Search Results - "Murphy, John R"

Mechanism of diphtheria toxin catalytic domain delivery to the eukaryotic cell cytosol and the cellular factors that directly participate in the process by Murphy, John R

“…Research on diphtheria and anthrax toxins over the past three decades has culminated in a detailed understanding of their structure function relationships…”
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Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis by Parveen, Sadiya, Shen, Jessica, Lun, Shichun, Zhao, Liang, Alt, Jesse, Koleske, Benjamin, Leone, Robert D., Rais, Rana, Powell, Jonathan D., Murphy, John R., Slusher, Barbara S., Bishai, William R.

“…As one of the most successful human pathogens, Mycobacterium tuberculosis ( Mtb ) has evolved a diverse array of determinants to subvert host immunity and…”
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In vivo interferon-gamma induced changes in gene expression dramatically alter neutrophil phenotype by Ambruso, Daniel R, Briones, Natalie J, Baroffio, Angelina F, Murphy, John R, Tran, Alexander D, Gowan, Katherine, Sanford, Bridget, Ellison, Michael, Jones, Kenneth L

“…The cytokine Interferon-γ (IFN-γ) exerts powerful immunoregulatory effects on the adaptive immune system and also enhances functions of the neutrophil (PMN)…”
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Therapeutic targeting with DABIL‐4 depletes myeloid suppressor cells in 4T1 triple‐negative breast cancer model by Parveen, Sadiya, Siddharth, Sumit, Cheung, Laurene S., Kumar, Alok, Shen, Jessica, Murphy, John R., Sharma, Dipali, Bishai, William R.

“…In many solid tumors including triple‐negative breast cancer (TNBC), upregulation of the interleukin‐4 receptor (IL‐4R) has been shown to promote cancer cell…”
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The Cytosolic Entry of Diphtheria Toxin Catalytic Domain Requires a Host Cell Cytosolic Translocation Factor Complex by Ratts, Ryan, Zeng, Huiyan, Berg, Eric A., Blue, Clare, McComb, Mark E., Costello, Cathy E., vanderSpek, Johanna C., Murphy, John R.

“…In vitro delivery of the diphtheria toxin catalytic (C) domain from the lumen of purified early endosomes to the external milieu requires the addition of both…”
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COPI coatomer complex proteins facilitate the translocation of anthrax lethal factor across vesicular membranes in vitro by Tamayo, Alfred G, Bharti, Ajit, Trujillo, Carolina, Harrison, Robert, Murphy, John R

“…The delivery of the diphtheria toxin catalytic domain (DTA) from acidified endosomes into the cytoplasm of eukaryotic cells requires protein-protein…”
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Identification of Immunologic and Pathologic Parameters of Death versus Survival in Respiratory Tularemia by Chiavolini, Damiana, Alroy, Joseph, King, Carol A, Jorth, Peter, Weir, Susan, Madico, Guillermo, Murphy, John R, Wetzler, Lee M

“…Francisella tularensis can cause severe disseminated disease after respiratory infection. The identification of factors involved in mortality or recovery…”
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Neisseria meningitidis PorB, a Toll-Like Receptor 2 Ligand, Improves the Capacity of Francisella tularensis Lipopolysaccharide To Protect Mice against Experimental Tularemia by Chiavolini, Damiana, Weir, Susan, Murphy, John R, Wetzler, Lee M

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Second-generation IL-2 receptor-targeted diphtheria fusion toxin exhibits antitumor activity and synergy with anti–PD-1 in melanoma by Cheung, Laurene S., Fu, Juan, Kumar, Pankaj, Kumar, Amit, Urbanowski, Michael E., Ihms, Elizabeth A., Parveen, Sadiya, Bullen, C. Korin, Patrick, Garrett J., Harrison, Robert, Murphy, John R., Pardoll, Drew M., Bishai, William R.

“…Denileukin diftitox (DAB-IL-2, Ontak) is a diphtheria-toxin–based fusion protein that depletes CD25-positive cells including regulatory T cells and has been…”
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Effective Host-Directed Therapy for Tuberculosis by Depletion of Myeloid-Derived Suppressor Cells and Related Cells Using a Diphtheria Toxin Fusion Protein by Parveen, Sadiya, Lun, Shichun, Urbanowski, Michael E, Cardin, Mitchell, Shen, Jessica, Murphy, John R, Bishai, William R

“…Abstract Myeloid-derived suppressor cells (MDSCs) are present in elevated numbers in tuberculosis patients and have been found to be permissive for…”
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A Conserved Motif in Transmembrane Helix 1 of Diphtheria Toxin Mediates Catalytic Domain Delivery to the Cytosol by Ratts, Ryan, Carolina Trujillo, Bharti, Ajit, Johanna vander Spek, Harrison, Robert, Murphy, John R.

“…A 10-aa motif in transmembrane helix 1 of diphtheria toxin that is conserved in anthrax edema factor, anthrax lethal factor, and botulinum neurotoxin serotypes…”
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Suppressor Cell–Depleting Immunotherapy With Denileukin Diftitox is an Effective Host-Directed Therapy for Tuberculosis by Gupta, Shashank, Cheung, Laurene, Pokkali, Supriya, Winglee, Kathryn, Guo, Haidan, Murphy, John R., Bishai, William R.

“…Host-directed therapies that augment host immune effector mechanisms may serve as important adjunctive therapies for tuberculosis treatment. We evaluated the…”
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The Gonococcal Fur Regulon: Identification of Additional Genes Involved in Major Catabolic, Recombination, and Secretory Pathways by Sebastian, Shite, Agarwal, Sarika, Murphy, John R, Genco, Caroline Attardo

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Recent advances with Treg depleting fusion protein toxins for cancer immunotherapy by Kumar, Pankaj, Kumar, Amit, Parveen, Sadiya, Murphy, John R, Bishai, William

“…T regulatory cells (Tregs) are an important T cell population for immune tolerance, prevention of autoimmune diseases and inhibition of antitumor immunity. The…”
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Corynebacterium diphtheriae : Diphtheria Toxin, the tox Operon, and Its Regulation by Fe2 + Activation of apo-DtxR by Parveen, Sadiya, Bishai, William R, Murphy, John R

“…Diphtheria is one of the most well studied of all the bacterial infectious diseases. These milestone studies of toxigenic along with its primary virulence…”
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Metal Stoichiometry and Functional Studies of the Diphtheria Toxin Repressor by Spiering, Michelle M., Ringe, Dagmar, Murphy, John R., Marletta, Michael A.

“…Diphtheria toxin repressor (DtxR) is a transition metal ion-activated repressor in Corynebacterium diphtheriae. DtxR is an iron sensor; metal-bound DtxR…”
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Both Corynebacterium diphtheriae DtxR(E175K) and Mycobacterium tuberculosis IdeR(D177K) Are Dominant Positive Repressors of IdeR-Regulated Genes in M. tuberculosis by Manabe, Yukari C, Hatem, Christine L, Kesavan, Anup K, Durack, Justin, Murphy, John R

“…The diphtheria toxin repressor (DtxR) is an important iron-dependent transcriptional regulator of known virulence genes in Corynebacterium diphtheriae. The…”
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Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin by Jones, Peter, Storer, R. Ian, Sabnis, Yogesh A, Wakenhut, Florian M, Whitlock, Gavin A, England, Katherine S, Mukaiyama, Takasuke, Dehnhardt, Christoph M, Coe, Jotham W, Kortum, Steve W, Chrencik, Jill E, Brown, David G, Jones, Rhys M, Murphy, John R, Yeoh, Thean, Morgan, Paul, Kilty, Iain

“…By use of a structure-based computational method for identification of structurally novel Janus kinase (JAK) inhibitors predicted to bind beyond the ATP…”
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Attenuation of Virulence in Mycobacterium tuberculosis Expressing a Constitutively Active Iron Repressor by Manabe, Yukari C., Saviola, Beatrice J., Sun, Li, Murphy, John R., Bishai, William R.

“…Iron is an essential nutrient for the survival of most organisms and has played a central role in the virulence of many infectious disease pathogens…”
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Genetic and Biophysical Studies of Diphtheria Toxin Repressor (DtxR) and the Hyperactive Mutant DtxR(E175K) Support a Multistep Model of Activation by Love, John F., vanderSpek, Johanna C., Marin, Vedrana, Guerrero, Luis, Logan, Timothy M., Murphy, John R., Mekalanos, John J.

“…The diphtheria toxin repressor (DtxR) from Corynebacterium diphtheriae is the prototypic member of a superfamily of transition metal ion-activated…”
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