Search Results - "Murtaugh, William"

Efficacy and safety of dolutegravir with emtricitabine and tenofovir alafenamide fumarate or tenofovir disoproxil fumarate, and efavirenz, emtricitabine, and tenofovir disoproxil fumarate HIV antiretroviral therapy regimens started in pregnancy (IMPAACT 2010/VESTED): a multicentre, open-label, randomised, controlled, phase 3 trial by Lockman, Shahin, Brummel, Sean S, Ziemba, Lauren, Stranix-Chibanda, Lynda, McCarthy, Katie, Coletti, Anne, Jean-Philippe, Patrick, Johnston, Ben, Krotje, Chelsea, Fairlie, Lee, Hoffman, Risa M, Sax, Paul E, Moyo, Sikhulile, Chakhtoura, Nahida, Stringer, Jeffrey SA, Masheto, Gaerolwe, Korutaro, Violet, Cassim, Haseena, Mmbaga, Blandina T, João, Esau, Hanley, Sherika, Purdue, Lynette, Holmes, Lewis B, Momper, Jeremiah D, Shapiro, Roger L, Thoofer, Navdeep K, Rooney, James F, Frenkel, Lisa M, Amico, K Rivet, Chinula, Lameck, Currier, Judith, Best, Brookie M., Blanchette, Cheryl, Browning, Renee, Cheng, Yao, Fox, Andee, Jaliaah, Nagawa, Knowles, Kevin, Mirochnick, Mark, Murtaugh, William A., Patras, Emmanuel, Pinilla, Mauricio, van Wyk, Jean, Whalen, Frances

“…Antiretroviral therapy (ART) during pregnancy is important for both maternal health and prevention of perinatal HIV-1 transmission; however adequate data on…”
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The Use of a Shared Services Model for Mycobacteriology Testing: Lessons Learned by Stafford, Cortney, Atkinson-Dunn, Robyn, Buss, Sarah N., Dalton, Tracy, Gibson, Debbie, Johnston, Stephanie, King, Ewa, Lin, Shou-Yean Grace, Mitchell, Kara K., Murtaugh, William A., Sease, Heather, Southern, Timothy R., Tans-Kersten, Julie L., Travanty, Emily A., Triplett, Laura R., Wroblewski, Kelly, Starks, Angela M.

“…Objectives: Public health laboratories (PHLs) provide essential services in the diagnosis and surveillance of diseases of public health concern, such as…”
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Evaluation of Three Influenza Neuraminidase Inhibition Assays for Use in a Public Health Laboratory Setting During the 2011—2012 Influenza Season by Murtaugh, William, Mahaman, Lalla, Healey, Benjamin, Peters, Heather, Anderson, Barbara, Tran, Mandy, Ziese, Marci, Carlos, Maria Paz

“…Objectives. We evaluated the implementation of three commericially available neuraminidase inhibition assays in a public health laboratory (PHL) setting. We…”
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168. Mumps Seroprevalence Among Detained Youth in Maryland, 2011: Local, Regional and National Policy Implications by Bokor, Brooke Rosman, MD, MPH, Maehr, Jennifer, MD, Trivedi, Leena, PhD, Washington, Yvette, MS, Murtaugh, William, BS, Carlos, Maria Paz, PhD, Thakore, Gira, MBBS

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QT effects of bedaquiline, delamanid, or both in patients with rifampicin-resistant tuberculosis: a phase 2, open-label, randomised, controlled trial by Dooley, Kelly E, Rosenkranz, Susan L, Conradie, Francesca, Moran, Laura, Hafner, Richard, von Groote-Bidlingmaier, Florian, Lama, Javier R., Shenje, Justin, De Los Rios, Jorge, Comins, Kyla, Morganroth, Joel, Diacon, Andreas H, Cramer, Yoninah S, Donahue, Kathleen, Maartens, Gary, Alli, Oladapo, Gottesman, Joan, Guevara, Maria, Hikuam, Chris, Hovind, Laura, Karlsson, Mats, McClaren, Jennifer, McIlleron, Helen, Murtaugh, William, Rolls, Barbara, Shahkolahi, Akbar, Stone, Lynnett, Tegha, Gerald, Tenai, Jacob, Upton, Caryn, Wimbish, Chanelle

“…Bedaquiline and delamanid are the first drugs of new classes registered for tuberculosis treatment in 40 years. Each can prolong the QTc interval, with maximum…”
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Early Bactericidal Activity of Different Isoniazid Doses for Drug-Resistant Tuberculosis (INHindsight): A Randomized, Open-Label Clinical Trial by Dooley, Kelly E, Miyahara, Sachiko, von Groote-Bidlingmaier, Florian, Sun, Xin, Hafner, Richard, Rosenkranz, Susan L, Ignatius, Elisa H, Nuermberger, Eric L, Moran, Laura, Donahue, Kathleen, Swindells, Susan, Vanker, Naadira, Diacon, Andreas H

“…High-dose isoniazid is recommended in short-course regimens for multidrug-resistant tuberculosis (TB). The optimal dose of isoniazid and its individual…”
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Symptom and Viral Rebound in Untreated SARS-CoV-2 Infection by Deo, Rinki, Choudhary, Manish C, Moser, Carlee, Ritz, Justin, Daar, Eric S, Wohl, David A, Greninger, Alexander L, Eron, Joseph J, Currier, Judith S, Hughes, Michael D, Smith, Davey M, Chew, Kara W, Li, Jonathan Z

“…Although symptom and viral rebound have been reported after nirmatrelvir-ritonavir treatment, the trajectories of symptoms and viral load during the natural…”
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Pooling Different Placebos as a Control Group in a Randomized Platform Trial: Benefits and Challenges From Experience in the ACTIV-2 COVID-19 Trial by Moser, Carlee B, Chew, Kara W, Ritz, Justin, Newell, Matthew, Javan, Arzhang Cyrus, Eron, Joseph J, Daar, Eric S, Wohl, David A, Currier, Judith S, Smith, Davey M, Hughes, Michael D

“…Abstract Adaptive platform trials were implemented during the coronavirus disease 2019 (COVID-19) pandemic to rapidly evaluate therapeutics, including the…”
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Viral and symptom rebound following anti-SARS-CoV-2 monoclonal antibody therapy in a randomized placebo-controlled trial by Chew, Kara W, McGinley, Brooke, Moser, Carlee, Li, Jonathan Z, Evering, Teresa H, Ritz, Justin, Javan, Arzhang Cyrus, Margolis, David, Wohl, David A, Hughes, Michael D, Daar, Eric S, Currier, Judith S, Eron, Joseph J, Smith, Davey M

“…We explored viral and symptom rebound after COVID-19 amubarvimab/romlusevimab monoclonal antibody therapy vs placebo in the randomized ACTIV-2/A5401 trial…”
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Immune Status and SARS-CoV-2 Viral Dynamics by Li, Yijia, Moser, Carlee, Aga, Evgenia, Currier, Judith S, Wohl, David A, Daar, Eric S, Ritz, Justin, Greninger, Alexander L, Sieg, Scott, Parikh, Urvi M, Coombs, Robert W, Hughes, Michael D, Eron, Joseph J, Smith, Davey M, Chew, Kara W, Li, Jonathan Z

“…Abstract Immunocompromised individuals are disproportionately affected by severe coronavirus disease 2019, but immune compromise is heterogenous, and viral…”
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Statistical Challenges When Analyzing SARS-CoV-2 RNA Measurements Below the Assay Limit of Quantification in COVID-19 Clinical Trials by Moser, Carlee B, Chew, Kara W, Giganti, Mark J, Li, Jonathan Z, Aga, Evgenia, Ritz, Justin, Greninger, Alexander L, Javan, Arzhang Cyrus, Bender Ignacio, Rachel, Daar, Eric S, Wohl, David A, Currier, Judith S, Eron, Joseph J, Smith, Davey M, Hughes, Michael D

“…Abstract Most clinical trials evaluating coronavirus disease 2019 (COVID-19) therapeutics include assessments of antiviral activity. In recently completed…”
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Markers of Maternal Bone and Renal Toxicity Through 50 Weeks Postpartum: IMPAACT 2010 (VESTED) Trial by Masheto, Gaerolwe, Brummel, Sean S, Ziemba, Lauren, Shepherd, John, Mbengeranwa, Tapiwa, Igawa, Laarni, Coletti, Anne, Mukura, Dorinda, Rossouw, Lindie, Theron, Gerhard, Krotje, Chelsea, Jean-Philippe, Patrick, Chakhtoura, Nahida, Cassim, Haseena, Mathiba, Sisinyana Ruth, Maena, Joel, Murtaugh, William, Fairlie, Lee, Currier, Judith, Hoffman, Risa, Chinula, Lameck, Sax, Paul E, Stranix-Chibanda, Lynda, Lockman, Shahin

“…Safety data from randomized trials of antiretrovirals in pregnancy are scarce. We evaluated maternal bone and renal data from the International Maternal…”
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Variant-Specific Viral Kinetics in Acute COVID-19 by Ribeiro, Ruy M, Choudhary, Manish C, Deo, Rinki, Giganti, Mark J, Moser, Carlee, Ritz, Justin, Greninger, Alexander L, Regan, James, Flynn, James P, Wohl, David A, Currier, Judith S, Eron, Joseph J, Hughes, Michael D, Smith, Davey M, Chew, Kara W, Daar, Eric S, Perelson, Alan S, Li, Jonathan Z

“…Abstract Understanding variant-specific differences in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral kinetics may explain differences in…”
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Safety and Efficacy of SAB-185 for Nonhospitalized Adults With COVID-19: A Randomized Clinical Trial by Chew, Kara W, Taiwo, Babafemi O, Moser, Carlee, Daar, Eric S, Wohl, David Alain, Ritz, Justin, Javan, Arzhang Cyrus, Li, Jonathan Z, Fischer, William, Greninger, Alexander L, Bausch, Christoph, Luke, Thomas, Call, Robert, Neytman, Gene, Giganti, Mark J, Fletcher, Courtney V, Hughes, Michael D, Eron, Joseph J, Currier, Judith S, Smith, Davey M, Chew, Kara, Smith, David (Davey), Daar, Eric, Wohl, David, Currier, Judith, Eron, Joseph, Javan, Arzhang Cyrus, Hughes, Michael, Moser, Carlee, Giganti, Mark, Ritz, Justin, Hosey, Lara, Roa, Jhoanna, Patel, Nilam, Colsh, Kelly, Rwakazina, Irene, Beck, Justine, Sieg, Scott, Li, Jonathan, Fletcher, Courtney, Fischer, William, Evering, Teresa, Ignacio, Rachel Bender, Cardoso, Sandra, Corado, Katya, Jagannathan, Prasanna, Jilg, Nikolaus, Perelson, Alan, Pillay, Sandy, Riviere, Cynthia, Singh, Upinder, Taiwo, Babafemi, Gottesman, Joan, Newell, Matthew, Pedersen, Susan, Dragavon, Joan, Jennings, Cheryl, Greenfelder, Brian, Murtaugh, William, Kosmyna, Jan, Gapara, Morgan, Shahkolahi, Akbar

“…Abstract Background We evaluated the fully human polyclonal antibody product SAB-185 in a phase 3 trial for COVID-19. Methods Nonhospitalized high-risk adults…”
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One Week of Oral Camostat Versus Placebo in Nonhospitalized Adults With Mild-to-Moderate Coronavirus Disease 2019: A Randomized Controlled Phase 2 Trial by Jilg, Nikolaus, Chew, Kara W, Giganti, Mark J, Daar, Eric S, Wohl, David A, Javan, Arzhang Cyrus, Kantor, Amy, Moser, Carlee, Coombs, Robert W, Neytman, Gene, Hoover, Keila, Jana, Atasi, Hart, Phil A, Greninger, Alexander L, Szurgot, Bob, Eron, Joseph J, Currier, Judith S, Hughes, Michael D, Smith, Davey M, Li, Jonathan Z

“…Abstract Background Camostat inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in vitro. We studied the safety and efficacy of…”
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Long COVID After Bamlanivimab Treatment by Evering, Teresa H, Moser, Carlee B, Jilg, Nikolaus, Yeh, Eunice, Sanusi, Busola, Wohl, David A, Daar, Eric S, Li, Jonathan Z, Klekotka, Paul, Javan, Arzhang Cyrus, Eron, Joseph J, Currier, Judith S, Hughes, Michael D, Smith, Davey M, Chew, Kara W

“…Abstract Background Prospective evaluations of long COVID in outpatients with coronavirus disease 2019 (COVID-19) are lacking. We aimed to determine the…”
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Resistance-Conferring Mycobacterial Mutations and Quantification of Early Bactericidal Activity by le Roux, Solomon P, Upton, Caryn, Vanker, Naadira, Dooley, Kelly E, Diacon, Andreas H

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Phase 2 Safety and Antiviral Activity of SAB-185, a Novel Polyclonal Antibody Therapy for Nonhospitalized Adults With COVID-19 by Taiwo, Babafemi O, Chew, Kara W, Moser, Carlee, Wohl, David Alain, Daar, Eric S, Li, Jonathan Z, Greninger, Alexander L, Bausch, Christoph, Luke, Thomas, Hoover, Keila, Neytman, Gene, Giganti, Mark J, Olefsky, Maxine, Javan, Arzhang Cyrus, Fletcher, Courtney V, Eron, Joseph J, Currier, Judith S, Hughes, Michael D, Smith, Davey M

“…In this phase 2 evaluation of SAB-185 in the ACTIV-2/ACTG A5401 platform trial of investigational agents for outpatient COVID-19 treatment, this…”
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Association Between Anterior Nasal and Plasma SARS-CoV-2 RNA Levels and Hospitalization or Death in Nonhospitalized Adults With Mild-to-Moderate COVID-19 by Giganti, Mark J, Chew, Kara W, Eron, Joseph J, Li, Jonathan Z, Pinilla, Mauricio, Moser, Carlee, Javan, Arzhang Cyrus, Fischer, William A, Klekotka, Paul, Margolis, David, Wohl, David Alain, Coombs, Robert W, Daar, Eric S, Smith, Davey M, Currier, Judith S, Hughes, Michael D

“…Abstract Background There is little information regarding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA as a predictor for clinical outcomes…”
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Pharmacokinetics and safety of maraviroc in neonates by Rosebush, Julia C., Best, Brookie M., Chadwick, Ellen G., Butler, Kevin, Moye, John, Smith, Elizabeth, Bradford, Sarah, Reding, Christina A., Mathiba, Sisinyana R., Hanley, Sherika, Aziz, Mariam, Homans, James, Acosta, Edward P., Murtaugh, William, Vourvahis, Manoli, Mcfadyen, Lynn, Hayward, Katy, Mirochnick, Mark, Samson, Pearl

“…OBJECTIVE:To evaluate safety and pharmacokinetics (PK) of maraviroc administered with standard antiretroviral prophylaxis to HIV-1 exposed infants and to…”
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