caselli, Gianfranco, Ruggiero, Paolo, Boraschi, Diana

“…The lupus-like autoimmune syndrome of MRL/Mp-Tnfrsf6lpr(lpr) mice is characterized by progressive lymphadenopathy and auto-antibody production, leading to…”
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Antimetastatic Activity of a Preventive Cancer Vaccine by NANNI, Patrizia, NICOLETTI, Giordano, IEZZI, Manuela, DE GIOVANNI, Carla, LOLLINI, Pier-Luigi, PALLADINI, Arianna, CROCI, Stefania, MURGO, Annalisa, ANTOGNOLI, Agnese, LANDUZZI, Lorena, FABBI, Marina, FERRINI, Silvano, MUSIANI, Piero

“…The development of prophylactic cancer vaccines that protect healthy hosts from tumor development leaves open the question whether such vaccines are also…”
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Nonredundant roles of antibody, cytokines, and perforin in the eradication of established Her-2/neu carcinomas by Curcio, Claudia, Di Carlo, Emma, Clynes, Raphael, Smyth, Mark J, Boggio, Katia, Quaglino, Elena, Spadaro, Michela, Colombo, Mario P, Amici, Augusto, Lollini, Pier-Luigi, Musiani, Piero, Forni, Guido

“…Since the mechanisms by which specific immunity destroys Her-2/neu carcinoma cells are highly undetermined, these were assessed in BALB/c mice vaccinated with…”
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Interleukin 12-mediated prevention of spontaneous mammary adenocarcinomas in two lines of Her-2/neu transgenic mice by Boggio, K, Nicoletti, G, Di Carlo, E, Cavallo, F, Landuzzi, L, Melani, C, Giovarelli, M, Rossi, I, Nanni, P, De Giovanni, C, Bouchard, P, Wolf, S, Modesti, A, Musiani, P, Lollini, P L, Colombo, M P, Forni, G

“…The ability of interleukin (IL)-12 to prevent tumors when administered to individuals with a genetic risk of cancer was studied in two lines of transgenic mice…”
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Role of STAT3 and PI 3-Kinase/Akt in Mediating the Survival Actions of Cytokines on Sensory Neurons by Alonzi, Tonino, Middleton, Gayle, Wyatt, Sean, Buchman, Vladimir, A. K. Betz, Ulrich, Müller, Werner, Musiani, Piero, Poli, Valeria, Davies, Alun M.

“…The binding of cytokines to the gp130 receptor activates the STAT3, MEK/MAPK, and PI3K/Akt signalling pathways. To assess the relative importance of these…”
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Cure of Mammary Carcinomas in Her-2 Transgenic Mice through Sequential Stimulation of Innate (Neoadjuvant Interleukin-12) and Adaptive (DNA Vaccine Electroporation) Immunity by SPADARO, Michela, AMBROSINO, Elena, CAVALLO, Federica, FORNI, Guido, IEZZI, Manuela, DI CARLO, Emma, SACCHETTI, Pamela, CURCIO, Claudia, AMICI, Augusto, WEI, Wei-Zen, MUSIANI, Piero, LOLLINI, Pier-Luigi

“…Purpose: Whereas neoadjuvant therapy is emerging as a treatment option in early primary breast cancer, no data are available on the use of antiangiogenic and…”
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Inhibition of mammary carcinoma development in HER-2/neu transgenic mice through induction of autoimmunity by xenogeneic DNA vaccination by PUPA, Serenella M, IEZZI, Manuela, DI CARLO, Emma, INVERNIZZI, Annamaria, CAVALLO, Federica, MEAZZA, Raffaella, COMES, Alberto, FERRINI, Silvano, MUSIANI, Piero, MENARD, Sylvie

“…Plasmid DNA vectors encoding the full-length (VR1012/HER-2-FL) or only the extracellular and transmembrane domains (VR1012/HER-2-ECD-TM) of human (h) HER-2/neu…”
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Intramammary application of non-methylated-CpG oligodeoxynucleotides (CpG) inhibits both local and systemic mammary carcinogenesis in female BALB/c Her-2/neu transgenic mice by Mastini, Cristina, Becker, Pablo D, Iezzi, Manuela, Curcio, Claudia, Musiani, Piero, Forni, Guido, Cavallo, Federica, Guzmán, Carlos A

“…CpG are powerful drugs activating the innate immune system. In this study, the ability of their intramammary administration in impeding the devastating…”
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Toward a Long-Lasting Immune Prevention of HER2 Mammary Carcinomas: Directions from Transgenic Mice by Calogero, Raffaele A., Musiani, Piero, Forni, Guido, Cavallo, Federica

“…Several theoretical and practical issues differentiate immune prevention from tumor immune therapy. The latter seeks to induce a rapid reaction against a…”
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