Search Results - "Murphy, Philip M."

Chemokines act as phosphatidylserine-bound "find-me" signals in apoptotic cell clearance by Pontejo, Sergio M, Murphy, Philip M

“…Removal of apoptotic cells is essential for maintenance of tissue homeostasis. Chemotactic cues termed "find-me" signals attract phagocytes toward apoptotic…”
Get full text

WHIM syndrome: Immunopathogenesis, treatment and cure strategies by McDermott, David H., Murphy, Philip M.

“…Summary WHIM syndrome is a rare, autosomal dominant immunodeficiency which is named for the four key manifestations: Warts, Hypogammaglobulinemia, Infections,…”
Get full text

Adaptive Immunodeficiency in WHIM Syndrome by Majumdar, Shamik, Murphy, Philip M

“…Cysteine-X-cysteine chemokine receptor 4 (CXCR4) is a broadly expressed and multifunctional G protein-coupled chemokine receptor critical for organogenesis,…”
Get full text

New nomenclature for atypical chemokine receptors by Bachelerie, Françoise, Graham, Gerard J, Locati, Massimo, Mantovani, Alberto, Murphy, Philip M, Nibbs, Robert, Rot, Antal, Sozzani, Silvano, Thelen, Marcus

Get full text

International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family by Ye, Richard D, Boulay, François, Wang, Ji Ming, Dahlgren, Claes, Gerard, Craig, Parmentier, Marc, Serhan, Charles N, Murphy, Philip M

“…Formyl peptide receptors (FPRs) are a small group of seven-transmembrane domain, G protein-coupled receptors that are expressed mainly by mammalian phagocytic…”
Get full text

Chemokines encoded by herpesviruses by Pontejo, Sergio M., Murphy, Philip M.

“…Review on viral chemokine homologues identified in Herpesviridae family, their implications in viral pathogenesis and leukocyte migration, and their potential…”
Get full text

Chemokine Regulation During Epidemic Coronavirus Infection by Majumdar, Shamik, Murphy, Philip M

“…SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus-2) is the third coronavirus to emerge as a cause of severe and frequently fatal pneumonia epidemics…”
Get full text

Hematopoietic chimerism and donor-specific skin allograft tolerance after non-genotoxic CD117 antibody-drug-conjugate conditioning in MHC-mismatched allotransplantation by Li, Zhanzhuo, Czechowicz, Agnieszka, Scheck, Amelia, Rossi, Derrick J., Murphy, Philip M.

“…Hematopoietic chimerism after allogeneic bone marrow transplantation may establish a state of donor antigen-specific tolerance. However, current…”
Get full text

Chemokine Receptor CX3CR1 Mediates Skin Wound Healing by Promoting Macrophage and Fibroblast Accumulation and Function by Ishida, Yuko, Gao, Ji-Liang, Murphy, Philip M

“…Wounds heal through a highly regulated, self-limited inflammatory response, however, precise inflammatory mediators have not been fully delineated. In this…”
Get full text

Intraluminal Containment of Commensal Outgrowth in the Gut during Infection-Induced Dysbiosis by Molloy, Michael J., Grainger, John R., Bouladoux, Nicolas, Hand, Timothy W., Koo, Lily Y., Naik, Shruti, Quinones, Mariam, Dzutsev, Amiran K., Gao, Ji-Liang, Trinchieri, Giorgio, Murphy, Philip M., Belkaid, Yasmine

“…Shifts in commensal microbiota composition are emerging as a hallmark of gastrointestinal inflammation. In particular, outgrowth of γ-proteobacteria has been…”
Get full text

Plerixafor for the Treatment of WHIM Syndrome by McDermott, David H, Pastrana, Diana V, Calvo, Katherine R, Pittaluga, Stefania, Velez, Daniel, Cho, Elena, Liu, Qian, Trout, Hugh H, Neves, João F, Gardner, Pamela J, Bianchi, David A, Blair, Elizabeth A, Landon, Emily M, Silva, Susana L, Buck, Christopher B, Murphy, Philip M

“…WHIM syndrome (warts, hypogammaglobulinemia, infections, and myelokathexis) results from hyperactivity of the chemokine receptor CXCR4. Plerixafor blocks the…”
Get full text

Chromothriptic Cure of WHIM Syndrome by McDermott, David H., Gao, Ji-Liang, Liu, Qian, Siwicki, Marie, Martens, Craig, Jacobs, Paejonette, Velez, Daniel, Yim, Erin, Bryke, Christine R., Hsu, Nancy, Dai, Zunyan, Marquesen, Martha M., Stregevsky, Elina, Kwatemaa, Nana, Theobald, Narda, Long Priel, Debra A., Pittaluga, Stefania, Raffeld, Mark A., Calvo, Katherine R., Maric, Irina, Desmond, Ronan, Holmes, Kevin L., Kuhns, Douglas B., Balabanian, Karl, Bachelerie, Françoise, Porcella, Stephen F., Malech, Harry L., Murphy, Philip M.

“…Chromothripsis is a catastrophic cellular event recently described in cancer in which chromosomes undergo massive deletion and rearrangement. Here, we report a…”
Get full text

Chemokine regulation of atherosclerosis by Barlic, Jana, Murphy, Philip M.

“…Oxidative stress and inflammation are accepted as major factors in the pathogenesis of atherosclerosis, but how they interact to produce a plaque has not been…”
Get full text

Organ-Specific Innate Immune Responses in a Mouse Model of Invasive Candidiasis by Lionakis, Michail S., Lim, Jean K., Lee, Chyi-Chia Richard, Murphy, Philip M.

“…In a fatal mouse model of invasive candidiasis (IC), fungal burden changes with variable dynamics in the kidney, brain, spleen, and liver and declines in all…”
Get full text

The Macrophage-depleting Agent Clodronate Promotes Durable Hematopoietic Chimerism and Donor-specific Skin Allograft Tolerance in Mice by Li, Zhanzhuo, Xu, Xin, Feng, Xingmin, Murphy, Philip M.

“…Hematopoietic chimerism is known to promote donor-specific organ allograft tolerance; however, clinical translation has been impeded by the requirement for…”
Get full text

Complete Genome Sequence of a Tenth Human Polyomavirus by BUCK, Christopher B, PHAN, Giao Q, RAIJI, Manish T, MURPHY, Philip M, MCDERMOTT, David H, MCBRIDE, Alison A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

CXCR4 antagonist AMD3100 redistributes leukocytes from primary immune organs to secondary immune organs, lung, and blood in mice by Liu, Qian, Li, Zhanzhuo, Gao, Ji‐Liang, Wan, Wuzhou, Ganesan, Sundar, McDermott, David H., Murphy, Philip M.

“…AMD3100 (plerixafor), is a specific CXCR4 antagonist approved by the FDA for mobilizing hematopoietic stem cells from bone marrow to blood for transplantation…”
Get full text

NF kappa B regulator Bcl3 controls development and function of classical dendritic cells required for resistance to Toxoplasma gondii by Guha, June, Kang, Byunghyun, Claudio, Estefania, Redekar, Neelam R, Wang, Hongshan, Kelsall, Brian L, Siebenlist, Ulrich, Murphy, Philip M

“…The atypical IκB family member Bcl3 associates with p50/NF-κB1 or p52/NF-κB2 homodimers in the nucleus, and positively or negatively modulates transcription in…”
Get full text

Chemokine receptor Ccr1 drives neutrophil-mediated kidney immunopathology and mortality in invasive candidiasis by Lionakis, Michail S, Fischer, Brett G, Lim, Jean K, Swamydas, Muthulekha, Wan, Wuzhou, Richard Lee, Chyi-Chia, Cohen, Jeffrey I, Scheinberg, Phillip, Gao, Ji-Liang, Murphy, Philip M

“…Invasive candidiasis is the 4(th) leading cause of nosocomial bloodstream infection in the US with mortality that exceeds 40% despite administration of…”
Get full text

A phase III randomized crossover trial of plerixafor versus G-CSF for treatment of WHIM syndrome by McDermott, David H, Velez, Daniel, Cho, Elena, Cowen, Edward W, DiGiovanna, John J, Pastrana, Diana V, Buck, Christopher B, Calvo, Katherine R, Gardner, Pamela J, Rosenzweig, Sergio D, Stratton, Pamela, Merideth, Melissa A, Kim, H Jeffrey, Brewer, Carmen, Katz, James D, Kuhns, Douglas B, Malech, Harry L, Follmann, Dean, Fay, Michael P, Murphy, Philip M

“…BACKGROUNDWarts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a primary immunodeficiency disorder caused by heterozygous…”
Get full text