Search Results - "Murphy, Maureen E"

The role of the p53 tumor suppressor in metabolism and diabetes by Kung, Che-Pei, Murphy, Maureen E

“…In the context of tumor suppression, p53 is an undisputedly critical protein. Functioning primarily as a transcription factor, p53 helps fend off the…”
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Fatty acid transport protein 2 reprograms neutrophils in cancer by Veglia, Filippo, Tyurin, Vladimir A., Blasi, Maria, De Leo, Alessandra, Kossenkov, Andrew V., Donthireddy, Laxminarasimha, To, Tsun Ki Jerrick, Schug, Zach, Basu, Subhasree, Wang, Fang, Ricciotti, Emanuela, DiRusso, Concetta, Murphy, Maureen E., Vonderheide, Robert H., Lieberman, Paul M., Mulligan, Charles, Nam, Brian, Hockstein, Neil, Masters, Gregory, Guarino, Michael, Lin, Cindy, Nefedova, Yulia, Black, Paul, Kagan, Valerian E., Gabrilovich, Dmitry I.

“…Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) are pathologically activated neutrophils that are crucial for the regulation of immune responses…”
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Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease by Stockwell, Brent R., Friedmann Angeli, José Pedro, Bayir, Hülya, Bush, Ashley I., Conrad, Marcus, Dixon, Scott J., Fulda, Simone, Gascón, Sergio, Hatzios, Stavroula K., Kagan, Valerian E., Noel, Kay, Jiang, Xuejun, Linkermann, Andreas, Murphy, Maureen E., Overholtzer, Michael, Oyagi, Atsushi, Pagnussat, Gabriela C., Park, Jason, Ran, Qitao, Rosenfeld, Craig S., Salnikow, Konstantin, Tang, Daolin, Torti, Frank M., Torti, Suzy V., Toyokuni, Shinya, Woerpel, K.A., Zhang, Donna D.

“…Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Emerging evidence…”
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Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53 by Leu, Julia I-Ju, Murphy, Maureen E., George, Donna L.

“…A population-restricted single-nucleotide coding region polymorphism (SNP) at codon 47 exists in the human TP53 gene (P47S, hereafter P47 and S47). In studies…”
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Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer by Veglia, Filippo, Tyurin, Vladimir A., Mohammadyani, Dariush, Blasi, Maria, Duperret, Elizabeth K., Donthireddy, Laxminarasimha, Hashimoto, Ayumi, Kapralov, Alexandr, Amoscato, Andrew, Angelini, Roberto, Patel, Sima, Alicea-Torres, Kevin, Weiner, David, Murphy, Maureen E., Klein-Seetharaman, Judith, Celis, Esteban, Kagan, Valerian E., Gabrilovich, Dmitry I.

“…Cross-presentation is a critical function of dendritic cells (DCs) required for induction of antitumor immune responses and success of cancer immunotherapy. It…”
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The p53 Tumor Suppressor in the Control of Metabolism and Ferroptosis by Gnanapradeepan, Keerthana, Basu, Subhasree, Barnoud, Thibaut, Budina-Kolomets, Anna, Kung, Che-Pei, Murphy, Maureen E

“…The p53 tumor suppressor continues to be distinguished as the most frequently mutated gene in human cancer. It is widely believed that the ability of p53 to…”
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Shifting the paradigms for tumor suppression: lessons from the p53 field by Barnoud, Thibaut, Indeglia, Alexandra, Murphy, Maureen E.

“…The TP53 gene continues to hold distinction as the most frequently mutated gene in cancer. Since its discovery in 1979, hundreds of research groups have…”
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A Small Molecule Inhibitor of Inducible Heat Shock Protein 70 by Leu, J. I-Ju, Pimkina, Julia, Frank, Amanda, Murphy, Maureen E., George, Donna L.

“…The multifunctional, stress-inducible molecular chaperone HSP70 has important roles in aiding protein folding and maintaining protein homeostasis. HSP70…”
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An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model by Jennis, Matthew, Kung, Che-Pei, Basu, Subhasree, Budina-Kolomets, Anna, Leu, Julia I-Ju, Khaku, Sakina, Scott, Jeremy P, Cai, Kathy Q, Campbell, Michelle R, Porter, Devin K, Wang, Xuting, Bell, Douglas A, Li, Xiaoxian, Garlick, David S, Liu, Qin, Hollstein, Monica, George, Donna L, Murphy, Maureen E

“…A nonsynonymous single-nucleotide polymorphism at codon 47 in TP53 exists in African-descent populations (P47S, rs1800371; referred to here as S47). Here we…”
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The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction by Kung, Che-Pei, Leu, Julia I-Ju, Basu, Subhasree, Khaku, Sakina, Anokye-Danso, Frederick, Liu, Qin, George, Donna L., Ahima, Rexford S., Murphy, Maureen E.

“…p53 is well known for its tumor suppressor role, but this protein also has a poorly understood role in the regulation of metabolism. Human studies have…”
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Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrate by Zhang, Pingfeng, Leu, Julia I-Ju, Murphy, Maureen E, George, Donna L, Marmorstein, Ronen

“…The HSP70 family of molecular chaperones function to maintain protein quality control and homeostasis. The major stress-induced form, HSP70 (also called HSP72…”
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African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin by Singh, Kumar Sachin, Leu, Julia I-Ju, Barnoud, Thibaut, Vonteddu, Prashanthi, Gnanapradeepan, Keerthana, Lin, Cindy, Liu, Qin, Barton, James C., Kossenkov, Andrew V., George, Donna L., Murphy, Maureen E., Dotiwala, Farokh

“…A variant at amino acid 47 in human TP53 exists predominantly in individuals of African descent. P47S human and mouse cells show increased cancer risk due to…”
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HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells by Leu, J I-Ju, Pimkina, Julia, Pandey, Pooja, Murphy, Maureen E, George, Donna L

“…The evolutionarily conserved stress-inducible HSP70 molecular chaperone plays a central role in maintaining protein quality control in response to various…”
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p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression by Xu, Yang, Lin, Tongxiang, Chao, Connie, Saito, Shin'ichi, Mazur, Sharlyn J, Murphy, Maureen E, Appella, Ettore

“…The tumour suppressor p53 becomes activated in response to upstream stress signals, such as DNA damage, and causes cell-cycle arrest or apoptosis. Here we…”
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Editorial: Double-edged swords: important factors connecting metabolic disorders and cancer development - from basic research to translational applications, volume II by Kung, Che-Pei, Barnoud, Thibaut, Yao, Cong-Hui, Bertolini, Irene, Murphy, Maureen E

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Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C‑Terminal Allosteric Pocket by Leu, Julia I-Ju, Zhang, Pingfeng, Murphy, Maureen E., Marmorstein, Ronen, George, Donna L.

“…The stress-inducible mammalian heat shock protein 70 (HSP70) and its bacterial orthologue DnaK are highly conserved nucleotide binding molecular chaperones…”
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Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex by George, Donna L, Leu, J. I-Ju, Dumont, Patrick, Hafey, Michael, Murphy, Maureen E

“…The tumour suppressor activity of the p53 protein has been explained by its ability to induce apoptosis in response to a variety of cellular stresses. Thus,…”
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Mutant p53 regulates Survivin to foster lung metastasis by Tang, Qiaosi, Efe, Gizem, Chiarella, Anna M, Leung, Jessica, Chen, Maoting, Yamazoe, Taiji, Su, Zhenyi, Pitarresi, Jason R, Li, Jinyang, Islam, Mirazul, Karakasheva, Tatiana, Klein-Szanto, Andres J, Pan, Samuel, Hu, Jianhua, Natsugoe, Shoji, Gu, Wei, Stanger, Ben Z, Wong, Kwok-K, Diehl, J Alan, Bass, Adam J, Nakagawa, Hiroshi, Murphy, Maureen E, Rustgi, Anil K

“…Esophageal squamous cell carcinoma (ESCC) is one of the most lethal cancers worldwide and evolves often to lung metastasis. (homologous to in mice) is a common…”
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Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans by Kang, Hey-Joo, Feng, Zhaohui, Sun, Yvonne, Atwal, Gurinder, Murphy, Maureen E, Rebbeck, Timothy R, Rosenwaks, Zev, Levine, Arnold J, Hu, Wenwei

“…The tumor suppressor protein p53 plays an important role in maternal reproduction in mice through transcriptional regulation of leukemia inhibitory factor…”
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A Novel Inhibitor of HSP70 Induces Mitochondrial Toxicity and Immune Cell Recruitment in Tumors by Barnoud, Thibaut, Leung, Jessica C, Leu, Julia I-Ju, Basu, Subhasree, Poli, Adi Narayana Reddy, Parris, Joshua L D, Indeglia, Alexandra, Martynyuk, Tetyana, Good, Madeline, Gnanapradeepan, Keerthana, Sanseviero, Emilio, Moeller, Rebecca, Tang, Hsin-Yao, Cassel, Joel, Kossenkov, Andrew V, Liu, Qin, Speicher, David W, Gabrilovich, Dmitry I, Salvino, Joseph M, George, Donna L, Murphy, Maureen E

“…The protein chaperone HSP70 is overexpressed in many cancers including colorectal cancer, where overexpression is associated with poor survival. We report here…”
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