Search Results - "Murray, G. I."

The role of annexins in tumour development and progression by Mussunoor, S, Murray, GI

“…The annexins are a super‐family of closely related calcium and membrane‐binding proteins. They have a diverse range of cellular functions that include vesicle…”
Get full text

Characterisation and protein expression profiling of annexins in colorectal cancer by Duncan, R, Carpenter, B, Main, L C, Telfer, C, Murray, G I

“…The annexins are family of calcium-regulated phospholipid-binding proteins with diverse roles in cell biology. Individual annexins have been implicated in…”
Get full text

Prognostic value of lymph node ratio and extramural vascular invasion on survival for patients undergoing curative colon cancer resection by Parnaby, C N, Scott, N W, Ramsay, G, MacKay, C, Samuel, L, Murray, G I, Loudon, M A

“…Background: Increasing lymph node ratio (LNR) (ratio of metastatic lymph nodes to the total number of harvested lymph nodes) and extramural vascular invasion…”
Get full text

Heterogeneous nuclear ribonucleoprotein K is over expressed, aberrantly localised and is associated with poor prognosis in colorectal cancer by CARPENTER, B, MCKAY, M, DUNDAS, S. R, LAWRIE, L. C, TELFER, C, MURRAY, G. I

“…Heterogeneous ribonucleoprotein K (hnRNP K) is a member of the hnRNP family which has several different cellular roles including transcription, mRNA shuttling,…”
Get full text

Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas by Bain, G H, Collie-Duguid, E, Murray, G I, Gilbert, F J, Denison, A, Mckiddie, F, Ahearn, T, Fleming, I, Leeds, J, Phull, P, Park, K, Nanthakumaran, S, Grabsch, H I, Tan, P, Welch, A, Schweiger, L, Dahle-Smith, A, Urquhart, G, Finegan, M, Petty, R D

“…Background: Cytotoxic chemotherapy remains the main systemic therapy for gastro-oesophageal adenocarcinoma, but resistance to chemotherapy is common, resulting…”
Get full text

Matrix metalloproteinases: molecular aspects of their roles in tumour invasion and metastasis by Curran, S, Murray, G.I

“…The matrix metalloproteinases (MMPs) are a family of proteolytic enzymes, whose physiological functions include tissue remodelling and embryogenesis. The…”
Get full text

Expression of neutrophil gelatinase-associated lipocalin in colorectal neoplastic progression: a marker of malignant potential? by McLean, M H, Thomson, A J, Murray, G I, Fyfe, N, Hold, G L, El-Omar, E M

“…Background: Neutrophil gelatinase-associated lipocalin (NGAL) has a diverse functional repertoire, involved in the innate immune response as well as cell…”
Get full text

Matrix metalloproteinases in tumour invasion and metastasis by Curran, Stephanie, Murray, Graeme I.

“…The matrix metalloproteinases (MMPs) are a large family of proteolytic enzymes, which are involved in the degradation of many different components of the…”
Get full text

Influence of HPV type on prognosis in patients diagnosed with invasive cervical cancer by Cuschieri, K., Brewster, D.H., Graham, C., Nicoll, S., Williams, A.R.W., Murray, G.I., Millan, D., Johannessen, I., Hardie, A., Cubie, H.A.

“…While much is known about the influence of HPV type on the progression of pre‐invasive cervical lesions, the impact of HPV type on cervical cancer prognosis is…”
Get full text

Tumour markers of prognosis in colorectal cancer by MCLEOD, H. L, MURRAY, G. I

Get full text

Evaluation of the epidermal growth factor receptor (EGFR) in colorectal tumours and lymph node metastases by McKay, J.A, Murray, L.J, Curran, S, Ross, V.G, Clark, C, Murray, G.I, Cassidy, J, McLeod, H.L

“…Overexpression of the epidermal growth factor receptor (EGFR) often correlates with an aggressive tumour phenotype and poor prognosis. To examine the relevance…”
Get full text

Tumour cytochrome P450 and drug activation by Patterson, L H, Murray, G I

“…The expression of drug metabolising cytochrome P450s (CYPs) notably 1A, 1B, 2C, 3A, 2D subfamily members have been identified in a wide range of human cancers…”
Get more information

Liver fatty acid binding protein expression in colorectal neoplasia by LAWRIE, L. C, DUNDAS, S. R, CURRAN, S, MURRAY, G. I

“…Liver fatty acid binding protein is a member of the fatty acid binding group of proteins that are involved in the intracellular transport of bioactive fatty…”
Get full text

Characterization and over-expression of chaperonin t-complex proteins in colorectal cancer by Coghlin, C, Carpenter, B, Dundas, SR, Lawrie, LC, Telfer, C, Murray, GI

“…The chaperonins are key molecular complexes, which are essential in the folding of proteins to produce stable and functionally competent protein conformations…”
Get full text

Cytochrome P450 CYP1B1 activity in renal cell carcinoma by MCFADYEN, M. C. E, MELVIN, W. T, MURRAY, G. I

“…Renal cell carcinoma (RCC) is the most common malignancy of the kidney and has a poor prognosis due to its late presentation and resistance to current…”
Get full text

Matrix metalloproteinase 13 activity is associated with poor prognosis in colorectal cancer by Leeman, M F, McKay, J A, Murray, G I

“…Aims: The matrix metalloproteinases (MMPs) are a family of proteolytic enzymes collectively capable of degrading all extracellular matrix components, in…”
Get full text

Regulation, function, and tissue-specific expression of cytochrome P450 CYP1B1 by Murray, G I, Melvin, W T, Greenlee, W F, Burke, M D

“…Cytochrome P450 CYP1B1 is a relatively recently identified member of the CYP1 gene family. The purpose of this commentary is to review the regulatory…”
Get full text

Matrix metalloproteinases and their inhibitors in gastric cancer by Murray, G I, Duncan, M E, Arbuckle, E, Melvin, W T, Fothergill, J E

“…Background—The matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) are strongly implicated in tumour invasion and…”
Get full text

CYP3A4 and VDR gene polymorphisms and the risk of prostate cancer in men with benign prostate hyperplasia by TAYEB, M. T, CLARK, C, HAITES, N. E, SHARP, L, MURRAY, G. I, MCLEOD, H. L

“…Prostate cancer (PRCa) is one of the most common causes of cancer death in men and determinants of PRCa risk remain largely unidentified. Benign prostatic…”
Get full text

Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer by MCFADYEN, M. C. E, CRUICKSHANK, M. E, MILLER, I. D, MCLEOD, H. L, MELVIN, W. T, HAITES, N. E, PARKIN, D, MURRAY, G. I

“…Ovarian cancer is the most frequent cause of death from gynaecological malignancies world wide. Little improvement has been made in the long-term outcome of…”
Get full text