Search Results - "Musah, Samira"

Uncovering SARS-CoV-2 kidney tropism by Musah, Samira

“…Samira Musah highlights work by Puelles et al. investigating multi-organ affinity of SARS-CoV-2 and its high infectivity of the kidneys…”
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Mechanosensitive Differentiation of Human iPS Cell-Derived Podocytes by Zhang, Yize, Musah, Samira

“…Stem cell fate decisions, including proliferation, differentiation, morphological changes, and viability, are impacted by microenvironmental cues such as…”
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Engineered In Vitro Disease Models by Benam, Kambez H, Dauth, Stephanie, Hassell, Bryan, Herland, Anna, Jain, Abhishek, Jang, Kyung-Jin, Karalis, Katia, Kim, Hyun Jung, MacQueen, Luke, Mahmoodian, Roza, Musah, Samira, Torisawa, Yu-suke, van der Meer, Andries D, Villenave, Remi, Yadid, Moran, Parker, Kevin K, Ingber, Donald E

“…The ultimate goal of most biomedical research is to gain greater insight into mechanisms of human disease or to develop new and improved therapies or…”
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Fenestrated Endothelial Cells across Organs: Insights into Kidney Function and Disease by Mou, Xingrui, Leeman, Sophia M, Roye, Yasmin, Miller, Carmen, Musah, Samira

“…In the human body, the vascular system plays an indispensable role in maintaining homeostasis by supplying oxygen and nutrients to cells and organs and…”
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Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip by Musah, Samira, Mammoto, Akiko, Ferrante, Thomas C., Jeanty, Sauveur S. F., Hirano-Kobayashi, Mariko, Mammoto, Tadanori, Roberts, Kristen, Chung, Seyoon, Novak, Richard, Ingram, Miles, Fatanat-Didar, Tohid, Koshy, Sandeep, Weaver, James C., Church, George M., Ingber, Donald E.

“…An in vitro model of the human kidney glomerulus—the major site of blood filtration—could facilitate drug discovery and illuminate kidney-disease mechanisms…”
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Substratum-induced differentiation of human pluripotent stem cells reveals the coactivator YAP is a potent regulator of neuronal specification by Musah, Samira, Wrighton, Paul J., Zaltsman, Yefim, Zhong, Xiaofen, Zorn, Stefan, Parlato, Matthew B., Hsiao, Cheston, Palecek, Sean P., Chang, Qiang, Murphy, William L., Kiessling, Laura L.

“…Physical stimuli can act in either a synergistic or antagonistic manner to regulate cell fate decisions, but it is less clear whether insoluble signals alone…”
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A Personalized Glomerulus Chip Engineered from Stem Cell-Derived Epithelium and Vascular Endothelium by Roye, Yasmin, Bhattacharya, Rohan, Mou, Xingrui, Zhou, Yuhao, Burt, Morgan A, Musah, Samira

“…Progress in understanding kidney disease mechanisms and the development of targeted therapeutics have been limited by the lack of functional in vitro models…”
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SARS-CoV-2 Employ BSG/CD147 and ACE2 Receptors to Directly Infect Human Induced Pluripotent Stem Cell-Derived Kidney Podocytes by Kalejaiye, Titilola D, Bhattacharya, Rohan, Burt, Morgan A, Travieso, Tatianna, Okafor, Arinze E, Mou, Xingrui, Blasi, Maria, Musah, Samira

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the Coronavirus disease 2019 (COVID-19), which has resulted in over 5.9 million deaths…”
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A Biomimetic Electrospun Membrane Supports the Differentiation and Maturation of Kidney Epithelium from Human Stem Cells by Mou, Xingrui, Shah, Jessica, Bhattacharya, Rohan, Kalejaiye, Titilola D, Sun, Bowen, Hsu, Po-Chun, Musah, Samira

“…Podocytes derived from human induced pluripotent stem (hiPS) cells are enabling studies of kidney development and disease. However, many of these studies are…”
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Unleashing the power of biomaterials to enhance organoid differentiation and function by Musah, Samira, Arzaghi, Hamidreza

“…Biomaterials are revolutionizing organoid development by offering tunable platforms that provide instructive cues, which enhance cell fate transitions,…”
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Isogenic Kidney Glomerulus Chip Engineered from Human Induced Pluripotent Stem Cells by Roye, Yasmin, Musah, Samira

“…Chronic kidney disease (CKD) affects 15% of the U.S. adult population, but the establishment of targeted therapies has been limited by the lack of functional…”
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Kidney Disease Modeling with Organoids and Organs-on-Chips by Musah, Samira, Bhattacharya, Rohan, Himmelfarb, Jonathan

“…Kidney disease is a global health crisis affecting more than 850 million people worldwide. In the United States, annual Medicare expenditures for kidney…”
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Early-career researchers in the time of COVID-19: Adapting to uncertainty

“…A recurring theme throughout our year-long “Introductions to the community: Early-career researchers in the time of COVID-19” Voices series was resiliency and…”
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High-Throughput Discovery of Novel Therapeutic Candidates for Human Podocytopathies: SA-PO328 by Barreto, Amanda, Burt, Morgan A., Samanta, Labannya, Musah, Samira

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Directed differentiation of human induced pluripotent stem cells into mature kidney podocytes and establishment of a Glomerulus Chip by Musah, Samira, Dimitrakakis, Nikolaos, Camacho, Diogo M., Church, George M., Ingber, Donald E.

“…Protocols have been established to direct the differentiation of human induced pluripotent stem (iPS) cells into nephron progenitor cells and organoids…”
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Harnessing developmental plasticity to pattern kidney organoids by Bhattacharya, Rohan, Bonner, Makenzie G., Musah, Samira

“…Methods for deriving the ureteric epithelium (UE) in vitro could improve understanding of kidney development and patterning. In this issue of Cell Stem Cell,…”
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Microfluidic systems for modeling human development by Bonner, Makenzie G, Gudapati, Hemanth, Mou, Xingrui, Musah, Samira

“…The proper development and patterning of organs rely on concerted signaling events emanating from intracellular and extracellular molecular and biophysical…”
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Advancing drug discovery for glomerulopathies using stem-cell-derived kidney models by Barreto, Amanda D., Burt, Morgan A., Musah, Samira

“…Chronic kidney disease (CKD) is an epidemic that affects millions worldwide. The glomerulus, a specialized unit of the nephron, is highly susceptible to…”
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An ultrathin membrane mediates tissue-specific morphogenesis and barrier function in a human kidney chip by Mou, Xingrui, Shah, Jessica, Roye, Yasmin, Du, Carolyn, Musah, Samira

“…Organ-on-chip (OOC) systems are revolutionizing tissue engineering by providing dynamic models of tissue structure, organ-level function, and disease…”
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A human stem cell-derived model reveals pathologic extracellular matrix remodeling in diabetic podocyte injury by Roye, Yasmin, Miller, Carmen, Kalejaiye, Titilola D., Musah, Samira

“…•A human iPS cell-derived model of hyperglycemia-induced podocytopathy recapitulates hallmarks of podocyte injury.•Excess deposition of the embryonic isoform…”
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