Search Results - "Murr, Ashley S"

High-throughput screening and chemotype-enrichment analysis of ToxCast phase II chemicals evaluated for human sodium-iodide symporter (NIS) inhibition by Wang, Jun, Hallinger, Daniel R., Murr, Ashley S., Buckalew, Angela R., Lougee, Ryan R., Richard, Ann M., Laws, Susan C., Stoker, Tammy E.

“…In support of the Endocrine Disruptor Screening Program (EDSP), the U.S.EPA's Office of Research and Development (ORD) is developing high-throughput screening…”
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The rodent estrous cycle: characterization of vaginal cytology and its utility in toxicological studies by Goldman, Jerome M., Murr, Ashley S., Cooper, Ralph L.

“…While an evaluation of the estrous cycle in laboratory rodents can be a useful measure of the integrity of the hypothalamic‐pituitary‐ovarian reproductive…”
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The effects of prenatal exposure to atrazine on pubertal and postnatal reproductive indices in the female rat by Davis, Lori K., Murr, Ashley S., Best, Deborah S., Fraites, Melanie J.P., Zorrilla, Leah M., Narotsky, Michael G., Stoker, Tammy E., Goldman, Jerome M., Cooper, Ralph L.

“…Atrazine (ATR) is an herbicide that exerts negative reproductive effects. We examined the effects of vehicle or ATR (1, 5, 20 and 100 mg/kg-d), administered to…”
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High-Throughput Screening of ToxCast PFAS Chemical Library for Potential Inhibitors of the Human Sodium Iodide Symporter by Stoker, Tammy E., Wang, Jun, Murr, Ashley S., Bailey, Jarod R., Buckalew, Angela R.

“…Over the past decade, there has been increased concern for environmental chemicals that can target various sites within the hypothalamic–pituitary–thyroid axis…”
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High-Throughput Screening and Quantitative Chemical Ranking for Sodium-Iodide Symporter Inhibitors in ToxCast Phase I Chemical Library by Wang, Jun, Hallinger, Daniel R, Murr, Ashley S, Buckalew, Angela R, Simmons, Steven O, Laws, Susan C, Stoker, Tammy E

“…Thyroid uptake of iodide via the sodium-iodide symporter (NIS) is the first step in the biosynthesis of thyroid hormones that are critical for health and…”
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Evaluation of potential sodium-iodide symporter (NIS) inhibitors using a secondary Fischer rat thyroid follicular cell (FRTL-5) radioactive iodide uptake (RAIU) assay by Buckalew, Angela R., Wang, Jun, Murr, Ashley S., Deisenroth, Chad, Stewart, Wendy M., Stoker, Tammy E., Laws, Susan C.

“…The Fischer rat thyroid follicular cell line (FRTL-5) endogenously expresses the sodium-iodide symporter (NIS) and has been used to identify environmental…”
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Development of a screening approach to detect thyroid disrupting chemicals that inhibit the human sodium iodide symporter (NIS) by Hallinger, Daniel R., Murr, Ashley S., Buckalew, Angela R., Simmons, Steven O., Stoker, Tammy E., Laws, Susan C.

“…The U.S. EPA's Endocrine Disruptor Screening Program aims to use high-throughput assays and computational toxicology models to screen and prioritize chemicals…”
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An optimized radioimmunoassay for quantification of total serum thyroxine (T4) in fetal, neonatal, and pregnant rats by O'Shaughnessy, Katherine L., Hotchkiss, Michelle G., Buckalew, Angela K., Murr, Ashley S., Gilbert, Mary E., Stoker, Tammy E.

“…Identifying xenobiotics that interrupt the thyroid axis has significant public health implications, given that thyroid hormones are required for brain…”
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Expanded high-throughput screening and chemotype-enrichment analysis of the phase II: e1k ToxCast library for human sodium-iodide symporter (NIS) inhibition by Wang, Jun, Richard, Ann M., Murr, Ashley S., Buckalew, Angela R., Lougee, Ryan R., Shobair, Mahmoud, Hallinger, Daniel R., Laws, Susan C., Stoker, Tammy E.

“…The sodium-iodide symporter (NIS) mediates the uptake of iodide into the thyroid. Inhibition of NIS function by xenobiotics has been demonstrated to suppress…”
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Reproductive toxicity of a mixture of regulated drinking-water disinfection by-products in a multigenerational rat bioassay by Narotsky, Michael G, Klinefelter, Gary R, Goldman, Jerome M, DeAngelo, Anthony B, Best, Deborah S, McDonald, Anthony, Strader, Lillian F, Murr, Ashley S, Suarez, Juan D, George, Michael H, Hunter, E Sidney, Simmons, Jane Ellen

“…Trihalomethanes (THMs) and haloacetic acids (HAAs) are regulated disinfection by-products (DBPs); their joint reproductive toxicity in drinking water is…”
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Atrazine-induced elevation or attenuation of the LH surge in the ovariectomized, estrogen-primed female rat: role of adrenal progesterone by Goldman, Jerome M, Davis, Lori K, Murr, Ashley S, Cooper, Ralph L

“…Multiple exposures to the herbicide atrazine (ATRZ) were shown to suppress the LH surge in both cycling female rats and those ovariectomized (OVX) and primed…”
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Comprehensive Assessment of a Chlorinated Drinking Water Concentrate in a Rat Multigenerational Reproductive Toxicity Study by Narotsky, Michael G, Klinefelter, Gary R, Goldman, Jerome M, Best, Deborah S, McDonald, Anthony, Strader, Lillian F, Suarez, Juan D, Murr, Ashley S, Thillainadarajah, Inthirany, Hunter, E. Sidney, Richardson, Susan D, Speth, Thomas F, Miltner, Richard J, Pressman, Jonathan G, Teuschler, Linda K, Rice, Glenn E, Moser, Virginia C, Luebke, Robert W, Simmons, Jane Ellen

“…Some epidemiological studies report associations between drinking water disinfection byproducts (DBPs) and adverse reproductive/developmental effects, e.g.,…”
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Methoxychlor-induced alterations in the histological expression of angiogenic factors in pituitary and uterus by Goldman, Jerome M, Murr, Ashley S, Buckalew, Angela R, Schmid, Judith E, Abbott, Barbara D

“…Within the reproductive system, oestrogenic stimulation of uterine and pituitary tissue typically causes a proliferative response accompanied by an angiogenic…”
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Suppression of the Steroid-Primed Luteinizing Hormone Surge in the Female Rat by Sodium Dimethyldithiocarbamate: Relationship to Hypothalamic Catecholamines and GnRH Neuronal Activation by Goldman, Jerome M., Murr, Ashley S., Buckalew, Angela R., Cooper, Ralph L.

“…In female rodents, hypothalamic norepinephrine (NE) has a role in stimulating the secretion of gonadotropin-releasing hormone (GnRH) that triggers the…”
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Continuous Exposure to Dibromoacetic Acid Delays Pubertal Development and Compromises Sperm Quality in the Rat by Klinefelter, Gary R., Strader, Lillian F., Suarez, Juan D., Roberts, Naomi L., Goldman, Jerome M., Murr, Ashley S.

“…Previously our work on the haloacid by-products of drinking water disinfection focused on adult exposures. Herein we evaluate the consequence of continuous…”
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Reproductive functions and hypothalamic catecholamines in response to the soil fumigant metam sodium: Adaptations to extended exposures by Goldman, Jerome M, Cooper, Ralph L, Murr, Ashley S

“…Abstract Metam sodium (MS) is a soil fumigant and Category II pesticide with a relatively low toxicity in mammals. Previous data have shown an ability to…”
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Twenty-week exposures to the drinking water disinfection by-product dibromoacetic acid: reproductive cyclicity and steroid concentrations in the female Sprague–Dawley rat by Murr, Ashley S., Goldman, Jerome M.

“…Elevated gavage exposures to the drinking water disinfection by-product dibromoacetic acid (DBA) have been found to disrupt estrous cyclicity in the rat and…”
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Moderating influence of the drinking water disinfection by-product dibromoacetic acid on a dithiocarbamate-induced suppression of the luteinizing hormone surge in female rats by Goldman, Jerome M., Murr, Ashley S., Buckalew, Angela R., Ferrell, Janet M., Cooper, Ralph L.

“…The disinfection by-product dibromoacetic acid (DBA) has been found in female rats to increase circulating concentrations of both estradiol (E2) and estrone…”
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Alterations in ovarian follicular progesterone secretion by elevated exposures to the drinking water disinfection by-product dibromoacetic acid: examination of the potential site(s) of impact along the steroidogenic pathway by Goldman, Jerome M, Murr, Ashley S

“…Previous data from our laboratory indicated that the drinking water disinfection by-product, dibromoacetic acid (DBA), when applied in vitro to rat…”
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Dibromoacetic acid-induced elevations in circulating estradiol: effects in both cycling and ovariectomized/steroid-primed female rats by Goldman, Jerome M., Murr, Ashley S.

“…Oral exposures to high concentrations of the drinking water disinfection by-product dibromoacetic acid (DBA) over the course of 14 days have been found to…”
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