Search Results - "Murray, Jason D"
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Impact of etiology on force and kinetics of left ventricular end-stage failing human myocardium
Published in Journal of molecular and cellular cardiology (01-07-2021)“…Heart failure (HF) is associated with highly significant morbidity, mortality, and health care costs. Despite the significant advances in therapies and…”
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Prednisolone attenuates improvement of cardiac and skeletal contractile function and histopathology by lisinopril and spironolactone in the mdx mouse model of Duchenne muscular dystrophy
Published in PloS one (13-02-2014)“…Duchenne muscular dystrophy (DMD) is an inherited disease that causes striated muscle weakness. Recently, we showed therapeutic effects of the combination of…”
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The force-temperature relationship in healthy and dystrophic mouse diaphragm; implications for translational study design
Published in Frontiers in physiology (01-01-2012)“…In the field of muscular dystrophy, striated muscle function is often assessed in vitro in dystrophin-deficient mdx mice in order to test the impact of a…”
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Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin
Published in Proceedings of the National Academy of Sciences - PNAS (04-06-2019)“…The naturally occurring nucleotide 2-deoxy-adenosine 5′-triphosphate (dATP) can be used by cardiac muscle as an alternative energy substrate for myosin…”
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dATP elevation induces myocardial metabolic remodeling to support improved cardiac function
Published in Journal of molecular and cellular cardiology (01-02-2023)“…Hallmark features of systolic heart failure are reduced contractility and impaired metabolic flexibility of the myocardium. Cardiomyocytes (CMs) with elevated…”
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Low levels of Survival Motor Neuron protein are sufficient for normal muscle function in the SMNΔ7 mouse model of SMA
Published in Human molecular genetics (01-11-2015)“…Spinal Muscular Atrophy (SMA) is an autosomal recessive disorder characterized by loss of lower motor neurons. SMA is caused by deletion or mutation of the…”
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Early Treatment With Lisinopril and Spironolactone Preserves Cardiac and Skeletal Muscle in Duchenne Muscular Dystrophy Mice
Published in Circulation (New York, N.Y.) (02-08-2011)“…Nearly universal cardiomyopathy in Duchenne muscular dystrophy (DMD) contributes to heart failure and death. Because DMD patients show myocardial fibrosis well…”
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Etiology-dependent impairment of relaxation kinetics in right ventricular end-stage failing human myocardium
Published in Journal of molecular and cellular cardiology (01-08-2018)“…In patients with end-stage heart failure, the primary etiology often originates in the left ventricle, and eventually the contractile function of the right…”
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The Effect of Ribonucleotide Reductase Overexpression on Cardiomyocyte Metabolism
Published in Biophysical journal (03-02-2017)Get full text
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RETRACTED: dATP elevation induces myocardial metabolic remodeling to support improved cardiac function
Published in Journal of molecular and cellular cardiology (01-02-2023)“…This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/locate/withdrawalpolicy). This article has been…”
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Ribonucleotide Reductase Overexpression does not Alter Cardiomyocyte Mitochondrial Respiration
Published in Biophysical journal (16-02-2016)Get full text
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Time-Resolved X-Ray Diffraction and Molecular Dynamics Studies of Skeletal Muscle Relaxation with 2 Deoxy-ATP
Published in Biophysical journal (15-02-2019)Get full text
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Abstract 369: Engineering Rrm2 to Elevate 2-deoxy-ATP and Improve Cardiomyocyte Function
Published in Circulation research (21-07-2017)“…Abstract only Overexpression of ribonucleotide reductase (RNR) in cardiomyocytes increases the amount of cytosolic 2-deoxy-ATP (dATP), which can be used by…”
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Enhanced Crossbridge Binding with 2-Deoxy-ATP Results from Increased Electrostatic Interactions between Myosin and Actin in Cardiac Muscle
Published in Biophysical journal (15-02-2019)Get full text
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262 Standard Time Domain Reflectometry Curves for Cyclic Irrigation Management in Container Production
Published in HortScience (01-06-2000)“…The physical properties of soilless substrates used in the nursery industry vary widely throughout the US, and, as such, present problems for accurate…”
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