Search Results - "Murray, H. C."

Vascular smooth muscle cells in atherosclerosis by Basatemur, Gemma L., Jørgensen, Helle F., Clarke, Murray C. H., Bennett, Martin R., Mallat, Ziad

“…Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an atherosclerotic plaque. According to the ‘response to injury’ and…”
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Alternative Pathways of IL-1 Activation, and Its Role in Health and Disease by Pyrillou, Katerina, Burzynski, Laura C, Clarke, Murray C H

“…Cytokines activate or inhibit immune cell behavior and are thus integral to all immune responses. IL-1α and IL-1β are powerful apical cytokines that instigate…”
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Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk by Cassidy, Liam D., Young, Andrew R. J., Young, Christopher N. J., Soilleux, Elizabeth J., Fielder, Edward, Weigand, Bettina M., Lagnado, Anthony, Brais, Rebecca, Ktistakis, Nicholas T., Wiggins, Kimberley A., Pyrillou, Katerina, Clarke, Murray C. H., Jurk, Diana, Passos, Joao F., Narita, Masashi

“…Autophagy is an important cellular degradation pathway with a central role in metabolism as well as basic quality control, two processes inextricably linked to…”
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IL‐1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence‐associated secretory phenotype by Wiggins, Kimberley A., Parry, Aled J., Cassidy, Liam D., Humphry, Melanie, Webster, Steve J., Goodall, Jane C., Narita, Masashi, Clarke, Murray C. H.

“…Interleukin‐1 alpha (IL‐1α) is a powerful cytokine that modulates immunity, and requires canonical cleavage by calpain for full activity. Mature IL‐1α is…”
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The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin by Burzynski, Laura C., Humphry, Melanie, Pyrillou, Katerina, Wiggins, Kimberley A., Chan, Julie N.E., Figg, Nichola, Kitt, Lauren L., Summers, Charlotte, Tatham, Kate C., Martin, Paul B., Bennett, Martin R., Clarke, Murray C.H.

“…Ancient organisms have a combined coagulation and immune system, and although links between inflammation and hemostasis exist in mammals, they are indirect and…”
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Mitochondrial DNA Damage Can Promote Atherosclerosis Independently of Reactive Oxygen Species Through Effects on Smooth Muscle Cells and Monocytes and Correlates With Higher-Risk Plaques in Humans by Yu, Emma, Calvert, Patrick A, Mercer, John R, Harrison, James, Baker, Lauren, Figg, Nichola L, Kumar, Sheetal, Wang, Julie C, Hurst, Liam A, Obaid, Daniel R, Logan, Angela, West, Nick E.J, Clarke, Murray C.H, Vidal-Puig, Antonio, Murphy, Michael P, Bennett, Martin R

“…BACKGROUND—Mitochondrial DNA (mtDNA) damage occurs in both circulating cells and the vessel wall in human atherosclerosis. However, it is unclear whether mtDNA…”
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Vascular Smooth Muscle Cell Apoptosis Induces Interleukin-1–Directed Inflammation: Effects of Hyperlipidemia-Mediated Inhibition of Phagocytosis by Clarke, Murray C.H, Talib, Sara, Figg, Nichola L, Bennett, Martin R

“…RATIONALE:Atherosclerosis is characterized by lipid accumulation in the vessel wall, inflammation, and both macrophage and vascular smooth muscle cell (VSMC)…”
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Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis by Bennett, Martin R, Clarke, Murray C H, Figg, Nichola, Maguire, Janet J, Davenport, Anthony P, Goddard, Martin, Littlewood, Trevor D

“…Vascular smooth muscle cell (VSMC) apoptosis occurs in many arterial diseases, including aneurysm formation, angioplasty restenosis and atherosclerosis…”
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Chronic Apoptosis of Vascular Smooth Muscle Cells Accelerates Atherosclerosis and Promotes Calcification and Medial Degeneration by Clarke, Murray C.H, Littlewood, Trevor D, Figg, Nichola, Maguire, Janet J, Davenport, Anthony P, Goddard, Martin, Bennett, Martin R

“…Vascular smooth muscle cell (VSMC) accumulation is implicated in plaque development. In contrast, VSMC apoptosis is implicated in plaque rupture, coagulation,…”
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Intracellular Interleukin-1 Receptor 2 Binding Prevents Cleavage and Activity of Interleukin-1α, Controlling Necrosis-Induced Sterile Inflammation by Zheng, Yue, Humphry, Melanie, Maguire, Janet J., Bennett, Martin R., Clarke, Murray C.H.

“…Necrosis can induce profound inflammation or be clinically silent. However, the mechanisms underlying such tissue specificity are unknown. Interleukin-1α…”
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Death Is Coming and the Clot Thickens, as Pyroptosis Feeds the Fire by Burzynski, Laura C., Clarke, Murray C.H.

“…Pyroptotic cell death during endotoxemia causes death via unknown mechanisms. In this issue of Immunity, Wu et al. (2019) show that T3SS rod proteins or LPS…”
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Smooth Muscle Cell Apoptosis Promotes Vessel Remodeling and Repair via Activation of Cell Migration, Proliferation, and Collagen Synthesis by Yu, Haixiang, Clarke, Murray C.H, Figg, Nichola, Littlewood, Trevor D, Bennett, Martin R

“…OBJECTIVE—Although vascular smooth muscle cell (VSMC) apoptosis occurs after vessel injury and during remodeling, the direct role of VSMC death in determining…”
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Killing the old: cell senescence in atherosclerosis by Bennett, Martin R, Clarke, Murray C H

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Cell surface IL‐1α trafficking is specifically inhibited by interferon‐γ, and associates with the membrane via IL‐1R2 and GPI anchors by Chan, Julie N.E., Humphry, Melanie, Kitt, Lauren, Krzyzanska, Dominika, Filbey, Kara J., Bennett, Martin R., Clarke, Murray C.H.

“…IL‐1 is a powerful cytokine that drives inflammation and modulates adaptive immunity. Both IL‐1α and IL‐1β are translated as proforms that require cleavage for…”
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Correction: Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia by Degryse, S., de Bock, C. E., Demeyer, S., Govaerts, I., Bornschein, S., Verbeke, D., Jacobs, K., Binos, S., Skerrett-Byrne, D. A., Murray, H. C., Verrills, N. M., Van Vlierberghe, P., Cools, J., Dun, M. D.

“…Following the publication of this article the authors noted that data describing precisely where phosphorylation sites in proteins modulated following JAK1 or…”
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Cigarette Smoke Prevents Apoptosis through Inhibition of Caspase Activation and Induces Necrosis by Wickenden, Julie A, Clarke, Murray C. H, Rossi, Adriano G, Rahman, Irfan, Faux, Stephen P, Donaldson, Kenneth, MacNee, William

“…Emphysema is characterized by enlargement of the distal airspaces in the lungs due to destruction of alveolar walls. Alveolar endothelial and epithelial cell…”
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Thrombin-activated interleukin-1α drives atherogenesis, but also promotes vascular smooth muscle cell proliferation and collagen production by Burzynski, Laura C, Morales-Maldonado, Alejandra, Rodgers, Amanda, Kitt, Lauren A, Humphry, Melanie, Figg, Nichola, Bennett, Martin R, Clarke, Murray C H

“…Abstract Aims Atherosclerosis is driven by multiple processes across multiple body systems. For example, the innate immune system drives both atherogenesis and…”
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Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia by Degryse, S, de Bock, C E, Demeyer, S, Govaerts, I, Bornschein, S, Verbeke, D, Jacobs, K, Binos, S, Skerrett-Byrne, D A, Murray, H C, Verrills, N M, Van Vlierberghe, P, Cools, J, Dun, M D

“…Mutations in the interleukin-7 receptor (IL7R) or the Janus kinase 3 (JAK3) kinase occur frequently in T-cell acute lymphoblastic leukemia (T-ALL) and both are…”
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Cell Death, Damage-Associated Molecular Patterns, and Sterile Inflammation in Cardiovascular Disease by Zheng, Yue, Gardner, Sarah E, Clarke, Murray C.H

“…Cell death and inflammation are ancient processes of fundamental biological importance in both normal physiology and pathology. This is evidenced by the…”
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Retrospective analysis of institutional scabies outbreaks from 1984 to 2013: lessons learned and moving forward by MOUNSEY, K. E., MURRAY, H. C., KING, M., OPRESCU, F.

“…Scabies outbreaks can be disruptive in institutional settings, and are associated with considerable but under-researched morbidity, especially in vulnerable…”
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