Search Results - "Murray, Tracey K"

Impaired glymphatic function and clearance of tau in an Alzheimer's disease model by Harrison, Ian F, Ismail, Ozama, Machhada, Asif, Colgan, Niall, Ohene, Yolanda, Nahavandi, Payam, Ahmed, Zeshan, Fisher, Alice, Meftah, Soraya, Murray, Tracey K, Ottersen, Ole P, Nagelhus, Erlend A, O'Neill, Michael J, Wells, Jack A, Lythgoe, Mark F

“…The glymphatic system, that is aquaporin 4 (AQP4) facilitated exchange of CSF with interstitial fluid (ISF), may provide a clearance pathway for protein…”
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Conformation Determines the Seeding Potencies of Native and Recombinant Tau Aggregates by Falcon, Benjamin, Cavallini, Annalisa, Angers, Rachel, Glover, Sarah, Murray, Tracey K., Barnham, Luanda, Jackson, Samuel, O'Neill, Michael J., Isaacs, Adrian M., Hutton, Michael L., Szekeres, Philip G., Goedert, Michel, Bose, Suchira

“…Intracellular Tau inclusions are a pathological hallmark of several neurodegenerative diseases, collectively known as the tauopathies. They include Alzheimer…”
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Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S Tau by Jackson, Samuel J, Kerridge, Caroline, Cooper, Jane, Cavallini, Annalisa, Falcon, Benjamin, Cella, Claire V, Landi, Alessia, Szekeres, Philip G, Murray, Tracey K, Ahmed, Zeshan, Goedert, Michel, Hutton, Michael, O'Neill, Michael J, Bose, Suchira

“…The interneuronal propagation of aggregated tau is believed to play an important role in the pathogenesis of human tauopathies. It requires the uptake of…”
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Transcriptional Signatures of Tau and Amyloid Neuropathology by Castanho, Isabel, Murray, Tracey K., Hannon, Eilis, Jeffries, Aaron, Walker, Emma, Laing, Emma, Baulf, Hedley, Harvey, Joshua, Bradshaw, Lauren, Randall, Andrew, Moore, Karen, O’Neill, Paul, Lunnon, Katie, Collier, David A., Ahmed, Zeshan, O’Neill, Michael J., Mill, Jonathan

“…Alzheimer’s disease (AD) is associated with the intracellular aggregation of hyperphosphorylated tau and the accumulation of β-amyloid in the neocortex. We use…”
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CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease by Weir, Heather J M, Murray, Tracey K, Kehoe, Patrick G, Love, Seth, Verdin, Eric M, O'Neill, Michael J, Lane, Jon D, Balthasar, Nina

“…Progressive mitochondrial dysfunction contributes to neuronal degeneration in age-mediated disease. An essential regulator of mitochondrial function is the…”
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Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model by Wang, Hong, Li, Yupeng, Ryder, John W, Hole, Justin T, Ebert, Philip J, Airey, David C, Qian, Hui-Rong, Logsdon, Benjamin, Fisher, Alice, Ahmed, Zeshan, Murray, Tracey K, Cavallini, Annalisa, Bose, Suchira, Eastwood, Brian J, Collier, David A, Dage, Jeffrey L, Miller, Bradley B, Merchant, Kalpana M, O'Neill, Michael J, Demattos, Ronald B

“…Activation of microglia, the resident immune cells of the central nervous system, is a prominent pathological hallmark of Alzheimer's disease (AD). However,…”
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Imaging the accumulation and suppression of tau pathology using multiparametric MRI by Holmes, Holly E, Colgan, Niall, Ismail, Ozama, Ma, Da, Powell, Nick M, O'Callaghan, James M, Harrison, Ian F, Johnson, Ross A, Murray, Tracey K, Ahmed, Zeshan, Heggenes, Morton, Fisher, Alice, Cardoso, M.J, Modat, Marc, Walker-Samuel, Simon, Fisher, Elizabeth M.C, Ourselin, Sebastien, O'Neill, Michael J, Wells, Jack A, Collins, Emily C, Lythgoe, Mark F

“…Abstract Mouse models of Alzheimer's disease have served as valuable tools for investigating pathogenic mechanisms relating to neurodegeneration, including…”
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Comparison of In Vivo and Ex Vivo MRI for the Detection of Structural Abnormalities in a Mouse Model of Tauopathy by Holmes, Holly E, Powell, Nick M, Ma, Da, Ismail, Ozama, Harrison, Ian F, Wells, Jack A, Colgan, Niall, O'Callaghan, James M, Johnson, Ross A, Murray, Tracey K, Ahmed, Zeshan, Heggenes, Morten, Fisher, Alice, Cardoso, M Jorge, Modat, Marc, O'Neill, Michael J, Collins, Emily C, Fisher, Elizabeth M C, Ourselin, Sébastien, Lythgoe, Mark F

“…With increasingly large numbers of mouse models of human disease dedicated to MRI studies, compromises between and MRI must be fully understood in order to…”
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Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia by Harrison, Ian F, Whitaker, Rozalind, Bertelli, Pietro Maria, O'Callaghan, James M, Csincsik, Lajos, Bocchetta, Martina, Ma, Da, Fisher, Alice, Ahmed, Zeshan, Murray, Tracey K, O'Neill, Michael J, Rohrer, Jonathan D, Lythgoe, Mark F, Lengyel, Imre

“…Visual impairments, such as difficulties in reading and finding objects, perceiving depth and structure from motion, and impaired stereopsis, have been…”
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In Vivo Imaging of Tau Pathology Using Magnetic Resonance Imaging Textural Analysis by Colgan, Niall, Ganeshan, Balaji, Harrison, Ian F, Ismail, Ozama, Holmes, Holly E, Wells, Jack A, Powell, Nick M, O'Callaghan, James M, O'Neill, Michael J, Murray, Tracey K, Ahmed, Zeshan, Collins, Emily C, Johnson, Ross A, Groves, Ashley, Lythgoe, Mark F

“…Non-invasive characterization of the pathological features of Alzheimer's disease (AD) could enhance patient management and the development of therapeutic…”
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Correction to: Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia by Harrison, Ian F, Whitaker, Rozalind, Bertelli, Pietro Maria, O'Callaghan, James M, Csincsik, Lajos, Wells, Jack A, Bocchetta, Martina, Ma, Da, Fisher, Alice, Ahmed, Zeshan, Murray, Tracey K, O'Neill, Michael J, Rohrer, Jonathan D, Lythgoe, Mark F, Lengyel, Imre

“…In the original publication of this article [1], the funding acknowledgement for grant "Alzheimer Society Research Program (ASRP) from the Alzheimer Society of…”
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A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity by Ahmed, Zeshan, Cooper, Jane, Murray, Tracey K., Garn, Katya, McNaughton, Emily, Clarke, Hannah, Parhizkar, Samira, Ward, Mark A., Cavallini, Annalisa, Jackson, Samuel, Bose, Suchira, Clavaguera, Florence, Tolnay, Markus, Lavenir, Isabelle, Goedert, Michel, Hutton, Michael L., O’Neill, Michael J.

“…Intracellular inclusions composed of hyperphosphorylated filamentous tau are a hallmark of Alzheimer’s disease, progressive supranuclear palsy, Pick’s disease…”
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Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression by Chai, Xiyun, Wu, Su, Murray, Tracey K, Kinley, Robert, Cella, Claire V, Sims, Helen, Buckner, Nicola, Hanmer, Jenna, Davies, Peter, O'Neill, Michael J, Hutton, Michael L, Citron, Martin

“…The microtubule-associated protein Tau plays a critical role in the pathogenesis of Alzheimer disease and several related disorders (tauopathies). In the…”
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Loss of MicroRNA-7 Regulation Leads to α-Synuclein Accumulation and Dopaminergic Neuronal Loss In Vivo by McMillan, Kirsty J., Murray, Tracey K., Bengoa-Vergniory, Nora, Cordero-Llana, Oscar, Cooper, Jane, Buckley, Amy, Wade-Martins, Richard, Uney, James B., O’Neill, Michael J., Wong, Liang F., Caldwell, Maeve A.

“…Abnormal alpha-synuclein (α-synuclein) expression and aggregation is a key characteristic of Parkinson’s disease (PD). However, the exact mechanism(s) linking…”
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The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK–PD experiments by Ravenstijn, Paulien G.M., Merlini, Mario, Hameetman, Marjolijn, Murray, Tracey K., Ward, Mark A., Lewis, Hywel, Ball, Gareth, Mottart, Cathy, de Ville de Goyet, Christine, Lemarchand, Thomas, van Belle, Kristel, O'Neill, Michael J., Danhof, Meindert, de Lange, Elizabeth C.M.

“…In search for a suitable rat model to study potentially affected blood-brain barrier (BBB) transport mechanisms in the course of Parkinsons disease (PD)…”
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Evaluation of the mGluR2/3 agonist LY379268 in rodent models of Parkinson's disease by Murray, Tracey K, Messenger, Marcus J, Ward, Mark A, Woodhouse, Sandra, Osborne, David J, Duty, Susan, O'Neill, Michael J

“…The aim of the present studies was to examine the ability of a potent, systemically active, selective Group II mGlu receptor (mGluR2/3) agonist, 1 R,4 R,5 S,6…”
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Neurotrophic actions of the novel AMPA receptor potentiator, LY404187, in rodent models of Parkinson's disease by O'Neill, Michael J, Murray, Tracey K, Whalley, Katherine, Ward, Mark A, Hicks, Caroline A, Woodhouse, Sandra, Osborne, David J, Skolnick, Phil

“…Recent developments in the molecular biology and pharmacology of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors has led to the…”
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Electrical and Network Neuronal Properties Are Preferentially Disrupted in Dorsal, But Not Ventral, Medial Entorhinal Cortex in a Mouse Model of Tauopathy by Booth, Clair A, Ridler, Thomas, Murray, Tracey K, Ward, Mark A, de Groot, Emily, Goodfellow, Marc, Phillips, Keith G, Randall, Andrew D, Brown, Jonathan T

“…The entorhinal cortex (EC) is one of the first areas to be disrupted in neurodegenerative diseases such as Alzheimer's disease and frontotemporal dementia. The…”
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Imbalance in the response of pre- and post-synaptic components to amyloidopathy by Stephen, Terri-Leigh, Tamagnini, Francesco, Piegsa, Judith, Sung, Katherine, Harvey, Joshua, Oliver-Evans, Alice, Murray, Tracey K., Ahmed, Zeshan, Hutton, Michael L., Randall, Andrew, O’Neill, Michael J., Jackson, Johanna S.

“…Alzheimer’s disease (AD)-associated synaptic dysfunction drives the progression of pathology from its earliest stages. Amyloid β (Aβ) species, both soluble and…”
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Synaptic alterations associated with disrupted sensory encoding in a mouse model of tauopathy by Meftah, Soraya, Cavallini, Annalisa, Murray, Tracey K, Jankowski, Lukasz, Bose, Suchira, Ashby, Michael C, Brown, Jonathan T, Witton, Jonathan

“…Synapse loss is currently the best biological correlate of cognitive decline in Alzheimer's disease and other tauopathies. Synapses seem to be highly…”
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