Search Results - "Musch, Timothy I."

August Krogh's theory of muscle microvascular control and oxygen delivery: a paradigm shift based on new data by Poole, David C., Pittman, Roland N., Musch, Timothy I., Østergaard, Leif

“…August Krogh twice won the prestigious international Steegen Prize, for nitrogen metabolism (1906) and overturning the concept of active transport of gases…”
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Muscle oxygen transport and utilization in heart failure: implications for exercise (in)tolerance by Poole, David C, Hirai, Daniel M, Copp, Steven W, Musch, Timothy I

“…The defining characteristic of chronic heart failure (CHF) is an exercise intolerance that is inextricably linked to structural and functional aberrations in…”
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Dynamic Heterogeneity of Exercising Muscle Blood Flow and O2 Utilization by KOGA, SHUNSAKU, ROSSITER, HARRY B, HEINONEN, ILKKA, MUSCH, TIMOTHY I, POOLE, DAVID C

“…ABSTRACTResolving the bases for different physiological functioning or exercise performance within a population is dependent on our understanding of control…”
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Impact of dietary nitrate supplementation via beetroot juice on exercising muscle vascular control in rats by Ferguson, Scott K., Hirai, Daniel M., Copp, Steven W., Holdsworth, Clark T., Allen, Jason D., Jones, Andrew M., Musch, Timothy I., Poole, David C.

“…Key points •  Inorganic nitrate (NO3−) supplementation with beetroot juice (BR) in humans lowers blood pressure and the O2 cost of exercise and may improve…”
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Skeletal muscle capillary function: contemporary observations and novel hypotheses by Poole, David C., Copp, Steven W., Ferguson, Scott K., Musch, Timothy I.

“…New findings •  What is the topic of this review? This review presents the paradigm shift in our understanding of capillary structure and function that has…”
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Skeletal muscle interstitial O2 pressures: bridging the gap between the capillary and myocyte by Hirai, Daniel M., Colburn, Trenton D., Craig, Jesse C., Hotta, Kazuki, Kano, Yutaka, Musch, Timothy I., Poole, David C.

“…The oxygen transport pathway from air to mitochondria involves a series of transfer steps within closely integrated systems (pulmonary, cardiovascular, and…”
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Skeletal muscle interstitial Po2 kinetics during recovery from contractions by Hirai, Daniel M, Craig, Jesse C, Colburn, Trenton D, Eshima, Hiroaki, Kano, Yutaka, Musch, Timothy I, Poole, David C

“…The oxygen partial pressure in the interstitial space (Po2 is) drives O2 into the myocyte via diffusion, thus supporting oxidative phosphorylation. Although…”
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Pulmonary hypertension alters blood flow distribution and impairs the hyperemic response in the rat diaphragm by Schulze, Kiana M, Horn, Andrew G, Weber, Ramona E, Behnke, Bradley J, Poole, David C, Musch, Timothy I

“…Pulmonary hypertension (PH) is characterized by pulmonary vascular remodeling, respiratory muscle and cardiac impairments, and exercise intolerance…”
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Respiratory muscle blood flow during exercise: Effects of sex and ovarian cycle by Smith, Joshua R, Hageman, K Sue, Harms, Craig A, Poole, David C, Musch, Timothy I

“…Sex and ovarian cycle have been speculated to modify respiratory muscle blood flow control during exercise, but the findings are inconclusive. We tested the…”
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Effect of chronic heart failure in older rats on respiratory muscle and hindlimb blood flow during submaximal exercise by Smith, Joshua R, Hageman, K. Sue, Harms, Craig A, Poole, David C, Musch, Timothy I

“…Highlights • Chronic heart failure (CHF) disproportionally afflicts older adults. • We examined if older CHF rats had elevated diaphragm BF during exercise. •…”
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Wharton's jelly or bone marrow mesenchymal stromal cells improve cardiac function following myocardial infarction for more than 32 weeks in a rat model: a preliminary report by López, Yelica, Lutjemeier, Barbara, Seshareddy, Kiran, Trevino, Elizabeth M, Hageman, K Sue, Musch, Timothy I, Borgarelli, Michele, Weiss, Mark L

“…The therapeutic effect of mesenchymal stromal cells (MSCs) following myocardial infarction (MI) is small. This may be due to differences in cellular sources…”
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Systemic NOS inhibition reduces contracting muscle oxygenation more in intact female than male rats by Tabuchi, Ayaka, Craig, Jesse C., Hirai, Daniel M., Colburn, Trenton D., Kano, Yutaka, Poole, David C., Musch, Timothy I.

“…Females respond to baroreceptor stimulation with enhanced modulation of heart rate (HR) to regulate blood pressure and also express greater reliance on nitric…”
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Control of microvascular oxygen pressures in rat muscles comprised of different fibre types by McDonough, Paul, Behnke, Brad J., Padilla, Danielle J., Musch, Timothy I., Poole, David C.

“…In response to an elevated metabolic rate , increased microvascular blood–muscle O 2 flux is the product of both augmented O 2 delivery and fractional O 2…”
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Effects of nitrate supplementation via beetroot juice on contracting rat skeletal muscle microvascular oxygen pressure dynamics by Ferguson, Scott K, Hirai, Daniel M, Copp, Steven W, Holdsworth, Clark T, Allen, Jason D, Jones, Andrew M, Musch, Timothy I, Poole, David C

“…Highlights • Dietary NO3− (via beetroot juice, BR) augments exercising muscle blood flow. • We examined the effects of BR on contracting rat muscle…”
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Effects of Type II diabetes on capillary hemodynamics in skeletal muscle by Padilla, Danielle J, McDonough, Paul, Behnke, Brad J, Kano, Yutaka, Hageman, K Sue, Musch, Timothy I, Poole, David C

“…Microcirculatory red blood cell (RBC) hemodynamics are impaired within skeletal muscle of Type I diabetic rats (Kindig CA, Sexton WL, Fedde MR, and Poole DC…”
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Exercise training and muscle microvascular oxygenation: functional role of nitric oxide by Hirai, Daniel M, Copp, Steven W, Ferguson, Scott K, Holdsworth, Clark T, McCullough, Danielle J, Behnke, Bradley J, Musch, Timothy I, Poole, David C

“…Exercise training induces multiple adaptations within skeletal muscle that may improve local O(2) delivery-utilization matching (i.e., Po(2)mv). We tested the…”
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Modulation of rat skeletal muscle microvascular O2 pressure via KATP channel inhibition following the onset of contractions by Holdsworth, Clark T, Ferguson, Scott K, Poole, David C, Musch, Timothy I

“…Highlights • Vascular ATP-sensitive K+ (KATP ) channel activation enhances exercise-induced hyperemia. • We examined the effect of KATP channel inhibition via…”
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Regulation of capillary hemodynamics by KATP channels in resting skeletal muscle by Hirai, Daniel M., Tabuchi, Ayaka, Craig, Jesse C., Colburn, Trenton D., Musch, Timothy I., Poole, David C.

“…ATP‐sensitive K+ channels (KATP) have been implicated in the regulation of resting vascular smooth muscle membrane potential and tone. However, whether KATP…”
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Head‐up tilt does not enhance prostate tumor perfusion or oxygenation in young rats by Kunkel, Olivia N., Rand, Taylor A., Pyle, Joseph G., Baumfalk, Dryden R., Horn, Andrew G., Opoku‐Acheampong, Alexander B., Ade, Carl J., Musch, Timothy I., Ramsey, Michael W., Delp, Michael D., Behnke, Bradley J.

“…Solid tumors contain hypoxic regions that contribute to anticancer therapy resistance. Thus, mitigating tumor hypoxia may enhance the efficacy of radiation…”
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Thromboxane A2 receptors contribute to the exaggerated exercise pressor reflex in male rats with heart failure by Butenas, Alec L. E., Rollins, Korynne S., Williams, Auni C., Parr, Shannon K., Hammond, Stephen T., Ade, Carl J., Hageman, K. Sue, Musch, Timothy I., Copp, Steven W.

“…Mechanical and metabolic signals associated with skeletal muscle contraction stimulate the sensory endings of thin fiber muscle afferents and produce reflex…”
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