Search Results - "Murphy, KM"

T lymphocyte differentiation in the periphery by Murphy, Kenneth M

“…The development of immune responses is significantly influenced by emerging patterns of cytokine expression in activated CD4 + T cells. Recent efforts have…”
Get full text

Interleukin 17-producing CD4 + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages by Weaver, Casey T, Harrington, Laurie E, Hatton, Robin D, Mangan, Paul R, Turner, Henrietta, Murphy, Theresa L, Murphy, Kenneth M

“…CD4(+) T cells producing interleukin 17 (IL-17) are associated with autoimmunity, although the precise mechanisms that control their development are undefined…”
Get full text

The lineage decisions of helper T cells by Murphy, Kenneth M, Reiner, Steven L

“…After encountering antigen, helper T (T(H)) cells undergo differentiation to effector cells, which can secrete high levels of interferon-gamma, interleukin-4…”
Get full text

Lineage commitment in the immune system: the T helper lymphocyte grows up by Glimcher, L H, Murphy, K M

“…Cells of the immune system provide particularly fruitful subjects for the study of lineage commitment. Both T and B lymphocytes undergo complicated patterns of…”
Get full text

Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia by Smith, B. Douglas, Levis, Mark, Beran, Miloslav, Giles, Francis, Kantarjian, Hagop, Berg, Karin, Murphy, Kathleen M., Dauses, Tianna, Allebach, Jeffrey, Small, Donald

“…Activating mutations of FMS-like tyrosine kinase 3 (FLT3) are present in approximately 30% of patients with de novo acute myeloid leukemia (AML) and are…”
Get full text

The development of human visual cortex and clinical implications by Siu, Caitlin R, Murphy, Kathryn M

“…The primary visual cortex (V1) is the first cortical area that processes visual information. Normal development of V1 depends on binocular vision during the…”
Get full text

B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator by Murphy, Kenneth M, Sedy, John R, Gavrieli, Maya, Potter, Karen G, Hurchla, Michelle A, Lindsley, R Coleman, Hildner, Kai, Scheu, Stefanie, Pfeffer, Klaus, Ware, Carl F, Murphy, Theresa L

“…B and T lymphocyte attenuator (BTLA) provides an inhibitory signal to B and T cells. Previously, indirect observations suggested that B7x was a ligand for…”
Get full text

T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4 + T cells by Murphy, Kenneth M, Afkarian, Maryam, Sedy, John R, Yang, Jianfei, Jacobson, Nils G, Cereb, Nezih, Yang, Soo Y, Murphy, Theresa L

“…T helper type 1 (T(H)1) cell development involves interferon-gamma (IFN-gamma) signaling through signal transducer and activator of transcription 1 (STAT1) and…”
Get full text

Activation of human CD4 + cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype by Atkinson, John P, Kemper, Claudia, Chan, Andrew C, Green, Jonathan M, Brett, Kelly A, Murphy, Kenneth M

“…The immune system must distinguish not only between self and non-self, but also between innocuous and pathological foreign antigens to prevent unnecessary or…”
Get full text

BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1 by Murphy, Kenneth M, Watanabe, Norihiko, Gavrieli, Maya, Sedy, John R, Yang, Jianfei, Fallarino, Francesca, Loftin, Susan K, Hurchla, Michelle A, Zimmerman, Natalie, Sim, Julia, Zang, Xingxing, Murphy, Theresa L, Russell, John H, Allison, James P

“…During activation, T cells express receptors for receiving positive and negative costimulatory signals. Here we identify the B and T lymphocyte attenuator…”
Get full text

Outcomes of Older People Admitted to Postacute Facilities with Delirium by Marcantonio, Edward R., Kiely, Dan K., Simon, Samuel E., John Orav, E., Jones, Richard N., Murphy, Katharine M., Bergmann, Margaret A.

“…Objectives: To compare outcomes of patients admitted to postacute skilled nursing facilities with delirium, subsyndromal delirium, and no delirium. Design:…”
Get full text

ERM is required for transcriptional control of the spermatogonial stem cell niche by Chen, Chen, Chandrashekar, Varadaraj, Arber, Silvia, Carnes, Kay, Cheng, Alec M, Murphy, Theresa L, Grigura, Vadim, Lim, Hyunjung, Hofmann, Marie-Claude, Ouyang, Wenjun, Zhou, Qing, Hess, Rex A, Murphy, Kenneth M, Zhao, Guang-Quan, Hassell, John A, Kurpios, Natasza

“…Division of spermatogonial stem cells produces daughter cells that either maintain their stem cell identity or undergo differentiation to form mature sperm…”
Get full text

Functional diversity of helper T lymphocytes by Abbas, Abul K, Murphy, Kenneth M, Sher, Alan

“…The existence of subsets of CD4+ helper T lymphocytes that differ in their cytokine secretion patterns and effector functions provides a framework for…”
Get full text

Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: Deleterious BRCA2 mutations in 17 by MURPHY, Kathleen M, BRUNE, Kieran A, GRIFFIN, Constance, SOLLENBERGER, Jennifer E, PETERSEN, Gloria M, BANSAL, Ravi, HRUBAN, Ralph H, KERN, Scott E

“…It is estimated that familial aggregation and genetic susceptibility play a role in as many as 10% of pancreatic ductal adenocarcinomas. To investigate the…”
Get full text

Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells by Szabo, S J, Dighe, A S, Gubler, U, Murphy, K M

“…The developmental commitment to a T helper 1 (Th1)- or Th2-type response can significantly influence host immunity to pathogens. Extinction of the IL-12…”
Get full text

Population size estimation in Yellowstone wolves with error-prone noninvasive microsatellite genotypes by Creel, S, Spong, G, Sands, J.L, Rotella, J, Zeigle, J, Joe, L, Murphy, K.M, Smith, D

“…Determining population sizes can be difficult, but is essential for conservation. By counting distinct microsatellite genotypes, DNA from noninvasive samples…”
Get full text

B and T Lymphocyte Attenuator Exhibits Structural and Expression Polymorphisms and Is Highly Induced in Anergic CD4+ T Cells by Hurchla, Michelle A, Sedy, John R, Gavrielli, Maya, Drake, Charles G, Murphy, Theresa L, Murphy, Kenneth M

“…B and T lymphocyte attenuator (BTLA) was initially identified as expressed on Th1 cells and B cells, but recently reported to be expressed by macrophages,…”
Get full text

The Market for Illegal Goods: The Case of Drugs by Becker, Gary S., Murphy, Kevin M., Grossman, Michael

“…This paper considers the costs of reducing consumption of a good by making its production illegal and punishing apprehended illegal producers. We use illegal…”
Get full text

Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment by Ouyang, W, Löhning, M, Gao, Z, Assenmacher, M, Ranganath, S, Radbruch, A, Murphy, K M

“…The initial source of IL-4-inducing Th2 development and the mechanism of stable Th2 commitment remain obscure. We found the reduced level of IL-4 production in…”
Get full text

Trophic Facilitation by Introduced Top Predators: Grey Wolf Subsidies to Scavengers in Yellowstone National Park by Wilmers, Christopher C., Crabtree, Robert L., Smith, Douglas W., Murphy, Kerry M., Getz, Wayne M.

“…1. The reintroduction of grey wolves Canis lupus (L.) to Yellowstone National Park provides a natural experiment in which to study the effects of a keystone…”
Get full text