Search Results - "Murphy, M.P"

Increased fragmentation of sleep–wake cycles in the 5XFAD mouse model of Alzheimer’s disease by Sethi, M, Joshi, S.S, Webb, R.L, Beckett, T.L, Donohue, K.D, Murphy, M.P, O’Hara, B.F, Duncan, M.J

“…Highlights • AD patients have disturbed sleep, including increased sleep fragmentation. • Sleep and wake patterns in 5XFAD mice, a model of AD, were examined…”
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Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease by Platt, T.L, Beckett, T.L, Kohler, K, Niedowicz, D.M, Murphy, M.P

“…Highlights • Obesity, diabetes, and leptin resistance promote tau phosphorylation in vivo. • Leptin resistance promotes tau phosphorylation in vitro. •…”
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Waalbot: An Agile Small-Scale Wall-Climbing Robot Utilizing Dry Elastomer Adhesives by Murphy, M.P., Sitti, M.

“…This paper proposes a small-scale agile wall-climbing robot, which is able to climb on smooth vertical surfaces using flat adhesive elastomer materials for…”
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Evaluation of Cell Therapy on Exercise Performance and Limb Perfusion in Peripheral Artery Disease: The CCTRN Patients with Intermittent Claudication Injected with ALDH Bright Cells (PACE) Trial by Perin, E.C, Murphy, M.P, March, K.L, Bolli, R, Loughran, J, Yang, P.C

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G10 : Mitochondrial-targeted antioxidant mitoquinone reduces portal hypertension in CCL4-cirrhotic rats by decreasing intrahepatic resistance by Vilaseca Barceló, M, López-Sanjurjo, C, Murphy, M.P, Bosch, J, Hernández-Gea, V, Gracia-Sancho, J, García-Pagán, J.C

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Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species and correlates with higher risk plaques in humans by Yu, E, Calvert, P.A, Mercer, J.R, Harrison, J, Baker, L, Figg, N, Kumar, S, Wang, J, Hurst, L, Obaid, D.R, Logan, A, West, N.E.J, Clarke, M.C.H, Vidal-Puig, A, Murphy, M.P, Bennett, M.R

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847 PHASE II STUDY OF THE MITOCHONDRIAL ANTIOXIDANT MITOQUINONE FOR HEPATITIS C by Gane, E.J, Orr, D.W, Weilert, F, Keogh, G.F, Gibson, M, Murphy, M.P, Smith, R.A, Lockhart, M.M, Frampton, C.M, Taylor, K.M

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Dog Bites And Vascular Injury: A Retrospective Review From A Level I Trauma Center by Rapp, B.M, Tsai, A, Jester, A.L, Fajardo, A, Lemmon, G.W, Motaganahalli, R.L, Akingba, G, Sawchuk, A.P, Cikrit, D.F, Dalsing, M.C, Murphy, M.P

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QS244. Greater Saphenous Vein is an Abundant Source of Endothelial Progenitor Cells by Ofstein, R, Bhavsar, J, Moreno, O, Saadatzadeh, R, Dalsing, M.C, Murphy, M.P

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Mitochondria-targeted antioxidants: A therapeutic strategy by Murphy⁎, M.P.

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P2-389: Metabolic treatments for Alzheimer's disease by Costantini, Lauren C, Studzinski, C.M, Araujo, J.A, MacKay, W.A, Webb, R.L, Beckett, T.L, Murphy, M.P, Sullivan, P.G, Burnham, W.M, Milgram, N.W, Vogel, J, Barr, L, Henderson, S.T

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Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis by Lowes, D.A., Webster, N.R., Murphy, M.P., Galley, H.F.

“…Sepsis-induced organ failure is the major cause of death in critical care units, and is characterized by a massive dysregulated inflammatory response and…”
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Synthesis and Characterization of Thiobutyltriphenylphosphonium Bromide, a Novel Thiol Reagent Targeted to the Mitochondrial Matrix by Burns, R.J., Smith, R.A.J., Murphy, M.P.

“…Mitochondria are continually exposed to oxidative stress due to superoxide formation by the respiratory chain which increases in pathological situations such…”
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Protein carbonyl formation and tyrosine nitration as markers of oxidative damage during ischaemia-reperfusion injury to rat sciatic nerve by He, K., Nukada, H., McMorran, P.D., Murphy, M.P.

“…We have investigated the role of oxidative damage in peripheral nerve ischaemia-reperfusion injury using a rat sciatic nerve model. After 5 h ischaemia blood…”
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WS18.02 ETI triple therapy shows sustained, progressive normalisation of airway cytokine and antiprotease balance and systemic inflammation over one year of treatment by Murphy, M.P., Casey, M., Gabillard-Lefort, C., McElvaney, O.F., McElvaney, O.J., Carroll, T.P., Gunaratnam, C., McElvaney, N.G.

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Chronic Fragmentation of the Daily Sleep-Wake Rhythm Increases Amyloid-beta Levels and Neuroinflammation in the 3xTg-AD Mouse Model of Alzheimer’s Disease by Duncan, M.J., Guerriero, L.E., Kohler, K., Beechem, L.E., Gillis, B.D., Salisbury, F., Wessel, C., Wang, J., Sunderam, S., Bachstetter, A.D., O'Hara, B.F., Murphy, M.P.

“…•Four daily bouts of exposure to novelty and gentle stimulation fragment the daily sleep-wake rhythm in female 3xTg-AD mice.•Chronic fragmentation of the daily…”
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The role of Mitochondrial Superoxide Release in Acute and Chronic Hypoxia Sensing and Signaling of the Pulmonary vasculature by Pak, Oleg, Hüttemann, M., Scheibe, S., Gierhardt, M., Sydykov, A., Schäfer, K., Ghofrani, H.A., Schermuly, R.T., Murphy, M.P., Grossman, L.I., Weissmann, N., Sommer, N.

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In vivo evidence of mitochondrial dysfunction and altered redox homeostasis in a genetic mouse model of propionic acidemia: Implications for the pathophysiology of this disorder by Gallego-Villar, L., Rivera-Barahona, A., Cuevas-Martín, C., Guenzel, A., Pérez, B., Barry, M.A., Murphy, M.P., Logan, A., Gonzalez-Quintana, A., Martín, M.A., Medina, S., Gil-Izquierdo, A., Cuezva, J.M., Richard, E., Desviat, L.R.

“…Accumulation of toxic metabolites has been described to inhibit mitochondrial enzymes, thereby inducing oxidative stress in propionic acidemia (PA), an…”
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Investigating real-time metabolic flux changes in a rat model of doxorubicin-induced cardiotoxicity using hyperpolarized 13C magnetic resonance spectroscopy by Timm, K.N., Perera, C.A., Ball, V., Henry, J.A., West, J.A., Kerr, M., Logan, A., Griffin, J.L., Murphy, M.P., Heather, L.C., Tyler, D.J.

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A Simple and Rapid Test of Sensorimotor Function in the Aged Rat by Murphy, M.P., Rick, J.T., Milgram, N.W., Ivy, G.O.

“…A total of 107 Fischer 344 rats (male and female, 2 to 29 months old) were tested on three tasks designed to measure sensorimotor function. In the first task,…”
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