Search Results - "Murray, P G"

Controversies in the diagnosis and management of growth hormone deficiency in childhood and adolescence by Murray, P G, Dattani, M T, Clayton, P E

“…Growth hormone deficiency (GHD) is a rare but important cause of short stature in childhood with a prevalence of 1 in 4000. The diagnosis is currently based on…”
Get full text

Silicon-Based Optical Mirror Coatings for Ultrahigh Precision Metrology and Sensing by Steinlechner, J, Martin, I W, Bell, A S, Hough, J, Fletcher, M, Murray, P G, Robie, R, Rowan, S, Schnabel, R

“…Thermal noise of highly reflective mirror coatings is a major limit to the sensitivity of many precision laser experiments with strict requirements such as low…”
Get full text

The H3K27me3 demethylase, KDM6B, is induced by Epstein-Barr virus and over-expressed in Hodgkin's Lymphoma by Anderton, J A, Bose, S, Vockerodt, M, Vrzalikova, K, Wei, W, Kuo, M, Helin, K, Christensen, J, Rowe, M, Murray, P G, Woodman, C B

“…There is now evidence for both increased and decreased activity of the enzymes controlling the methylation of lysine 27 on histone 3 (H3K27) in cancer. One of…”
Get full text

Hypoxia-regulated carbonic anhydrase IX expression is associated with poor survival in patients with invasive breast cancer by HUSSAIN, S. A, GANESAN, R, JAMES, N. D, SPOONER, D, POOLE, Cj, REA, D. W, PALMER, D. H, REYNOLDS, G, GROSS, L, STEVENS, A, PASTOREK, J, MURRAY, P. G, PERUNOVIC, B, ANWAR, M. S, BILLINGHAM, L

“…Tumour hypoxia is a microenvironmental factor related to poor response to radiation, chemotherapy, genetic instability, selection for resistance to apoptosis,…”
Get full text

role for human endogenous retrovirus-K (HML-2) in rheumatoid arthritis: investigating mechanisms of pathogenesis by Freimanis, G, Hooley, P, Ejtehadi, H. Davari, Ali, H.A, Veitch, A, Rylance, P.B, Alawi, A, Axford, J, Nevill, A, Murray, P.G, Nelson, P.N

“…Human endogenous retroviruses (HERVs) are remnants of ancient retroviral infections within the human genome. These molecular fossils draw parallels with…”
Get full text

Smoking initiation is followed by the early acquisition of epigenetic change in cervical epithelium: a longitudinal study by Ma, Y T, Collins, S I, Young, L S, Murray, P G, Woodman, C B J

“…Background: To prove a causal link between an epigenetic change and an environmental or behavioural risk factor for a given disease, it is first necessary to…”
Get full text

Expression of the Cellular FLICE-Inhibitory Protein (c-FLIP) Protects Hodgkin's Lymphoma Cells from Autonomous Fas-Mediated Death by Dutton, A., O'Neil, J. D., Milner, A. E., Reynolds, G. M., Starczynski, J., Crocker, J., Young, L. S., Murray, P. G., Klein, George

“…Hodgkin's lymphoma (HL) is characterized by the presence of malignant so-called Hodgkin's/Reed-Sternberg (HRS) cells, which display resistance to certain…”
Get full text

Epstein-Barr virus oncoprotein, latent membrane protein-1, reprograms germinal centre B cells towards a Hodgkin's Reed-Sternberg-like phenotype by Vockerodt, M, Morgan, SL, Kuo, M, Wei, W, Chukwuma, MB, Arrand, JR, Kube, D, Gordon, J, Young, LS, Woodman, CB, Murray, PG

“…Although the latent membrane protein-1 (LMP1) of the Epstein-Barr virus (EBV) is believed to be important for the transformation of germinal centre (GC) B…”
Get full text

Inflammation and tissue repair markers distinguish the nodular sclerosis and mixed cellularity subtypes of classical Hodgkin's lymphoma by Birgersdotter, A, Baumforth, K R N, Porwit, A, Sjöberg, J, Wei, W, Björkholm, M, Murray, P G, Ernberg, I

“…Background: Classical Hodgkin's lymphoma (cHL), although a malignant disease, has many features in common with an inflammatory condition. The aim of this study…”
Get full text

Diagnosis of growth hormone deficiency in the paediatric and transitional age by Chinoy, A., MBBS, BSc, MRCPCH, Murray, P.G., Dr

“…Abstract Growth hormone deficiency is a rare cause of childhood short stature, but one for which treatment exists in the form of recombinant human growth…”
Get full text

Reduced appetite and body mass index with delayed puberty in a mother and son: association with a rare novel sequence variant in the leptin gene by Murray, P G, Read, A, Banerjee, I, Whatmore, A J, Pritchard, L E, Davies, R A, Brennand, J, White, A, Ross, R J, Clayton, P E

“…IntroductionLeptin deficiency caused by mutations within the leptin gene (LEP) results in severe early onset obesity, hypogonadism, pubertal delay and immune…”
Get full text

Epstein-Barr virus in breast cancer: artefact or aetiological agent? by Murray, PG

“…The Epstein–Barr virus (EBV) has been reported to be associated with a variety of different tumours; for some of these malignancies, including breast cancer,…”
Get full text

60 YEARS OF NEUROENDOCRINOLOGY: The hypothalamo-GH axis: the past 60 years by Murray, P G, Higham, C E, Clayton, P E

“…At the time of the publication of Geoffrey Harris's monograph on ‘Neural control of the pituitary gland’ 60 years ago, the pituitary was recognised to produce…”
Get full text

Demystified… recombinant antibodies by Smith, K A, Nelson, P N, Warren, P, Astley, S J, Murray, P G, Greenman, J

“…Recombinant antibodies are important tools for biomedical research and are increasingly being used as clinical diagnostic/therapeutic reagents. In this…”
Get full text

Ageing appearance in China: biophysical profile of facial skin and its relationship to perceived age by Mayes, AE, Murray, PG, Gunn, DA, Tomlin, CC, Catt, SD, Wen, YB, Zhou, LP, Wang, HQ, Catt, M, Granger, SP

“…Background  Perceived age is important to women and is a primary driver for topical product use and facial cosmetic surgery. Changes in facial features and…”
Get full text

Likelihood of persistent GH deficiency into late adolescence: relationship to the presence of an ectopic or normally sited posterior pituitary gland by Murray, P.G., Hague, C., Fafoula, O., Gleeson, H., Patel, L., Banerjee, I., Raabe, A.L., Hall, C.M., Wright, N.B., Amin, R., Clayton, P.E.

“…Summary Objectives  The presence of an ectopic posterior pituitary gland (EPP) in childhood is associated with isolated GH deficiency (IGHD) and multiple…”
Get full text

Associations with multiple pituitary hormone deficiency in patients with an ectopic posterior pituitary gland by Murray, P. G., Hague, C., Fafoula, O., Patel, L., Raabe, A. L., Cusick, C., Hall, C. M., Wright, N. B., Amin, R., Clayton, P. E.

“…Summary Introduction  The presence of an ectopic posterior pituitary gland (EPP) on magnetic resonance imaging (MRI) is associated with hypopituitarism with…”
Get full text

Acid phosphatases by Bull, H, Murray, P G, Thomas, D, Fraser, A M, Nelson, P N

“…Acid phosphatases (APs) are a family of enzymes that are widespread in nature, and can be found in many animal and plant species. Mystery surrounds the precise…”
Get full text

Cloning, characterisation and expression analysis of α-glucuronidase from the thermophilic fungus Talaromyces emersonii by Heneghan, M.N., McLoughlin, L., Murray, P.G., Tuohy, M.G.

“…The aguA gene encoding α-glucuronidase was isolated from the thermophilic fungus Talaromyces emersonii by degenerate PCR. AguA has no introns and consists of…”
Get full text

Proapoptotic genes BAX and CD40L are predictors of survival in transitional cell carcinoma of the bladder by HUSSAIN, S. A, GANESAN, R, HILLER, L, MURRAY, P. G, EL-MAGRABY, M. M, YOUNG, L, JAMES, N. D

“…The purpose of the study was to investigate the effects of expression of a range of genes involved in apoptosis on outcome in bladder cancer…”
Get full text