Search Results - "Murphy, Sean C"

Under the knife: Unfavorable perceptions of women who seek plastic surgery by Bonell, Sarah, Murphy, Sean C, Griffiths, Scott

“…Plastic surgery is growing in popularity. Despite this, there has been little exploration to date regarding the psychosocial consequences of seeking plastic…”
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Multi-step screening of DNA/lipid nanoparticles and co-delivery with siRNA to enhance and prolong gene expression by Zhu, Yining, Shen, Ruochen, Vuong, Ivan, Reynolds, Rebekah A., Shears, Melanie J., Yao, Zhi-Cheng, Hu, Yizong, Cho, Won June, Kong, Jiayuan, Reddy, Sashank K., Murphy, Sean C., Mao, Hai-Quan

“…Lipid nanoparticles hold great potential as an effective non-viral vector for nucleic acid-based gene therapy. Plasmid DNA delivery can result in extended…”
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Ethics of controlled human infection to address COVID-19 by Shah, Seema K, Miller, Franklin G, Darton, Thomas C, Duenas, Devan, Emerson, Claudia, Lynch, Holly Fernandez, Jamrozik, Euzebiusz, Jecker, Nancy S, Kamuya, Dorcas, Kapulu, Melissa, Kimmelman, Jonathan, MacKay, Douglas, Memoli, Matthew J, Murphy, Sean C, Palacios, Ricardo, Richie, Thomas L, Roestenberg, Meta, Saxena, Abha, Saylor, Katherine, Selgelid, Michael J, Vaswani, Vina, Rid, Annette

“…High social value is fundamental to justifying these studies Development of an effective vaccine is the clearest path to controlling the coronavirus disease…”
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Diesel and Crude Oil Biodegradation by Cold-Adapted Microbial Communities in the Labrador Sea by Murphy, Sean M C, Bautista, María A, Cramm, Margaret A, Hubert, Casey R J

“…Oil spills in the subarctic marine environment off the coast of Labrador, Canada, are increasingly likely due to potential oil production and increases in ship…”
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Using the Ultrasensitive Alere Plasmodium falciparum Malaria Ag HRP-2 ™ Rapid Diagnostic Test in the Field and Clinic in Northeastern Uganda by Owalla, Tonny Jimmy, Okurut, Emmanuel, Apungia, Gonzaga, Ojakol, Basil, Lema, Jimmy, C Murphy, Sean, G Egwang, Thomas

“…The ultrasensitive Alere Malaria Ag histidine-rich protein 2 rapid diagnostic test (Alere uRDT, Suwon City, South Korea) is a new diagnostic tool which is more…”
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Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity by Mwakingwe-Omari, Agnes, Healy, Sara A., Lane, Jacquelyn, Cook, David M., Kalhori, Sahand, Wyatt, Charles, Kolluri, Aarti, Marte-Salcedo, Omely, Imeru, Alemush, Nason, Martha, Ding, Lei K., Decederfelt, Hope, Duan, Junhui, Neal, Jillian, Raiten, Jacob, Lee, Grace, Hume, Jen C. C., Jeon, Jihyun E., Ikpeama, Ijeoma, KC, Natasha, Chakravarty, Sumana, Murshedkar, Tooba, Church, L. W. Preston, Manoj, Anita, Gunasekera, Anusha, Anderson, Charles, Murphy, Sean C., March, Sandra, Bhatia, Sangeeta N., James, Eric R., Billingsley, Peter F., Sim, B. Kim Lee, Richie, Thomas L., Zaidi, Irfan, Hoffman, Stephen L., Duffy, Patrick E.

“…The global decline in malaria has stalled 1 , emphasizing the need for vaccines that induce durable sterilizing immunity. Here we optimized regimens for…”
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Performance of a High-Sensitivity Rapid Diagnostic Test for Plasmodium falciparum Malaria in Asymptomatic Individuals from Uganda and Myanmar and Naive Human Challenge Infections by Das, Smita, Jang, Ihn Kyung, Barney, Becky, Peck, Roger, Rek, John C, Arinaitwe, Emmanuel, Adrama, Harriet, Murphy, Maxwell, Imwong, Mallika, Ling, Clare L, Proux, Stephane, Haohankhunnatham, Warat, Rist, Melissa, Seilie, Annette M, Hanron, Amelia, Daza, Glenda, Chang, Ming, Nakamura, Tomoka, Kalnoky, Michael, Labarre, Paul, Murphy, Sean C, McCarthy, James S, Nosten, Francois, Greenhouse, Bryan, Allauzen, Sophie, Domingo, Gonzalo J

“…Sensitive field-deployable diagnostic tests can assist malaria programs in achieving elimination. The performance of a new Alere™ Malaria Ag P.f Ultra…”
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The Cellular Basis of GABAB-Mediated Interhemispheric Inhibition by Palmer, Lucy M., Schulz, Jan M., Murphy, Sean C., Ledergerber, Debora, Murayama, Masanori, Larkum, Matthew E.

“…Interhemispheric inhibition is thought to mediate cortical rivalry between the two hemispheres through callosal input. The long-lasting form of this inhibition…”
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PfSPZ-CVac efficacy against malaria increases from 0% to 75% when administered in the absence of erythrocyte stage parasitemia: A randomized, placebo-controlled trial with controlled human malaria infection by Murphy, Sean C, Deye, Gregory A, Sim, B. Kim Lee, Galbiati, Shirley, Kennedy, Jessie K, Cohen, Kristen W, Chakravarty, Sumana, K. C., Natasha, Abebe, Yonas, James, Eric R, Kublin, James G, Hoffman, Stephen L, Richie, Thomas L, Jackson, Lisa A

“…PfSPZ-CVac combines ‘PfSPZ Challenge’, which consists of infectious Plasmodium falciparum sporozoites (PfSPZ), with concurrent antimalarial chemoprophylaxis…”
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Transcranial magnetic stimulation (TMS) inhibits cortical dendrites by Murphy, Sean C, Palmer, Lucy M, Nyffeler, Thomas, Müri, René M, Larkum, Matthew E

“…One of the leading approaches to non-invasively treat a variety of brain disorders is transcranial magnetic stimulation (TMS). However, despite its clinical…”
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Application of dried blood spot sample pooling strategies for Plasmodium 18S rRNA biomarker testing to facilitate identification of infected persons in large-scale epidemiological studies by Chang, Ming, Johnston, Selena, Seilie, Annette M, Hergott, Dianna, Murphy, Sean C

“…Plasmodium 18S rRNA is a sensitive biomarker for detecting Plasmodium infection in human blood. Dried blood spots (DBS) are a practical sample type for malaria…”
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Cocaine regulates sensory filtering in cortical pyramidal neurons by Murphy, Sean C., Godenzini, Luca, Guzulaitis, Robertas, Lawrence, Andrew J., Palmer, Lucy M.

“…Exposure to cocaine leads to robust changes in the structure and function of neurons within the mesocorticolimbic pathway. However, little is known about how…”
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A replication competent Plasmodium falciparum parasite completely attenuated by dual gene deletion by Goswami, Debashree, Patel, Hardik, Betz, William, Armstrong, Janna, Camargo, Nelly, Patil, Asha, Chakravarty, Sumana, Murphy, Sean C, Sim, B Kim Lee, Vaughan, Ashley M, Hoffman, Stephen L, Kappe, Stefan HI

“…Vaccination with infectious Plasmodium falciparum (Pf) sporozoites (SPZ) administered with antimalarial drugs (PfSPZ-CVac), confers superior sterilizing…”
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Reference and point-of-care testing for G6PD deficiency: Blood disorder interference, contrived specimens, and fingerstick equivalence and precision by Pal, Sampa, Myburgh, Jane, Bansil, Pooja, Hann, Amanda, Robertson, Lynn, Gerth-Guyette, Emily, Ambler, Gwen, Bizilj, Greg, Kahn, Maria, Zobrist, Stephanie, Manis, Michelle R, Styke, Nickolas A, Allan, Vajra, Ansbro, Richard, Akingbade, Tobi, Bryan, Andrew, Murphy, Sean C, Kublin, James G, Layton, Mark, Domingo, Gonzalo J

“…Certain clinical indications and treatments such as the use of rasburicase in cancer therapy and 8-aminoquinolines for Plasmodium vivax malaria treatment would…”
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Impact of six-month COVID-19 travel moratorium on Plasmodium falciparum prevalence on Bioko Island, Equatorial Guinea by Hergott, Dianna E. B., Guerra, Carlos A., García, Guillermo A., Mba Eyono, Jeremías Nzamío, Donfack, Olivier T., Iyanga, Marcos Mbulito, Nguema Avue, Restituto Mba, Abeso Nsegue, Crisantos Nsue, Ondo Mifumu, Teresa Ayingono, Rivas, Matilde Riloha, Phiri, Wonder P., Murphy, Sean C., Guthrie, Brandon L., Smith, David L., Balkus, Jennifer E.

“…Importation of malaria infections is a suspected driver of sustained malaria prevalence on areas of Bioko Island, Equatorial Guinea. Quantifying the impact of…”
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A Randomized Trial Evaluating the Prophylactic Activity of DSM265 Against Preerythrocytic Plasmodium falciparum Infection During Controlled Human Malarial Infection by Mosquito Bites and Direct Venous Inoculation by Murphy, Sean C, Duke, Elizabeth R, Shipman, Kelly J, Jensen, Ryan L, Fong, Youyi, Ferguson, Sue, Janes, Holly E, Gillespie, Kevin, Seilie, Annette M, Hanron, Amelia E, Rinn, Laurie, Fishbaugher, Matthew, VonGoedert, Tracie, Fritzen, Emma, Kappe, Stefan H, Chang, Ming, Sousa, Jason C, Marcsisin, Sean R, Chalon, Stephan, Duparc, Stephan, Kerr, Nicola, Möhrle, Jörg J, Andenmatten, Nicole, Rueckle, Thomas, Kublin, James G

“…Abstract Background DSM265 is a selective inhibitor of Plasmodium dihydroorotate dehydrogenase that fully protected against controlled human malarial infection…”
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Ultra-low volume intradermal administration of radiation-attenuated sporozoites with the glycolipid adjuvant 7DW8-5 completely protects mice against malaria by Watson, Felicia N., Shears, Melanie J., Kalata, Anya C., Duncombe, Caroline J., Seilie, A. Mariko, Chavtur, Chris, Conrad, Ethan, Cruz Talavera, Irene, Raappana, Andrew, Sather, D. Noah, Chakravarty, Sumana, Sim, B. Kim Lee, Hoffman, Stephen L., Tsuji, Moriya, Murphy, Sean C.

“…Radiation-attenuated sporozoite (RAS) vaccines can completely prevent blood stage Plasmodium infection by inducing liver-resident memory CD8 + T cells to…”
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Efficient infection of non-human primates with purified, cryopreserved Plasmodium knowlesi sporozoites by Chakravarty, Sumana, Shears, Melanie J, James, Eric R, Rai, Urvashi, KC, Natasha, Conteh, Solomon, Lambert, Lynn E, Duffy, Patrick E, Murphy, Sean C, Hoffman, Stephen L

“…Abstract Background Plasmodium falciparum (Pf) sporozoite (SPZ) vaccines are the only candidate malaria vaccines that induce > 90% vaccine efficacy (VE)…”
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Plasmodium knowlesi in pig-tailed macaques: a potential new model for malaria vaccine research by Shears, Melanie J, Reynolds, Rebekah A, Duncombe, Caroline J, Watson, Felicia N, Staubus, Weston J, Chavtur, Chris, Seilie, Annette M, Tran, Tuan M, Chakravarty, Sumana, Hoffman, Stephen L, Murphy, Sean C

“…Plasmodium knowlesi is an established experimental model for basic and pre-clinical malaria vaccine research. Historically, rhesus macaques have been the most…”
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Clinical performance validation of the STANDARD G6PD test: A multi-country pooled analysis by Adissu, Wondimagegn, Brito, Marcelo, Garbin, Eduardo, Macedo, Marcela, Monteiro, Wuelton, Mukherjee, Sandip Kumar, Myburg, Jane, Alam, Mohammad Shafiul, Bancone, Germana, Bansil, Pooja, Pal, Sampa, Sharma, Abhijit, Zobrist, Stephanie, Bryan, Andrew, Chu, Cindy S, Das, Santasabuj, Domingo, Gonzalo J, Hann, Amanda, Kublin, James, Lacerda, Marcus V G, Layton, Mark, Ley, Benedikt, Murphy, Sean C, Nosten, Francois, Pereira, Dhélio, Price, Ric N, Talukdar, Arunansu, Yilma, Daniel, Gerth-Guyette, Emily

“…Screening for G6PD deficiency can inform disease management including malaria. Treatment with the antimalarial drugs primaquine and tafenoquine can be guided…”
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