Search Results - "Murphy Jr, Greer M."

FKBP5 polymorphisms and antidepressant response in geriatric depression by Sarginson, Jane E., Lazzeroni, Laura C., Ryan, Heather S., Schatzberg, Alan F., Murphy Jr, Greer M.

“…Genetic variation at the FKBP5 locus has been reported to affect clinical outcomes in patients treated with antidepressant medications in several studies…”
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Markers in the 15q24 nicotinic receptor subunit gene cluster (CHRNA5-A3-B4) predict severity of nicotine addiction and response to smoking cessation therapy by Sarginson, Jane E., Killen, Joel D., Lazzeroni, Laura C., Fortmann, Stephen P., Ryan, Heather S., Schatzberg, Alan F., Murphy Jr, Greer M.

“…Stopping smoking is difficult even with treatment. Many patients prescribed pharmacologic treatments for smoking cessation experience side effects or lack of…”
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Pharmacogenetics of Antidepressant Medication Intolerance by Murphy, Greer M., Kremer, Charlotte, Rodrigues, Heidi E., Schatzberg, Alan F.

“…OBJECTIVE: The authors sought to identify genetic markers for antidepressant medication intolerance. Genetic variation in drug metabolizing enzymes such as…”
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Extended Treatment With Bupropion SR for Cigarette Smoking Cessation by Killen, Joel D, Fortmann, Stephen P, Murphy, Greer M, Hayward, Chris, Arredondo, Christina, Cromp, DeAnn, Celio, Maria, Abe, Laurie, Wang, Yun, Schatzberg, Alan F

“…The authors present results of a randomized clinical trial of the efficacy of extended treatment with bupropion SR in producing longer term cigarette smoking…”
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Failure to improve cigarette smoking abstinence with transdermal selegiline + cognitive behavior therapy by Killen, Joel D., Fortmann, Stephen P., Murphy Jr, Greer M., Hayward, Chris, Fong, Dalea, Lowenthal, Kimberly, Bryson, Susan W., Killen, Diana T., Schatzberg, Alan F.

“…ABSTRACT Aims  To examine the effectiveness of transdermal selegiline for producing cigarette smoking abstinence. Design  Adult smokers were randomly assigned…”
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Microglia Overexpressing the Macrophage Colony-Stimulating Factor Receptor Are Neuroprotective in a Microglial-Hippocampal Organotypic Coculture System by Mitrasinovic, Olivera M, Grattan, Alicia, Robinson, Christopher C, Lapustea, Nicolae B, Poon, Clara, Ryan, Heather, Phong, Connie, Murphy, Greer M., Jr

“…Microglia with increased expression of the macrophage colony-stimulating factor receptor (M-CSFR; c-fms) are found surrounding plaques in Alzheimer's disease…”
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Application of microarray technology in psychotropic drug trials by Murphy, Greer M.

“…Microarrays can be manufactured to detect hundreds of thousands of polymorphisms in DNA from patients in psychotropic drug trials. Some of these polymorphisms…”
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Analysis of neuronal gene expression with laser capture microdissection by Vincent, Valerie A.M., DeVoss, Jason J., Ryan, Heather S., Murphy Jr, Greer M.

“…The brain is a heterogeneous tissue in which the numbers of neurons, glia, and other cell types vary among anatomic regions. Gene expression studies performed…”
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Developing novel treatments for mood disorders: accelerating discovery by Tamminga, Carol A, Nemeroff, Charles B, Blakely, Randy D, Brady, Linda, Carter, Cameron S, Davis, Kenneth L, Dingledine, Raymond, Gorman, Jack M, Grigoriadis, Dimitri E, Henderson, David C, B. Innis, Robert, Killen, John, Laughren, Thomas P, McDonald, William M, M. Murphy, Greer, Paul, Steven M, Rudorfer, Matthew V, Sausville, Edward, Schatzberg, Alan F, Scolnick, Edward M, Suppes, Trisha

“…This review was generated from discussions by the Pharmacologic and Somatic Treatments Section of the National Institute of Mental Health Strategic Plan for…”
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Cardiac gene expression profile and lipid accumulation in response to starvation by Suzuki, Jinya, Shen, Wen-Jun, Nelson, Brett D, Selwood, Simon P, Murphy, Jr, Greer M, Kanehara, Hideo, Takahashi, Sadao, Oida, Koji, Miyamori, Isamu, Kraemer, Fredric B, Kanefara, Hideo

“…Starvation induces many biochemical and histological changes in the heart; however, the molecular events underlying these changes have not been fully…”
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Biolistic expression of the macrophage colony stimulating factor receptor in organotypic cultures induces an inflammatory response by Mitrasinovic, Olivera M., Robinson, Christopher C., Tenen, Daniel G., Lee, Yuen Ling, Poon, Clara, Murphy Jr, Greer M.

“…The receptor for macrophage colony‐stimulating factor (M‐CSFR; c‐fms) is expressed at increased levels by microglia in Alzheimer's disease (AD) and in mouse…”
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ABCB1 Genetic Effects on Antidepressant Outcomes: A Report From the iSPOT-D Trial by Schatzberg, Alan F., DeBattista, Charles, Lazzeroni, Laura C., Etkin, Amit, Murphy, Greer M., Williams, Leanne M.

“…Objective:The ABCB1 gene encodes P-glycoprotein, which limits brain concentrations of certain antidepressants. ABCB1 variation has been associated with…”
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Inflammation and the pathophysiology of Alzheimer's disease by Greer, M. Murphy Jr

“…There is increasing evidence that a chronic inflammatory response in the brain in Alzheimer's disease (AD) ultimately leads to neuronal injury and cognitive…”
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Pharmacogenetics of Psychotropic Drug Response by Malhotra, Anil K., Murphy, Greer M., Kennedy, James L.

“…OBJECTIVE: Molecular genetic approaches provide a novel method of dissecting the heterogeneity of psychotropic drug response. These pharmacogenetic strategies…”
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APOE-epsilon4 and aging of medial temporal lobe gray matter in healthy adults older than 50 years by Taylor, Joy L, Scanlon, Blake K, Farrell, Michelle, Hernandez, Beatriz, Adamson, Maheen M, Ashford, J. Wesson, Noda, Art, Murphy, Greer M, Weiner, Michael W

“…Abstract Atrophy of the hippocampus and surrounding temporal regions occurs in Alzheimer's disease (AD). APOE ε4, the major genetic risk factor for late-onset…”
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ABCB1 (MDR1) polymorphisms and antidepressant response in geriatric depression by Sarginson, Jane E, Lazzeroni, Laura C, Ryan, Heather S, Ershoff, Brent D, Schatzberg, Alan F, Murphy, Greer M

“…OBJECTIVEVariation in the ATP-binding cassette, subfamily B, member 1 transporter (ABCB1) (multidrug-resistance gene 1) gene has been investigated as a…”
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BDNF and CREB1 genetic variants interact to affect antidepressant treatment outcomes in geriatric depression by Murphy, Greer M, Sarginson, Jane E, Ryan, Heather S, O’Hara, Ruth, Schatzberg, Alan F, Lazzeroni, Laura C

“…AIMBrain-derived neurotrophic factor (BDNF) is associated with antidepressant response on the cellular level, in animal models, and in clinical studies. A…”
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Corticotropin-releasing factor 1 receptor haplotype and cognitive features of major depression by Davis, Elena Goetz, Keller, Jennifer, Hallmayer, Joachim, Pankow, Heather Ryan, Murphy, Greer M., Gotlib, Ian H., Schatzberg, Alan F.

“…Corticotropin-releasing factor signaling through CRF receptor type 1 (CRF 1 ) has been shown to contribute to learning and memory function. A haplotype of…”
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Response to Transdermal Selegiline Smoking Cessation Therapy and Markers in the 15q24 Chromosomal Region by Sarginson, Jane E., Killen, Joel D., Lazzeroni, Laura C., Fortmann, Stephen P., Ryan, Heather S., Ameli, Niloufar, Schatzberg, Alan F., Murphy, Greer M.

“…Current treatments for smoking cessation have limited efficacy. A potential pharmaceutical treatment for smoking cessation is selegiline, a selective and…”
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On the brain of a scientist: Albert Einstein by Diamond, M C, Scheibel, A B, Murphy, Jr, G M, Harvey, T

“…Neuron:glial ratios were determined in specific regions of Albert Einstein's cerebral cortex to compare with samples from 11 human male cortices. Cell counts…”
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