Search Results - "Murta, Silvane M.F"

Novel 2-Nitroimidazole and Imidazooxazole Derivatives and their Activity against Trypanosoma cruzi and Mycobacterium tuberculosis by Faria, Jessica V, Passos, Fernanda P Z, da Costa, Paulo H A, de Oliveira, Andressa P, Cruz, Yasmin O D da, Castelo-Branco, Frederico S, Lourenço, Maria C S, Murta, Silvane M F, Junior, Policarpo A S, Bernardino, Alice M R, Bastos, Monica M, Boechat, Nubia

“…Tuberculosis (TB) is one of the top ten causes of death worldwide, while Chagas disease (CD) is the parasitic disease that kills the largest number of people…”
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Retention and loss of RNA interference pathways in trypanosomatid protozoans by Lye, Lon-Fye, Owens, Katherine, Shi, Huafang, Murta, Silvane M F, Vieira, Ana Carolina, Turco, Salvatore J, Tschudi, Christian, Ullu, Elisabetta, Beverley, Stephen M

“…RNA interference (RNAi) pathways are widespread in metaozoans but the genes required show variable occurrence or activity in eukaryotic microbes, including…”
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Molecular characterization of susceptible and naturally resistant strains of Trypanosoma cruzi to benznidazole and nifurtimox by Murta, Silvane M.F, Gazzinelli, Ricardo T, Brener, Zigman, Romanha, Alvaro J

“…Twenty-seven Trypanosoma cruzi strains, susceptible or naturally resistant to the nitroderivatives benznidazole and nifurtimox, were analyzed using the…”
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Comparative proteomic analysis of antimony-resistant and -susceptible Leishmania braziliensis and Leishmania infantum chagasi lines by Matrangolo, Fabiana S.V., Liarte, Daniel B., Andrade, Laila C., de Melo, Melina F., Andrade, Juvana M., Ferreira, Rafael F., Santiago, André S., Pirovani, Carlos P., Silva-Pereira, Rosiane A., Murta, Silvane M.F.

“…•Proteomic analysis showed 57 distinct proteins LbWTS vs LbSbR and LcWTS vs LcSbR.•Proteins of antioxidant defense, stress and metabolism were differentially…”
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Regulated expression of the Leishmania major surface virulence factor lipophosphoglycan using conditionally destabilized fusion proteins by Madeira da Silva, Luciana, Owens, Katherine L, Murta, Silvane M.F, Beverley, Stephen M

“…Surface glycoconjugates play important roles in the infectious cycle of Leishmania major, including the abundant lipophosphoglycan (LPG) implicated in parasite…”
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Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major by Murta, Silvane M.F, Vickers, Tim J, Scott, David A, Beverley, Stephen M

“…10-Formyl tetrahydrofolate (10-CHO-THF) is a key metabolite in C1 carbon metabolism, arising through the action of formate-tetrahydrofolate ligase (FTL) and/or…”
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Identification of two p23 co‐chaperone isoforms in Leishmania braziliensis exhibiting similar structures and Hsp90 interaction properties despite divergent stabilities by Batista, Fernanda A.H, Almeida, Glessler S, Seraphim, Thiago V, Silva, Kelly P, Murta, Silvane M.F, Barbosa, Leandro R.S, Borges, Júlio C

“…The small acidic protein called p23 acts as a co‐chaperone for heat‐shock protein of 90 kDa (Hsp90) during its ATPase cycle. p23 proteins inhibit Hsp90 ATPase…”
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Biological activities of ophiobolin K and 6-epi-ophiobolin K produced by the endophytic fungus Aspergillus calidoustus by Rodrigues de Carvalho, Camila, Vieira, Mariana de Lourdes Almeida, Cantrell, Charles L, Wedge, David E, Alves, Tânia M.A, Zani, Carlos Leomar, Pimenta, Raphael Sanzio, Sales Junior, Policarpo A, Murta, Silvane M.F, Romanha, Alvaro J, Rosa, Carlos Augusto, Rosa, Luiz H

“…Endophytic fungi represent ubiquitous microbial organisms able to live in the tissues of different plants around the world and represent a prolific source of…”
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Selection and phenotype characterization of potassium antimony tartrate-resistant populations of four New World Leishmania species by Liarte, Daniel B, Murta, Silvane M. F

“…In the present study, we selected in vitro populations of Leishmania Viannia guyanensis, L.V. braziliensis, L. Leishmania amazonensis and L.L. infantum chagasi…”
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The enzymes of the 10-formyl-tetrahydrofolate synthetic pathway are found exclusively in the cytosol of the trypanosomatid parasite Leishmania major by Vickers, Tim J., Murta, Silvane M.F., Mandell, Michael A., Beverley, Stephen M.

“…In most organisms 10-formyl-tetrahydrofolate (10-CHO-THF) participates in the synthesis of purines in the cytosol and formylation of mitochondrial initiator…”
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Kinetics of cytokine gene expression in experimental chagasic cardiomyopathy: tissue parasitism and endogenous IFN-γ as important determinants of chemokine mRNA expression during infection with Trypanosoma cruzi by Talvani, André, Ribeiro, Cristiana S, Aliberti, Júlio C.S, Michailowsky, Vladimir, Santos, Paula V.A, Murta, Silvane M.F, Romanha, Alvaro J, Almeida, Igor C, Farber, Joshua, Lannes-Vieira, Joseli, Silva, João S, Gazzinelli, Ricardo T

“…We investigated the kinetics of parasite replication, leukocyte migration, and cytokine/chemokine mRNA expression in the heart tissue from animals infected…”
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Phylogenetic analysis of Biomphalaria tenagophila (Orbigny, 1835) (Mollusca: Gastropoda) by Jannotti-Passos, Liana K, Ruiz, Jeronimo C, Caldeira, Roberta L, Murta, Silvane M.F, Coelho, Paulo Marcos Z, Carvalho, Omar S

“…Mitochondrial DNA of Biomphalaria tenagophila , a mollusc intermediate host of Schistosoma mansoni in Brazil, was sequenced and characterised. The genome size…”
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Anti-plasmodial and anti-trypanosomal activity of synthetic naphtho[2,3- b]thiophen-4,9-quinones by Zani, Carlos L., Chiari, Egler, Krettli, Antoniana U., Murta, Silvane M.F., Cunningham, Mark L., Fairlamb, Alan H., Romanha, Alvaro J.

“…Naphtho[2,3- b]thiophen-4,9-quinone and five derivatives were prepared using the Friedel-Crafts reaction and tandem-lithiation of aromatic diethylamides. These…”
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Novel gold(I) complexes with 5-phenyl-1,3,4-oxadiazole-2-thione and phosphine as potential anticancer and antileishmanial agents by Chaves, Joana Darc S., Tunes, Luiza Guimarães, de J. Franco, Chris Hebert, Francisco, Thiago Martins, Corrêa, Charlane Cimini, Murta, Silvane M.F., Monte-Neto, Rubens Lima, Silva, Heveline, Fontes, Ana Paula S., de Almeida, Mauro V.

“…The current anticancer and antileishmanial drug arsenal presents several limitations concerning their specificity, efficacy, costs and the emergence of…”
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Pamidronate, a promising repositioning drug to treat leishmaniasis, displays antileishmanial and immunomodulatory potential by Ribeiro, Juliana M., Rodrigues-Alves, Marina L., Oliveira, Edward, Guimarães, Pedro P.G., Maria Murta Santi, Ana, Teixeira-Carvalho, Andrea, Murta, Silvane M.F., Peruhype-Magalhães, Vanessa, Souza-Fagundes, Elaine M.

“…•Pamidronate has activity on the promastigote and amastigote forms of L. infantum in vitro and ex vivo, without toxicity on the cells.•The treatment with…”
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Synthesis and activity of benzimidazole N-Acylhydrazones against Trypanosoma cruzi, Leishmania amazonensis and Leishmania infantum by Ramos, Laís G., de Souza, Kátia R., Barbosa, Juliana M.C., Salomão, Kelly, Sales Junior, Policarpo A., Pereira, Valéria R.A., Murta, Silvane M.F., Ferreira, Rafaela S., Bernardes, Talita C.D., Wardell, Solange M.S.V., Wardell, James L., Boechat, Nubia, Carvalho, Samir A.

“…[Display omitted] •Planning of new Benzimidazole N-acylhydrazones with antitrypanosomal activity.•Biological evaluation of the compounds against T. cruzi…”
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Diversity and bioprospecting of cultivable fungal assemblages in sediments of lakes in the Antarctic Peninsula by Ogaki, Mayara B., Teixeira, Daniela R., Vieira, Rosemary, Lírio, Juan M., Felizardo, João P.S., Abuchacra, Rodrigo C., Cardoso, Renan P., Zani, Carlos L., Alves, Tânia M.A., Junior, Policarpo A.S., Murta, Silvane M.F., Barbosa, Emerson C., Oliveira, Jaquelline G., Ceravolo, Isabela P., Pereira, Patrícia O., Rosa, Carlos A., Rosa, Luiz H.

“…We recovered 195 fungal isolates from the sediments of different lakes in the Antarctic Peninsula, which were screened to detect bioactive compounds. Forty-two…”
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Cultivable fungi present in Antarctic soils: taxonomy, phylogeny, diversity, and bioprospecting of antiparasitic and herbicidal metabolites by Gomes, Eldon C. Q., Godinho, Valéria M., Silva, Débora A. S., de Paula, Maria T. R., Vitoreli, Gislaine A., Zani, Carlos L., Alves, Tânia M. A., Junior, Policarpo A. S., Murta, Silvane M. F., Barbosa, Emerson C., Oliveira, Jaquelline G., Oliveira, Fabio S., Carvalho, Camila R., Ferreira, Mariana C., Rosa, Carlos A., Rosa, Luiz H.

“…Molecular biology techniques were used to identify 218 fungi from soil samples collected from four islands of Antarctica. These consisted of 22 taxa of 15…”
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A functional assay using human whole blood and flow cytometry analysis to evaluate cytotoxicity and immunomodulatory effect of anti-Trypanosoma cruzi drugs by Lopes, Mariana Eduarda A.S. A., Ribeiro, Juliana M., Teixeira-Carvalho, Andréa, Murta, Silvane M.F., Souza-Fagundes, Elaine M.

“…The discovery and development of new drugs for the treatment of Chagas disease is urgent due to the high toxicity and low cure efficacy, mainly during the…”
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Functional analysis of cytosolic tryparedoxin peroxidase in antimony-resistant and –susceptible Leishmania braziliensis and Leishmania infantum lines by Andrade, Juvana M, Murta, Silvane M F

“…BACKGROUND: Tryparedoxin peroxidase (TXNPx) participates in defence against oxidative stress as an antioxidant by metabolizing hydrogen peroxide into water…”
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