Search Results - "Murray, Evan"

Robust decomposition of cell type mixtures in spatial transcriptomics by Cable, Dylan M., Murray, Evan, Zou, Luli S., Goeva, Aleksandrina, Macosko, Evan Z., Chen, Fei, Irizarry, Rafael A.

“…A limitation of spatial transcriptomics technologies is that individual measurements may contain contributions from multiple cells, hindering the discovery of…”
Get full text

Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution by Rodriques, Samuel G, Stickels, Robert R, Goeva, Aleksandrina, Martin, Carly A, Murray, Evan, Vanderburg, Charles R, Welch, Joshua, Chen, Linlin M, Chen, Fei, Macosko, Evan Z

“…Spatial positions of cells in tissues strongly influence function, yet a high-throughput, genome-wide readout of gene expression with cellular resolution is…”
Get full text

In situ genome sequencing resolves DNA sequence and structure in intact biological samples by Payne, Andrew C, Chiang, Zachary D, Reginato, Paul L, Mangiameli, Sarah M, Murray, Evan M, Yao, Chun-Chen, Markoulaki, Styliani, Earl, Andrew S, Labade, Ajay S, Jaenisch, Rudolf, Church, George M, Boyden, Edward S, Buenrostro, Jason D, Chen, Fei

“…Understanding genome organization requires integration of DNA sequence and three-dimensional spatial context; however, existing genome-wide methods lack either…”
Get full text

Spatial genomics enables multi-modal study of clonal heterogeneity in tissues by Zhao, Tongtong, Chiang, Zachary D., Morriss, Julia W., LaFave, Lindsay M., Murray, Evan M., Del Priore, Isabella, Meli, Kevin, Lareau, Caleb A., Nadaf, Naeem M., Li, Jilong, Earl, Andrew S., Macosko, Evan Z., Jacks, Tyler, Buenrostro, Jason D., Chen, Fei

“…The state and behaviour of a cell can be influenced by both genetic and environmental factors. In particular, tumour progression is determined by underlying…”
Get full text

Stochastic electrotransport selectively enhances the transport of highly electromobile molecules by Kim, Sung-Yon, Cho, Jae Hun, Murray, Evan, Bakh, Naveed, Choi, Heejin, Ohn, Kimberly, Ruelas, Luzdary, Hubbert, Austin, McCue, Meg, Vassallo, Sara L., Keller, Philipp J., Chung, Kwanghun

“…Nondestructive chemical processing of porous samples such as fixed biological tissues typically relies on molecular diffusion. Diffusion into a porous…”
Get full text

Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex by Uzquiano, Ana, Kedaigle, Amanda J, Pigoni, Martina, Paulsen, Bruna, Adiconis, Xian, Kim, Kwanho, Faits, Tyler, Nagaraja, Surya, Antón-Bolaños, Noelia, Gerhardinger, Chiara, Tucewicz, Ashley, Murray, Evan, Jin, Xin, Buenrostro, Jason, Chen, Fei, Velasco, Silvia, Regev, Aviv, Levin, Joshua Z, Arlotta, Paola

“…Realizing the full utility of brain organoids to study human development requires understanding whether organoids precisely replicate endogenous cellular and…”
Get full text

Dissecting mammalian spermatogenesis using spatial transcriptomics by Chen, Haiqi, Murray, Evan, Sinha, Anubhav, Laumas, Anisha, Li, Jilong, Lesman, Daniel, Nie, Xichen, Hotaling, Jim, Guo, Jingtao, Cairns, Bradley R., Macosko, Evan Z., Cheng, C. Yan, Chen, Fei

“…Single-cell RNA sequencing has revealed extensive molecular diversity in gene programs governing mammalian spermatogenesis but fails to delineate their…”
Get full text

Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses by Hirz, Taghreed, Mei, Shenglin, Sarkar, Hirak, Kfoury, Youmna, Wu, Shulin, Verhoeven, Bronte M., Subtelny, Alexander O., Zlatev, Dimitar V., Wszolek, Matthew W., Salari, Keyan, Murray, Evan, Chen, Fei, Macosko, Evan Z., Wu, Chin-Lee, Scadden, David T., Dahl, Douglas M., Baryawno, Ninib, Saylor, Philip J., Kharchenko, Peter V., Sykes, David B.

“…The treatment of low-risk primary prostate cancer entails active surveillance only, while high-risk disease requires multimodal treatment including surgery,…”
Get full text

Physical Rehabilitation in Older Patients Hospitalized with Acute Heart Failure and Diabetes: Insights from REHAB-HF by Murray, Evan M., Whellan, David J., Chen, Haiying, Bertoni, Alain G., Duncan, Pamela, Pastva, Amy M., Kitzman, Dalane W., Mentz, Robert J.

“…Prior studies showed an attenuated response to exercise training among patients with heart failure and type 2 diabetes mellitus. We explored the interaction…”
Get full text

Detection of allele-specific expression in spatial transcriptomics with spASE by Zou, Luli S, Cable, Dylan M, Barrera-Lopez, Irving A, Zhao, Tongtong, Murray, Evan, Aryee, Martin J, Chen, Fei, Irizarry, Rafael A

“…Spatial transcriptomics technologies permit the study of the spatial distribution of RNA at near-single-cell resolution genome-wide. However, the feasibility…”
Get full text

Machine learning to define phenotypes and outcomes of patients hospitalized for heart failure with preserved ejection fraction: Findings from ASCEND-HF by Murray, Evan M., Greene, Stephen J., Rao, Vishal N., Sun, Jie-Lena, Alhanti, Brooke A., Blumer, Vanessa, Butler, Javed, Ahmad, Tariq, Mentz, Robert J.

“…Heart Failure with Preserved Ejection Fraction (HFpEF) is a heterogenous disease with few therapies proven to provide clinical benefit. Machine learning can…”
Get full text

In-Hospital Virtual Peer-to-Peer Consultation to Increase Guideline-Directed Medical Therapy for Heart Failure: A Pilot Randomized Trial by Rao, Vishal N., Shah, Anand, McDermott, Jaime, Barnes, Stephanie G., Murray, Evan M., Kelsey, Michelle D., Greene, Stephen J., Fudim, Marat, DeVore, Adam D., Patel, Chetan B., Blazing, Michael A., O’Brien, Cara, Mentz, Robert J.

“…Guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF) improves clinical outcomes and quality of life. Optimizing…”
Get full text

Spatial genomics enables multi-modal study of clonal heterogeneity in tissues by Zhao, Tongtong, Chiang, Zachary D., Morriss, Julia W., LaFave, Lindsay M., Murray, Evan M., Del Priore, Isabella, Meli, Kevin, Lareau, Caleb A., Nadaf, Naeem M., Li, Jilong, Earl, Andrew S., Macosko, Evan Z., Jacks, Tyler, Buenrostro, Jason D., Chen, Fei

Get full text

CD4+ T cells display a spectrum of recall dynamics during re-infection with malaria parasites by Lee, Hyun Jae, Moreira, Marcela L., Li, Shihan, Asatsuma, Takahiro, Williams, Cameron G., Skinner, Oliver P., Asad, Saba, Bramhall, Michael, Jiang, Zhe, Liu, Zihan, Kerr, Ashlyn S., Engel, Jessica A., Soon, Megan S. F., Straube, Jasmin, Barrera, Irving, Murray, Evan, Chen, Fei, Nideffer, Jason, Jagannathan, Prasanna, Haque, Ashraful

“…Children in malaria-endemic regions can experience repeated Plasmodium infections over short periods of time. Effects of re-infection on multiple co-existing…”
Get full text

Carbon emissions and air pollution savings among telehealth visits for cardiology appointments by Gunn, Alexander H., Murray, Evan M., Patel, Manesh R., Mentz, Robert J.

“…Climate change has been associated with adverse cardiovascular health, prompting interest in climate mitigation strategies while improving access for…”
Get full text

Plasmodium infection induces phenotypic, clonal, and spatial diversity among differentiating CD4+ T cells by Williams, Cameron G., Moreira, Marcela L., Asatsuma, Takahiro, Lee, Hyun Jae, Li, Shihan, Burn, Thomas N., Barrera, Irving, Murray, Evan, Soon, Megan S.F., Engel, Jessica A., Khoury, David S., Le, Shirley, Wanrooy, Brooke J., Schienstock, Dominick, Alexandre, Yannick O., Skinner, Oliver P., Joseph, Rainon, Beattie, Lynette, Mueller, Scott N., Chen, Fei, Haque, Ashraful

Get full text

Plasmodium infection induces phenotypic, clonal, and spatial diversity among differentiating CD4+ T cells by Williams, Cameron G., Moreira, Marcela L., Asatsuma, Takahiro, Lee, Hyun Jae, Li, Shihan, Burn, Thomas N., Barrera, Irving, Murray, Evan, Soon, Megan S.F., Engel, Jessica A., Khoury, David S., Le, Shirley, Wanrooy, Brooke J., Schienstock, Dominick, Alexandre, Yannick O., Skinner, Oliver P., Joseph, Rainon, Beattie, Lynette, Mueller, Scott N., Chen, Fei, Haque, Ashraful

“…Naive CD4+ T cells must differentiate in order to orchestrate immunity to Plasmodium, yet understanding of their emerging phenotypes, clonality, spatial…”
Get full text

The Role of Psychotic Disorders in Religious History Considered by Murray, Evan D, Cunningham, Miles G, Price, Bruce H

“…The authors have analyzed the religious figures Abraham, Moses, Jesus, and St. Paul from a behavioral, neurologic, and neuropsychiatric perspective to…”
Get full text

High-resolution Slide-seqV2 spatial transcriptomics enables discovery of disease-specific cell neighborhoods and pathways by Marshall, Jamie L., Noel, Teia, Wang, Qingbo S., Chen, Haiqi, Murray, Evan, Subramanian, Ayshwarya, Vernon, Katherine A., Bazua-Valenti, Silvana, Liguori, Katie, Keller, Keith, Stickels, Robert R., McBean, Breanna, Heneghan, Rowan M., Weins, Astrid, Macosko, Evan Z., Chen, Fei, Greka, Anna

“…High-resolution spatial transcriptomics enables mapping of RNA expression directly from intact tissue sections; however, its utility for the elucidation of…”
Get full text

Protecting the Health and Finances of the Elderly With Early Cognitive Impairment by Edersheim, Judith, Murray, Evan D, Padmanabhan, Jaya L, Price, Bruce H

“…The projected expansion of the nation's elderly population necessitates the revision of health care and policy strategies for safeguarding the health and…”
Get full text