Search Results - "Murphy, Kathryn L."

Identification of the Critical Residues of Bradykinin Receptor B1 for Interaction with the Kinins Guided by Site-Directed Mutagenesis and Molecular Modeling by Ha, Sookhee N, Hey, Pat J, Ransom, Rick W, Bock, Mark G, Su, Dai-Shi, Murphy, Kathryn L, Chang, Ray, Chen, Tsing-Bau, Pettibone, Douglas, Hess, J. Fred

“…We report the critical residues for the interaction of the kinins with human bradykinin receptor 1 (B1) using site-directed mutagenesis in conjunction with…”
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Binding modes of dihydroquinoxalinones in a homology model of bradykinin receptor 1 by Ha, Sookhee N., Hey, Pat J., Ransom, Rick W., Harrell, C. Meacham, Murphy, Kathryn L., Chang, Ray, Chen, Tsing-Bau, Su, Dai-Shi, Markowitz, M. Kristine, Bock, Mark G., Freidinger, Roger M., Hess, Fred J.

“…We report the first homology model of human bradykinin receptor B1 generated from the crystal structure of bovine rhodopsin as a template. Using an automated…”
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Generation and characterization of a human bradykinin receptor B1 transgenic rat as a pharmacodynamic model by Hess, J Fred, Ransom, Richard W, Zeng, Zhizhen, Chang, Raymond S L, Hey, Patricia J, Warren, Lee, Harrell, Charles M, Murphy, Kathryn L, Chen, Tsing-Bau, Miller, Patricia J, Lis, Edward, Reiss, Duane, Gibson, Raymond E, Markowitz, M Kristine, DiPardo, Robert M, Su, Dai-Shi, Bock, Mark G, Gould, Robert J, Pettibone, Douglas J

“…Antagonists of the B1 bradykinin receptor (B1R) offer the promise of novel therapeutic agents for the treatment of inflammatory and neuropathic pain. However,…”
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Pharmacological characterization and radioligand binding properties of a high-affinity, nonpeptide, bradykinin B1 receptor antagonist by RANSOM, Richard W, HARRELL, Charles M, SU, Dai-Shi, MARKOWITZ, M. Kristine, WALLACE, Michael A, RAAB, Conrad E, JONES, Allen N, DEAN, Dennis C, PETTIBONE, Douglas J, FREIDINGER, Roger M, BOCK, Mark G, REISS, Duane R, MURPHY, Kathryn L, CHANG, Raymond S. L, HESS, J. Fred, MILLER, Patricia J, O'MALLEY, Stacey S, HEY, Pat J, KUNAPULI, Priya

“…Compound A (N-[2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethyl]-2-[(2R)-1-(2-napthylsulfonyl)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl]acetamide) is a member of…”
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Pharmacology of L-744,453, a novel nonpeptidyl endothelin antagonist by Williams, David L, Murphy, Kathryn L, Nolan, Nancy A, O'Brien, Julie A, Lis, Edward V, Pettibone, Douglas J, Clineschmidt, Bradley V, Krause, Stephen M, Veber, Daniel F, Naylor, Elizabeth M, Chakravarty, Prasun K, Walsh, Thomas F, Dhanoa, Dale M, Chent, Anna, Bagley, Scott W, Fitch, Kenneth J, Greenlee, William J

“…L-744,453 ((±)3-[4-(1-carboxy-1-(3,4-methylenedioxyphenyl)methoxy)-3,5-dipropylphenylmethyl]-3H-imidazo[4,5- c]pyridine) is an endothelin (ET) receptor…”
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Pharmacological characterization and radioligand binding properties of a high-affinity, nonpeptide, bradykinin B 1 receptor antagonist by Ransom, Richard W., Harrell, Charles M., Reiss, Duane R., Murphy, Kathryn L., Chang, Raymond S.L., Hess, J. Fred, Miller, Patricia J., O'Malley, Stacey S., Hey, Pat J., Kunapuli, Priya, Su, Dai-Shi, Markowitz, M. Kristine, Wallace, Michael A., Raab, Conrad E., Jones, Allen N., Dean, Dennis C., Pettibone, Douglas J., Freidinger, Roger M., Bock, Mark G.

“…Compound A ( N-{2-[4-(4,5-dihydro-1 H-imidazol-2-yl)phenyl]ethyl}-2-[(2 R)-1-(2-napthylsulfonyl)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl]acetamide) is a member…”
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Potent dual antagonists of endothelin and angiotensin II receptors derived from α-phenoxyphenylacetic acids (Part III) by Walsh, Thomas F., Fitch, Kenneth J., Williams, David L., Murphy, Kathryn L., Nolan, Nancy A., Pettibone, Douglas J., Chang, Raymond S.L., O'Malley, Stacey S., Clineschmidt, Bradley V., Veber, Daniel F., Greenlee, William J.

“…Screening a collection of α-phenoxyphenylacetic acid derived angiotensin II antagonists identified weak actives in an endothelin receptor binding assay…”
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