Search Results - "Murrell, Sasha"

Bacterially derived synthetic mimetics of mammalian oligomannose prime antibody responses that neutralize HIV infectivity by Pantophlet, Ralph, Trattnig, Nino, Murrell, Sasha, Lu, Naiomi, Chau, Dennis, Rempel, Caitlin, Wilson, Ian A., Kosma, Paul

“…Oligomannose-type glycans are among the major targets on the gp120 component of the HIV envelope protein (Env) for broadly neutralizing antibodies (bnAbs)…”
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Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage Provides Benchmarks for Vaccine Design by Rantalainen, Kimmo, Berndsen, Zachary T., Murrell, Sasha, Cao, Liwei, Omorodion, Oluwarotimi, Torres, Jonathan L., Wu, Mengyu, Umotoy, Jeffrey, Copps, Jeffrey, Poignard, Pascal, Landais, Elise, Paulson, James C., Wilson, Ian A., Ward, Andrew B.

“…Broadly neutralizing antibodies (bnAbs) targeting the HIV envelope glycoprotein (Env) typically take years to develop. Longitudinal analyses of both…”
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Antigen pressure from two founder viruses induces multiple insertions at a single antibody position to generate broadly neutralizing HIV antibodies by Joyce, Collin, Murrell, Sasha, Murrell, Ben, Omorodion, Oluwarotimi, Ver, Lorena S, Carrico, Nancy, Bastidas, Raiza, Nedellec, Rebecca, Bick, Michael, Woehl, Jordan, Zhao, Fangzhu, Burns, Alison, Barman, Shawn, Appel, Michael, Ramos, Alejandra, Wickramasinghe, Lalinda, Eren, Kemal, Vollbrecht, Thomas, Smith, Davey M, Kosakovsky Pond, Sergei L, McBride, Ryan, Worth, Charli, Batista, Facundo, Sok, Devin, Poignard, Pascal, Briney, Bryan, Wilson, Ian A, Landais, Elise, Burton, Dennis R

“…Vaccination strategies aimed at maturing broadly neutralizing antibodies (bnAbs) from naïve precursors are hindered by unusual features that characterize these…”
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Gene-wide identification of episodic selection by Murrell, Ben, Weaver, Steven, Smith, Martin D, Wertheim, Joel O, Murrell, Sasha, Aylward, Anthony, Eren, Kemal, Pollner, Tristan, Martin, Darren P, Smith, Davey M, Scheffler, Konrad, Kosakovsky Pond, Sergei L

“…We present BUSTED, a new approach to identifying gene-wide evidence of episodic positive selection, where the non-synonymous substitution rate is transiently…”
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HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage by Landais, Elise, Murrell, Ben, Briney, Bryan, Murrell, Sasha, Rantalainen, Kimmo, Berndsen, Zachary T., Ramos, Alejandra, Wickramasinghe, Lalinda, Smith, Melissa Laird, Eren, Kemal, de Val, Natalia, Wu, Mengyu, Cappelletti, Audrey, Umotoy, Jeffrey, Lie, Yolanda, Wrin, Terri, Algate, Paul, Chan-Hui, Po-Ying, Karita, Etienne, Ward, Andrew B., Wilson, Ian A., Burton, Dennis R., Smith, Davey, Pond, Sergei L. Kosakovsky, Poignard, Pascal

“…Understanding how broadly neutralizing antibodies (bnAbs) to HIV envelope (Env) develop during natural infection can help guide the rational design of an HIV…”
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Structural Evolution of Broadly Neutralizing Antibodies against HIV during Natural Infection by Murrell, Sasha

“…More than thirty years after its identification as the cause of acquired immune deficiency syndrome (AIDS), human immunodeficiency virus (HIV) remains a…”
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Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth by Willis, Jordan R, Sapparapu, Gopal, Murrell, Sasha, Julien, Jean-Philippe, Singh, Vidisha, King, Hannah G, Xia, Yan, Pickens, Jennifer A, LaBranche, Celia C, Slaughter, James C, Montefiori, David C, Wilson, Ian A, Meiler, Jens, Crowe, Jr, James E

“…Several HIV envelope-targeting (Env-targeting) antibodies with broad and potent neutralizing activity have been identified and shown to have unusual features…”
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HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage by Landais, Elise, Murrell, Ben, Briney, Bryan, Murrell, Sasha, Rantalainen, Kimmo, Berndsen, Zachary T., Ramos, Alejandra, Wickramasinghe, Lalinda, Smith, Melissa Laird, Eren, Kemal, de Val, Natalia, Wu, Mengyu, Cappelletti, Audrey, Umotoy, Jeffrey, Lie, Yolanda, Wrin, Terri, Algate, Paul, Chan-Hui, Po-Ying, Karita, Etienne, Ward, Andrew B., Wilson, Ian A., Burton, Dennis R., Smith, Davey, Pond, Sergei L. Kosakovsky, Poignard, Pascal

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Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage Provides Benchmarks for Vaccine Design by Rantalainen, Kimmo, Berndsen, Zachary T., Murrell, Sasha, Cao, Liwei, Omorodion, Oluwarotimi, Torres, Jonathan L., Wu, Mengyu, Umotoy, Jeffrey, Copps, Jeffrey, Poignard, Pascal, Landais, Elise, Paulson, James C., Wilson, Ian A., Ward, Andrew B.

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The genomes of many yam species contain transcriptionally active endogenous geminiviral sequences that may be functionally expressed by Filloux, Denis, Murrell, Sasha, Koohapitagtam, Maneerat, Golden, Michael, Julian, Charlotte, Galzi, Serge, Uzest, Marilyne, Rodier-Goud, Marguerite, D’Hont, Angélique, Vernerey, Marie Stephanie, Wilkin, Paul, Peterschmitt, Michel, Winter, Stephan, Murrell, Ben, Martin, Darren P., Roumagnac, Philippe

“…Endogenous viral sequences are essentially ‘fossil records’ that can sometimes reveal the genomic features of long extinct virus species. Although numerous…”
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