Search Results - "Murphy, L C"

Lithium in patients with amyotrophic lateral sclerosis (LiCALS): a phase 3 multicentre, randomised, double-blind, placebo-controlled trial by Morrison, K E, Dhariwal, S, Hornabrook, R, Savage, L, Burn, D J, Khoo, T K, Kelly, J, Murphy, C L, Al-Chalabi, A, Dougherty, A, Leigh, P N, Wijesekera, L, Thornhill, M, Ellis, C M, O'Hanlon, K, Panicker, J, Pate, L, Ray, P, Wyatt, L, Young, C A, Copeland, L, Ealing, J, Hamdalla, H, Leroi, I, Murphy, C, O'Keeffe, F, Oughton, E, Partington, L, Paterson, P, Rog, D, Sathish, A, Sexton, D, Smith, J, Vanek, H, Dodds, S, Williams, T L, Steen, I N, Clarke, J, Eziefula, C, Howard, R, Orrell, R, Sidle, K, Sylvester, R, Barrett, W, Merritt, C, Talbot, K, Turner, M R, Whatley, C, Williams, C, Williams, J, Cosby, C, Hanemann, C O, Iman, I, Philips, C, Timings, L, Crawford, S E, Hewamadduma, C, Hibberd, R, Hollinger, H, McDermott, C, Mils, G, Rafiq, M, Shaw, P J, Taylor, A, Waines, E, Walsh, T, Addison-Jones, R, Birt, J, Hare, M, Majid, T

“…Summary Background Lithium has neuroprotective effects in cell and animal models of amyotrophic lateral sclerosis (ALS), and a small pilot study in patients…”
Get full text

Mapping the colorectal tumor microbiota by Murphy, CL, Barrett, M, Pellanda, P, Killeen, S, McCourt, M, Andrews, E, O’ Riordain, M, Shanahan, F, O’Toole, Pw

“…The gut microbiome in patients with colorectal cancer (CRC) is different than that of healthy controls. Previous studies have profiled the CRC tumor microbiome…”
Get full text

Expression of both Estrogen Receptor-beta 1 (ER-β1) and its co-regulator Steroid Receptor RNA Activator Protein (SRAP) are predictive for benefit from tamoxifen therapy in patients with Estrogen Receptor-alpha (ER-α)-Negative Early Breast Cancer (EBC) by Yan, Y., Li, X., Blanchard, A., Bramwell, V.H.C., Pritchard, K.I., Tu, D., Shepherd, L., Myal, Y., Penner, C., Watson, P.H., Leygue, E., Murphy, L.C.

“…Roles of Estrogen Receptor-beta 1 (ER-β1) and its co-regulator Steroid Receptor RNA Activator Protein (SRAP) in breast cancer remain unclear. Previously, ER-β1…”
Get full text

Expression of oestrogen receptor-β in oestrogen receptor-α negative human breast tumours by SKLIRIS, G. P, LEYGUE, E, CURTIS-SNELL, L, WATSON, P. H, MURPHY, L. C

“…To analyse the phenotype of breast tumours that express oestrogen receptor-beta (ERbeta) alone tissue microarrays were used to investigate if ERbeta isoforms…”
Get full text

Putative functional characteristics of human estrogen receptor-beta isoforms by Peng, B, Lu, B, Leygue, E, Murphy, LC

“…Estrogen receptors (ERalpha and ERbeta) are clearly multifaceted in terms of structure and function. Several relatively abundant ERbeta isoforms have been…”
Get full text

Faecal microbiota transplantation (FMT): classical bedside-to-bench clinical research by Murphy, C L, Zulquernain, S A, Shanahan, F

Get full text

Immunohistochemical and Biochemical Evidence of Ameloblastic Origin of Amyloid-Producing Odontogenic Tumors in Cats by Delaney, M. A., Singh, K., Murphy, C. L., Solomon, A., Nel, S., Boy, S. C.

“…Amyloid-producing odontogenic tumors (APOT) are rare, and in cats, the histogenesis of the amyloid remains undetermined. In the present study, APOTs in 3 cats…”
Get full text

CRISPR-Cas9 targeting of MMP13 in human chondrocytes leads to significantly reduced levels of the metalloproteinase and enhanced type II collagen accumulation by Seidl, C.I., Fulga, T.A., Murphy, C.L.

“…To investigate the efficacy of CRISPR-Cas9 mediated editing in human chondrocytes, and to develop a genome editing approach relevant to cell-based repair…”
Get full text

Expression of small breast epithelial mucin (SBEM) protein in tissue microarrays (TMAs) of primary invasive breast cancers by Skliris, G P, Hubé, F, Gheorghiu, I, Mutawe, M M, Penner, C, Watson, P H, Murphy, L C, Leygue, E, Myal, Y

“…Aims:  Small breast epithelial mucin (SBEM) is a recently described gene product that shows promise as a new breast biomarker. The aim was to investigate for…”
Get full text

Altered estrogen receptor α and β messenger RNA expression during human breast tumorigenesis by LEYGUE, E, DOTZLAW, H, WATSON, P. H, MURPHY, L. C

“…Using a multiplex reverse transcription-PCR assay, we compared the relative expression of estrogen receptor (ER) alpha and ER-beta mRNA between adjacent…”
Get full text

Relationship of coregulator and oestrogen receptor isoform expression to de novo tamoxifen resistance in human breast cancer by MURPHY, L. C, LEYGUE, E, NIU, Y, SNELL, L, HO, S.-M, WATSON, P. H

“…This study addresses the hypothesis that altered expression of oestrogen receptor-beta and/or altered relative expression of coactivators and corepressors of…”
Get full text

Inducible upregulation of oestrogen receptor-β1 affects oestrogen and tamoxifen responsiveness in MCF7 human breast cancer cells by Murphy, L C, Peng, B, Lewis, A, Davie, J R, Leygue, E, Kemp, A, Ung, K, Vendetti, M, Shiu, R

“…To investigate the effect of altered oestrogen receptor (ER)α and ERβ expression on oestrogen and anti-oestrogen action in breast cancer, we have stably…”
Get full text

Antibody-Mediated Resolution of Light Chain-Associated Amyloid Deposits by Hrncic, Rudi, Wall, Jonathan, Wolfenbarger, Dennis A., Murphy, Charles L., Schell, Maria, Weiss, Deborah T., Solomon, Alan

“…Primary light-chain-associated (AL) amyloidosis is characterized by the deposition in tissue of monoclonal light chains as fibrils. With rare exception, this…”
Get full text

Systemic AA Amyloidosis in the Common Marmoset by Ludlage, E, Murphy, C. L, Davern, S. M, Solomon, A, Weiss, D. T, Glenn-Smith, D, Dworkin, S, Mansfield, K. G

“…The common marmoset (Callithrix jacchus) is a small New World primate native to Brazil that has been used extensively in biomedical research. A retrospective…”
Get full text

The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-α and MMP13 by Jones, S.W., Ph.D, Watkins, G, Le Good, N, Roberts, S., B.Sc, Murphy, C.L., Ph.D, Brockbank, S.M.V., B.Sc, Needham, M.R.C., B.Sc, Read, S.J., Ph.D, Newham, P., Ph.D

“…Summary Objective To identify differentially expressed microRNAs (miRNAs) in human osteoarthritic (OA) cartilage and bone tissue and to determine their…”
Get full text

The Human Orphan Receptor PXR Messenger RNA Is Expressed in Both Normal and Neoplastic Breast Tissue by DOTZLAW, H, LEYGUE, E, WATSON, P, MURPHY, L. C

“…The expression of PXR mRNA and a variant PXR mRNA, deleted in 111 nucleotides in the ligand-binding domain, was detected by reverse transcription-PCR…”
Get full text

Estrogen receptor-β messenger RNA expression in human breast tumor biopsies : Relationship to steroid receptor status and regulation by progestins by DOTZLAW, H, LEYGUE, E, WATSON, P. H, MURPHY, L. C

“…When the level of estrogen receptor (ER)-beta mRNA in tumors, determined by reverse transcription-PCR, was assessed according to either ER status or PR status…”
Get full text

Psoriasin (S100A7) Expression and Invasive Breast Cancer by Al-Haddad, Sahar, Zhang, Zi, Leygue, Etienne, Snell, Linda, Huang, Aihua, Niu, Yulian, Hiller-Hitchcock, Tamara, Hole, Kate, Murphy, Leigh C., Watson, Peter H.

“…Alteration of psoriasin (S100A7) expression has previously been identified in association with the transition from preinvasive to invasive breast cancer. In…”
Get full text

Clinical significance of estrogen receptor phosphorylation by Murphy, Leigh C, Seekallu, Srinivas V, Watson, Peter H

“…Multiple sites of phosphorylation on human estrogen receptor α (ERα) have been identified by a variety of methodologies. Now with the emerging availability of…”
Get full text

Steroid receptors in human breast tumorigenesis and breast cancer progression by Murphy, L.C, Watson, P

“…Steroid hormones, in particular estrogen and progesterone, play important roles in normal and neoplastic breast development. Alterations in both estrogen…”
Get full text